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Retrospective Analysis of Antimicrobial Susceptibility Profiles of Nocardia Species from a Tertiary Hospital and Reference Laboratory, 2011 to 2017.
Antimicrob Agents Chemother. 2020 02 21; 64(3)AA

Abstract

Nocardia species are found worldwide and are opportunistic pathogens of both immunocompromised and immunocompetent hosts. Recent updates to the taxonomy of this genus have indicated that there are more than 90 recognized species of Nocardia with 54 species reported to be clinically relevant. In this paper, we report the species distribution, specimen source distribution, and antimicrobial susceptibility profiles of 2,091 clinical isolates recovered for the years 2011 to 2017 using the updated taxonomy. The most commonly isolated species included Nocardia nova complex, Nocardia cyriacigeorgica, and Nocardia farcinica complex, with an additional 25 species or species complexes recovered from clinical specimens. The antimicrobial susceptibility profile was highly variable between the species, but in general, amikacin, linezolid, and trimethoprim-sulfamethoxazole demonstrated good in vitro activity against most species.

Authors+Show Affiliations

Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA Hamdi.ahmed@mayo.edu.Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA.Division of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA.Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA.Division of Clinical Microbiology, Mayo Clinic, Rochester, Minnesota, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31818815

Citation

Hamdi, Ahmed M., et al. "Retrospective Analysis of Antimicrobial Susceptibility Profiles of Nocardia Species From a Tertiary Hospital and Reference Laboratory, 2011 to 2017." Antimicrobial Agents and Chemotherapy, vol. 64, no. 3, 2020.
Hamdi AM, Fida M, Deml SM, et al. Retrospective Analysis of Antimicrobial Susceptibility Profiles of Nocardia Species from a Tertiary Hospital and Reference Laboratory, 2011 to 2017. Antimicrob Agents Chemother. 2020;64(3).
Hamdi, A. M., Fida, M., Deml, S. M., Abu Saleh, O. M., & Wengenack, N. L. (2020). Retrospective Analysis of Antimicrobial Susceptibility Profiles of Nocardia Species from a Tertiary Hospital and Reference Laboratory, 2011 to 2017. Antimicrobial Agents and Chemotherapy, 64(3). https://doi.org/10.1128/AAC.01868-19
Hamdi AM, et al. Retrospective Analysis of Antimicrobial Susceptibility Profiles of Nocardia Species From a Tertiary Hospital and Reference Laboratory, 2011 to 2017. Antimicrob Agents Chemother. 2020 02 21;64(3) PubMed PMID: 31818815.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Retrospective Analysis of Antimicrobial Susceptibility Profiles of Nocardia Species from a Tertiary Hospital and Reference Laboratory, 2011 to 2017. AU - Hamdi,Ahmed M, AU - Fida,Madiha, AU - Deml,Sharon M, AU - Abu Saleh,Omar M, AU - Wengenack,Nancy L, Y1 - 2020/02/21/ PY - 2019/09/13/received PY - 2019/11/30/accepted PY - 2020/08/21/pmc-release PY - 2019/12/11/pubmed PY - 2019/12/11/medline PY - 2019/12/11/entrez KW - Nocardia KW - antimicrobial agents KW - epidemiology JF - Antimicrobial agents and chemotherapy JO - Antimicrob. Agents Chemother. VL - 64 IS - 3 N2 - Nocardia species are found worldwide and are opportunistic pathogens of both immunocompromised and immunocompetent hosts. Recent updates to the taxonomy of this genus have indicated that there are more than 90 recognized species of Nocardia with 54 species reported to be clinically relevant. In this paper, we report the species distribution, specimen source distribution, and antimicrobial susceptibility profiles of 2,091 clinical isolates recovered for the years 2011 to 2017 using the updated taxonomy. The most commonly isolated species included Nocardia nova complex, Nocardia cyriacigeorgica, and Nocardia farcinica complex, with an additional 25 species or species complexes recovered from clinical specimens. The antimicrobial susceptibility profile was highly variable between the species, but in general, amikacin, linezolid, and trimethoprim-sulfamethoxazole demonstrated good in vitro activity against most species. SN - 1098-6596 UR - https://www.unboundmedicine.com/medline/citation/31818815/Retrospective_Analysis_of_Antimicrobial_Susceptibility_Profiles_of_Nocardia_Species_from_a_Tertiary_Hospital_and_Reference_Laboratory_2011_to_2017_ L2 - http://aac.asm.org/cgi/pmidlookup?view=long&pmid=31818815 DB - PRIME DP - Unbound Medicine ER -
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