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The effects of heavy metals on human metabolism.
Toxicol Mech Methods. 2020 Mar; 30(3):167-176.TM

Abstract

As technology continues to advance, heavy metals in drinking water have exceeded recommended limits from regulators around the world. The main source of human exposure to heavy metals is from contaminated drinking water. The effects of drinking water contaminated with heavy metals, such as arsenic, lead, nickel, cadmium and mercury, have gradually caught the attention of the relevant departments and personnel. It is well known that occupational exposure to heavy metals occurs as a result of using these metals in a variety of industrial processes in and/or a variety of materials, including color pigments and alloys. A series of adverse effects on human metabolism has resulted from exposure to heavy metal-contaminated drinking water, which has been recorded from around the world. The general mechanism of heavy metal toxicity is through the production of reactive oxygen species, the appearance of oxidative damage, and subsequent adverse effects on health. Therefore, water contaminated with heavy metals causes high morbidity and mortality worldwide. In order to address concern regarding the health effects of different heavy metals, this paper reviews its sources, distribution and effects of heavy metal on human metabolism.HIGHLIGHTSThe accumulation of heavy metals such as lead, arsenic, mercury, cadmium and nickel will destroy the main metabolic process of human body.Redox reactions in biological systems are caused by carcinogenic metal ions such as nickel and arsenic. The free radicals produced by these reactions cause oxidative damage to proteins and DNA.The accumulation of heavy metals eventually produces reactive oxygen species that can cause oxidative stress, which may lead to the production of various diseases.

Authors+Show Affiliations

Department of Environmental and Occupational Health, School of Public Health, China Medical University, Shenyang, China.Department of Environmental and Occupational Health, School of Public Health, China Medical University, Shenyang, China.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31818169

Citation

Fu, Zhushan, and Shuhua Xi. "The Effects of Heavy Metals On Human Metabolism." Toxicology Mechanisms and Methods, vol. 30, no. 3, 2020, pp. 167-176.
Fu Z, Xi S. The effects of heavy metals on human metabolism. Toxicol Mech Methods. 2020;30(3):167-176.
Fu, Z., & Xi, S. (2020). The effects of heavy metals on human metabolism. Toxicology Mechanisms and Methods, 30(3), 167-176. https://doi.org/10.1080/15376516.2019.1701594
Fu Z, Xi S. The Effects of Heavy Metals On Human Metabolism. Toxicol Mech Methods. 2020;30(3):167-176. PubMed PMID: 31818169.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of heavy metals on human metabolism. AU - Fu,Zhushan, AU - Xi,Shuhua, Y1 - 2019/12/17/ PY - 2019/12/11/pubmed PY - 2020/11/18/medline PY - 2019/12/11/entrez KW - Heavy metals KW - arsenic KW - cadmium KW - lead KW - mercury KW - metabolism KW - nickel SP - 167 EP - 176 JF - Toxicology mechanisms and methods JO - Toxicol Mech Methods VL - 30 IS - 3 N2 - As technology continues to advance, heavy metals in drinking water have exceeded recommended limits from regulators around the world. The main source of human exposure to heavy metals is from contaminated drinking water. The effects of drinking water contaminated with heavy metals, such as arsenic, lead, nickel, cadmium and mercury, have gradually caught the attention of the relevant departments and personnel. It is well known that occupational exposure to heavy metals occurs as a result of using these metals in a variety of industrial processes in and/or a variety of materials, including color pigments and alloys. A series of adverse effects on human metabolism has resulted from exposure to heavy metal-contaminated drinking water, which has been recorded from around the world. The general mechanism of heavy metal toxicity is through the production of reactive oxygen species, the appearance of oxidative damage, and subsequent adverse effects on health. Therefore, water contaminated with heavy metals causes high morbidity and mortality worldwide. In order to address concern regarding the health effects of different heavy metals, this paper reviews its sources, distribution and effects of heavy metal on human metabolism.HIGHLIGHTSThe accumulation of heavy metals such as lead, arsenic, mercury, cadmium and nickel will destroy the main metabolic process of human body.Redox reactions in biological systems are caused by carcinogenic metal ions such as nickel and arsenic. The free radicals produced by these reactions cause oxidative damage to proteins and DNA.The accumulation of heavy metals eventually produces reactive oxygen species that can cause oxidative stress, which may lead to the production of various diseases. SN - 1537-6524 UR - https://www.unboundmedicine.com/medline/citation/31818169/The_effects_of_heavy_metals_on_human_metabolism_ L2 - https://www.tandfonline.com/doi/full/10.1080/15376516.2019.1701594 DB - PRIME DP - Unbound Medicine ER -