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Comparing Quality of Life in Breast Cancer Patients Who Underwent Mastectomy Versus Breast-Conserving Surgery: A Meta-Analysis.

Abstract

: The purpose of our study was to carry out a meta-analysis of current literature to determine whether total mastectomy and breast-conserving surgery induce different outcomes in quality of life, based on the breast-cancer-specific module of the European Organizaation for Research and Treatment of Cancer core questionnaire (EORTC QLQ-BR23) used postoperatively. A systematic literature search of PubMed and EMBASE was conducted. Observational clinical studies that compared the quality of life in different surgery groups and presented empirical findings were selected. Six studies met the inclusion criteria. Breast-conserving surgery has statistically significant better outcomes than mastectomy in three of the eight outcomes measured in the EORTC QLQ-BR23, namely body image (standard mean difference, SMD = 1.742, 95% CI 0.579-2.905, p = 0.003), future perspective (SMD = 0.606, 95% CI 0.075-1.138, p = 0.025) and systemic therapy side effects (SMD = -0.641, 95% CI 0.101-1.181, p = 0.020). Our study highlighted that breast-conserving surgery was preferred over mastectomy because breast-conserving surgery leads to better outcomes in body image, future perspectives and less systemic side effects.

Authors+Show Affiliations

Institute of Cognitive Neuroscience, Huaibei Normal University, Huaibei 235000, China. Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.Institute for Preventive Medicine and Public Health, Hanoi Medical University, Hanoi 100000, Vietnam. Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, 21205, USA.Department of Psychological Medicine, National University Hospital, Singapore 119228, Singapore.Institute of Cognitive Neuroscience, Huaibei Normal University, Huaibei 235000, China. Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, Singapore 117599, Singapore.Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, Singapore 117599, Singapore. The China-Singapore (Chongqing) Demonstration Initiative on Strategic Connectivity Think, Tank, Chongqing 400043, China.Institute of Cognitive Neuroscience, Huaibei Normal University, Huaibei 235000, China.Institute of Cognitive Neuroscience, Huaibei Normal University, Huaibei 235000, China.Alice Lee School of Nursing, National University of Singapore, Singapore 117597, Singapore.Institute of Cognitive Neuroscience, Huaibei Normal University, Huaibei 235000, China. Institute for Health Innovation and Technology (iHealthtech), National University of Singapore, Singapore 117599, Singapore. Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore. Centre of Excellence in Behavioral Medicine, Nguyen Tat Thanh University (NTTU), Ho Chi Minh City 70000, Vietnam.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31817811

Citation

Ng, Elvin T., et al. "Comparing Quality of Life in Breast Cancer Patients Who Underwent Mastectomy Versus Breast-Conserving Surgery: a Meta-Analysis." International Journal of Environmental Research and Public Health, vol. 16, no. 24, 2019.
Ng ET, Ang RZ, Tran BX, et al. Comparing Quality of Life in Breast Cancer Patients Who Underwent Mastectomy Versus Breast-Conserving Surgery: A Meta-Analysis. Int J Environ Res Public Health. 2019;16(24).
Ng, E. T., Ang, R. Z., Tran, B. X., Ho, C. S., Zhang, Z., Tan, W., ... Ho, R. C. (2019). Comparing Quality of Life in Breast Cancer Patients Who Underwent Mastectomy Versus Breast-Conserving Surgery: A Meta-Analysis. International Journal of Environmental Research and Public Health, 16(24), doi:10.3390/ijerph16244970.
Ng ET, et al. Comparing Quality of Life in Breast Cancer Patients Who Underwent Mastectomy Versus Breast-Conserving Surgery: a Meta-Analysis. Int J Environ Res Public Health. 2019 12 6;16(24) PubMed PMID: 31817811.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparing Quality of Life in Breast Cancer Patients Who Underwent Mastectomy Versus Breast-Conserving Surgery: A Meta-Analysis. AU - Ng,Elvin T, AU - Ang,Russell Z, AU - Tran,Bach X, AU - Ho,Cyrus S, AU - Zhang,Zhisong, AU - Tan,Wanqiu, AU - Bai,Yu, AU - Zhang,Min, AU - Tam,Wilson W, AU - Ho,Roger C, Y1 - 2019/12/06/ PY - 2019/11/15/received PY - 2019/12/01/revised PY - 2019/12/03/accepted PY - 2019/12/11/entrez PY - 2019/12/11/pubmed PY - 2019/12/11/medline KW - breast cancer KW - breast conserving KW - individualised patient profiles KW - mastectomy KW - meta-analysis KW - patient stratification KW - phenotyping KW - quality of life JF - International journal of environmental research and public health JO - Int J Environ Res Public Health VL - 16 IS - 24 N2 - : The purpose of our study was to carry out a meta-analysis of current literature to determine whether total mastectomy and breast-conserving surgery induce different outcomes in quality of life, based on the breast-cancer-specific module of the European Organizaation for Research and Treatment of Cancer core questionnaire (EORTC QLQ-BR23) used postoperatively. A systematic literature search of PubMed and EMBASE was conducted. Observational clinical studies that compared the quality of life in different surgery groups and presented empirical findings were selected. Six studies met the inclusion criteria. Breast-conserving surgery has statistically significant better outcomes than mastectomy in three of the eight outcomes measured in the EORTC QLQ-BR23, namely body image (standard mean difference, SMD = 1.742, 95% CI 0.579-2.905, p = 0.003), future perspective (SMD = 0.606, 95% CI 0.075-1.138, p = 0.025) and systemic therapy side effects (SMD = -0.641, 95% CI 0.101-1.181, p = 0.020). Our study highlighted that breast-conserving surgery was preferred over mastectomy because breast-conserving surgery leads to better outcomes in body image, future perspectives and less systemic side effects. SN - 1660-4601 UR - https://www.unboundmedicine.com/medline/citation/31817811/Comparing_Quality_of_Life_in_Breast_Cancer_Patients_Who_Underwent_Mastectomy_Versus_Breast-Conserving_Surgery:_A_Meta-Analysis L2 - http://www.mdpi.com/resolver?pii=ijerph16244970 DB - PRIME DP - Unbound Medicine ER -