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Nasopharyngeal pneumococcal carriage in healthy Turkish children after 13-valent conjugated pneumococcal vaccine implementation in the national immunization program.
J Infect Public Health. 2020 Feb; 13(2):266-274.JI

Abstract

BACKGROUND

In Turkey, pneumococcal conjugated vaccine (PCV) was introduced to the national immunization program as PCV7 in 2008, and was replaced with PCV13 in 2011. The aims of this study were to investigate the effects of PCV13 on nasopharyngeal pneumococcal carriage (NPC) by determining the serotype distribution, and to identify risk factors for carriage, in healthy Turkish children.

METHODS

This prospective study was conducted on 500 healthy children aged 0-13 years between April and November 2014. Nasopharyngeal swab samples were taken, and molecular method for capsular serotyping was performed by multiplex PCR.

RESULTS

Of 500 children, 43.4% were unvaccinated with a PCV (7- or 13-valent), 56.6% were vaccinated and The NPC rate was found to be 9.8%. Of 49 positive Streptococcus pneumoniae isolates, 26 (53%) were PCV13 vaccine strains (VSs), and 17 (34.7%) were non-VS. Six isolates (12.2%) were not typeable by the method applied. The most common serotypes detected were serotype 3 (18.3%), serotype 19F (14.2%), serotype 6A/B (8.1%), serotype 11A (8.1%), and serotype 15B (8.1%). The total coverage rate of the PCV13 serotypes was 60.4%.

CONCLUSION

A significant decrease in carriage rate was detected within three years after the introduction of PCV13 in Turkey. However, the nasopharyngeal carriage of PCV13 strains was found to be interestingly high.

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Authors+Show Affiliations

Kanık Yüksek S
Ankara Hematology Oncology Children's Training and Research Hospital, Pediatric Infectious Diseases Department, Ankara, Turkey. Electronic address: salihakanik@gmail.com.
Tezer H
Gazi University Medical Faculty, Pediatric Infectious Diseases Department, Ankara, Turkey. Electronic address: hasantezer@yahoo.com.
Gülhan B
Ankara Hematology Oncology Children's Training and Research Hospital, Pediatric Infectious Diseases Department, Ankara, Turkey. Electronic address: docbelgin@yahoo.com.
Özkaya Parlakay A
Ankara Hematology Oncology Children's Training and Research Hospital, Pediatric Infectious Diseases Department, Ankara, Turkey. Electronic address: aslinur.o@gmail.com.
Güldemir D
National Molecular Microbiology Reference Laboratory, Public Health General Directorate, Ministry of Health, Ankara, Turkey. Electronic address: dilek06@yahoo.com.tr.
Coskun-Ari FF
National Molecular Microbiology Reference Laboratory, Public Health General Directorate, Ministry of Health, Ankara, Turkey. Electronic address: filizari@yahoo.com.
Bedir Demirdağ T
Gazi University Medical Faculty, Pediatric Infectious Diseases Department, Ankara, Turkey. Electronic address: tugbabedir@gmail.com.
Kara Uzun A
Ankara Hematology Oncology Children's Training and Research Hospital, Pediatric Infectious Diseases Department, Ankara, Turkey. Electronic address: aysunkarauzun@gmail.com.
Kızılgün M
Ankara Hematology Oncology Children's Training and Research Hospital, Pediatric Infectious Diseases Department, Ankara, Turkey. Electronic address: muratklg@gmail.com.
Solmaz S
Gazi University Medical Faculty, Medical Microbiology Department, Ankara, Turkey. Electronic address: medicosinem@gmail.com.
Kılıç S
National Molecular Microbiology Reference Laboratory, Public Health General Directorate, Ministry of Health, Ankara, Turkey. Electronic address: selcukkilic@thsk.gov.tr.
Yalınay Çırak M
Gazi University Medical Faculty, Medical Microbiology Department, Ankara, Turkey. Electronic address: meltemyc@gmail.com.
Baran Aksakal FN
Gazi University Medical Faculty, Public Health Department, Ankara, Turkey. Electronic address: nuraksakal@gmail.com.

MeSH

AdolescentCarrier StateChildChild, PreschoolFemaleHumansImmunization ProgramsInfantInfant, NewbornMaleMultiplex Polymerase Chain ReactionNasopharynxPneumococcal InfectionsPneumococcal VaccinesProspective StudiesRisk FactorsSerotypingStreptococcus pneumoniaeTurkeyVaccines, Conjugate

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31818710

Citation

Kanık Yüksek, Saliha, et al. "Nasopharyngeal Pneumococcal Carriage in Healthy Turkish Children After 13-valent Conjugated Pneumococcal Vaccine Implementation in the National Immunization Program." Journal of Infection and Public Health, vol. 13, no. 2, 2020, pp. 266-274.
Kanık Yüksek S, Tezer H, Gülhan B, et al. Nasopharyngeal pneumococcal carriage in healthy Turkish children after 13-valent conjugated pneumococcal vaccine implementation in the national immunization program. J Infect Public Health. 2020;13(2):266-274.
Kanık Yüksek, S., Tezer, H., Gülhan, B., Özkaya Parlakay, A., Güldemir, D., Coskun-Ari, F. F., Bedir Demirdağ, T., Kara Uzun, A., Kızılgün, M., Solmaz, S., Kılıç, S., Yalınay Çırak, M., & Baran Aksakal, F. N. (2020). Nasopharyngeal pneumococcal carriage in healthy Turkish children after 13-valent conjugated pneumococcal vaccine implementation in the national immunization program. Journal of Infection and Public Health, 13(2), 266-274. https://doi.org/10.1016/j.jiph.2019.10.009
Kanık Yüksek S, et al. Nasopharyngeal Pneumococcal Carriage in Healthy Turkish Children After 13-valent Conjugated Pneumococcal Vaccine Implementation in the National Immunization Program. J Infect Public Health. 2020;13(2):266-274. PubMed PMID: 31818710.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nasopharyngeal pneumococcal carriage in healthy Turkish children after 13-valent conjugated pneumococcal vaccine implementation in the national immunization program. AU - Kanık Yüksek,Saliha, AU - Tezer,Hasan, AU - Gülhan,Belgin, AU - Özkaya Parlakay,Aslınur, AU - Güldemir,Dilek, AU - Coskun-Ari,F Filiz, AU - Bedir Demirdağ,Tuğba, AU - Kara Uzun,Aysun, AU - Kızılgün,Murat, AU - Solmaz,Sinem, AU - Kılıç,Selçuk, AU - Yalınay Çırak,Meltem, AU - Baran Aksakal,Fatma Nur, Y1 - 2019/12/06/ PY - 2019/05/19/received PY - 2019/10/17/revised PY - 2019/10/30/accepted PY - 2019/12/11/pubmed PY - 2020/10/2/medline PY - 2019/12/11/entrez KW - Healthy children KW - Nasopharyngeal carriage KW - PCV13 KW - Pneumococcal conjugated vaccine KW - Serotyping SP - 266 EP - 274 JF - Journal of infection and public health JO - J Infect Public Health VL - 13 IS - 2 N2 - BACKGROUND: In Turkey, pneumococcal conjugated vaccine (PCV) was introduced to the national immunization program as PCV7 in 2008, and was replaced with PCV13 in 2011. The aims of this study were to investigate the effects of PCV13 on nasopharyngeal pneumococcal carriage (NPC) by determining the serotype distribution, and to identify risk factors for carriage, in healthy Turkish children. METHODS: This prospective study was conducted on 500 healthy children aged 0-13 years between April and November 2014. Nasopharyngeal swab samples were taken, and molecular method for capsular serotyping was performed by multiplex PCR. RESULTS: Of 500 children, 43.4% were unvaccinated with a PCV (7- or 13-valent), 56.6% were vaccinated and The NPC rate was found to be 9.8%. Of 49 positive Streptococcus pneumoniae isolates, 26 (53%) were PCV13 vaccine strains (VSs), and 17 (34.7%) were non-VS. Six isolates (12.2%) were not typeable by the method applied. The most common serotypes detected were serotype 3 (18.3%), serotype 19F (14.2%), serotype 6A/B (8.1%), serotype 11A (8.1%), and serotype 15B (8.1%). The total coverage rate of the PCV13 serotypes was 60.4%. CONCLUSION: A significant decrease in carriage rate was detected within three years after the introduction of PCV13 in Turkey. However, the nasopharyngeal carriage of PCV13 strains was found to be interestingly high. SN - 1876-035X UR - https://www.unboundmedicine.com/medline/citation/31818710/Nasopharyngeal_pneumococcal_carriage_in_healthy_Turkish_children_after_13_valent_conjugated_pneumococcal_vaccine_implementation_in_the_national_immunization_program_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1876-0341(19)30347-8 DB - PRIME DP - Unbound Medicine ER -
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