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Reduction of Serum Concentrations and Synergy between Retinol, β-Carotene, and Zinc According to Cancer Staging and Different Treatment Modalities Prior to Radiation Therapy in Women with Breast Cancer.
Nutrients 2019; 11(12)N

Abstract

The procedures used for breast cancer treatment are able to increase the level of oxidative stress and cause depletion of antioxidants.

OBJECTIVES

To investigate the relationship between serum concentrations of retinol, β-carotene, and zinc, according to breast cancer staging, considering different treatment modalities prior to radiation therapy and the synergistic action between these micronutrients.

METHODS

This is a cross-sectional observational study comprising a cohort of patients with breast cancer which was carried out prior to radiation therapy. Patients were divided into 3 groups: G1 comprised women who had undergone breast-conserving surgery, G2 comprised those who had undergone chemotherapy, and G3 those who had undergone breast-conserving surgery and chemotherapy. Serum concentrations of retinol, β-carotene, and zinc were quantified. Breast cancer staging was based on the TNM (Tumor, Node, Metastasis) classification of malignant tumors, a type of staging tool for different cancers.

RESULTS

A total of 230 patients were assessed. A decrease of the serum concentrations of the micronutrients assessed as the staging level of the disease increased was observed. Surgery alone had a greater negative impact on serum concentrations of retinol. Considering the treatments prior to radiotherapy, patients undergoing surgery alone and chemotherapy associated with surgery had higher percentages of deficiency of β-carotene and retinol. There was a positive correlation between the concentrations of zinc, retinol, and β-carotene, showing a synergy between these micronutrients.

CONCLUSION

A significant reduction in the serum concentrations of the assessed micronutrients was observed, according to the increase in breast cancer staging. The synergy between the micronutrients must be considered in order to maximize the benefits and minimize the adverse effects of irradiation to normal cells.

Authors+Show Affiliations

Social Applied Nutrition Department, Micronutrients Research Center (NPqM), Federal University of Rio de Janeiro, Rio de Janeiro 21.941-902, Brazil.Social Applied Nutrition Department, Micronutrients Research Center (NPqM), Federal University of Rio de Janeiro, Rio de Janeiro 21.941-902, Brazil. Department of Radiation Oncology, Ingá Radiotherapy Clinic (CRI), Brazilian Institute of Oncology (IBO), Federal University of Rio de Janeiro, Niterói 24.210-470, Brazil. Department of Radiation Oncology, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro 22.451-900, Brazil. Department of Radiology, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro 21.941-902, Brazil.Department of Radiation Oncology, Ingá Radiotherapy Clinic (CRI), Brazilian Institute of Oncology (IBO), Federal University of Rio de Janeiro, Niterói 24.210-470, Brazil. Department of Radiation Oncology, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro 22.451-900, Brazil.Department of Radiology, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro 21.941-902, Brazil.Department of Radiation Oncology, Ingá Radiotherapy Clinic (CRI), Brazilian Institute of Oncology (IBO), Federal University of Rio de Janeiro, Niterói 24.210-470, Brazil. Department of Radiation Oncology, Pontifical Catholic University of Rio de Janeiro, Rio de Janeiro 22.451-900, Brazil.Social Applied Nutrition Department, Micronutrients Research Center (NPqM), Federal University of Rio de Janeiro, Rio de Janeiro 21.941-902, Brazil.Social Applied Nutrition Department, Micronutrients Research Center (NPqM), Federal University of Rio de Janeiro, Rio de Janeiro 21.941-902, Brazil.Social Applied Nutrition Department, Micronutrients Research Center (NPqM), Federal University of Rio de Janeiro, Rio de Janeiro 21.941-902, Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31817125

Citation

Rosa, Cintia, et al. "Reduction of Serum Concentrations and Synergy Between Retinol, β-Carotene, and Zinc According to Cancer Staging and Different Treatment Modalities Prior to Radiation Therapy in Women With Breast Cancer." Nutrients, vol. 11, no. 12, 2019.
Rosa C, Franca C, Lanes Vieira S, et al. Reduction of Serum Concentrations and Synergy between Retinol, β-Carotene, and Zinc According to Cancer Staging and Different Treatment Modalities Prior to Radiation Therapy in Women with Breast Cancer. Nutrients. 2019;11(12).
Rosa, C., Franca, C., Lanes Vieira, S., Carvalho, A., Penna, A., Nogueira, C., ... Ramalho, A. (2019). Reduction of Serum Concentrations and Synergy between Retinol, β-Carotene, and Zinc According to Cancer Staging and Different Treatment Modalities Prior to Radiation Therapy in Women with Breast Cancer. Nutrients, 11(12), doi:10.3390/nu11122953.
Rosa C, et al. Reduction of Serum Concentrations and Synergy Between Retinol, β-Carotene, and Zinc According to Cancer Staging and Different Treatment Modalities Prior to Radiation Therapy in Women With Breast Cancer. Nutrients. 2019 Dec 4;11(12) PubMed PMID: 31817125.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduction of Serum Concentrations and Synergy between Retinol, β-Carotene, and Zinc According to Cancer Staging and Different Treatment Modalities Prior to Radiation Therapy in Women with Breast Cancer. AU - Rosa,Cintia, AU - Franca,Carlos, AU - Lanes Vieira,Sérgio, AU - Carvalho,Antônio, AU - Penna,Antônio, AU - Nogueira,Carla, AU - Lessa,Suzane, AU - Ramalho,Andrea, Y1 - 2019/12/04/ PY - 2019/07/17/received PY - 2019/09/01/revised PY - 2019/09/15/accepted PY - 2019/12/11/entrez PY - 2019/12/11/pubmed PY - 2019/12/11/medline KW - antioxidants KW - breast cancer KW - chemotherapy KW - conservative surgery KW - radiotherapy KW - toxicity JF - Nutrients JO - Nutrients VL - 11 IS - 12 N2 - : The procedures used for breast cancer treatment are able to increase the level of oxidative stress and cause depletion of antioxidants. OBJECTIVES: To investigate the relationship between serum concentrations of retinol, β-carotene, and zinc, according to breast cancer staging, considering different treatment modalities prior to radiation therapy and the synergistic action between these micronutrients. METHODS: This is a cross-sectional observational study comprising a cohort of patients with breast cancer which was carried out prior to radiation therapy. Patients were divided into 3 groups: G1 comprised women who had undergone breast-conserving surgery, G2 comprised those who had undergone chemotherapy, and G3 those who had undergone breast-conserving surgery and chemotherapy. Serum concentrations of retinol, β-carotene, and zinc were quantified. Breast cancer staging was based on the TNM (Tumor, Node, Metastasis) classification of malignant tumors, a type of staging tool for different cancers. RESULTS: A total of 230 patients were assessed. A decrease of the serum concentrations of the micronutrients assessed as the staging level of the disease increased was observed. Surgery alone had a greater negative impact on serum concentrations of retinol. Considering the treatments prior to radiotherapy, patients undergoing surgery alone and chemotherapy associated with surgery had higher percentages of deficiency of β-carotene and retinol. There was a positive correlation between the concentrations of zinc, retinol, and β-carotene, showing a synergy between these micronutrients. CONCLUSION: A significant reduction in the serum concentrations of the assessed micronutrients was observed, according to the increase in breast cancer staging. The synergy between the micronutrients must be considered in order to maximize the benefits and minimize the adverse effects of irradiation to normal cells. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/31817125/Reduction_of_Serum_Concentrations_and_Synergy_between_Retinol,_β-Carotene,_and_Zinc_According_to_Cancer_Staging_and_Different_Treatment_Modalities_Prior_to_Radiation_Therapy_in_Women_with_Breast_Cancer L2 - http://www.mdpi.com/resolver?pii=nu11122953 DB - PRIME DP - Unbound Medicine ER -