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Mitochondrial DNA Haplogroups and Frailty in Adults Living with HIV.
AIDS Res Hum Retroviruses. 2020 03; 36(3):214-219.AR

Abstract

Mitochondrial DNA (mtDNA) haplogroup has been associated with disease risk and longevity. Among persons with HIV (PWH), mtDNA haplogroup has been associated with AIDS progression, neuropathy, cognitive impairment, and gait speed decline. We sought to determine whether haplogroup is associated with frailty and its components among older PWH. A cross-sectional analysis was performed of AIDS Clinical Trials Group A5322 (HAILO) participants with available genome-wide genotype and frailty assessments. Multivariable logistic regression models adjusted for age, gender, education, smoking, hepatitis C, and prior use of didanosine/stavudine. Among 634 participants, 81% were male, 49% non-Hispanic white, 31% non-Hispanic black, and 20% Hispanic. Mean age was 51.0 (standard deviation 7.5) years and median nadir CD4 count was 212 (interquartile range 72, 324) cells/μL; 6% were frail, 7% had slow gait, and 21% weak grip. H haplogroup participants were more likely to be frail/prefrail (p = .064), have slow gait (p = .09), or weak grip (p = .017) compared with non-H haplogroup participants (not all comparisons reached statistical significance). In adjusted analyses, PWH with haplogroup H had a greater odds of being frail versus nonfrail [odds ratio (OR) 4.0 (95% confidence interval 1.0-15.4)] and having weak grip [OR 2.1 (1.1, 4.1)], but not slow gait [OR 1.6 (0.5, 5.0)] compared with non-H haplogroup. Among black and Hispanic participants, haplogroup was not significantly associated with frailty, grip, or gait. Among antiretroviral therapy (ART)-treated PWH, mtDNA haplogroup H was independently associated with weak grip and frailty. This association could represent a mechanism of weakness and frailty in the setting of HIV and ART.

Authors+Show Affiliations

Division of Infectious Diseases, Department of Medicine, University of Colorado-Anschutz Medical Campus, Aurora, Colorado.Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee.Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Johns Hopkins University, Baltimore, Maryland.Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Johns Hopkins University, Baltimore, Maryland.Center for Biostatistics in AIDS Research, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee. Internal Medicine, Meharry Medical College, Nashville, Tennessee.Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

Pub Type(s)

Journal Article
Observational Study
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

31822125

Citation

Erlandson, Kristine M., et al. "Mitochondrial DNA Haplogroups and Frailty in Adults Living With HIV." AIDS Research and Human Retroviruses, vol. 36, no. 3, 2020, pp. 214-219.
Erlandson KM, Bradford Y, Samuels DC, et al. Mitochondrial DNA Haplogroups and Frailty in Adults Living with HIV. AIDS Res Hum Retroviruses. 2020;36(3):214-219.
Erlandson, K. M., Bradford, Y., Samuels, D. C., Brown, T. T., Sun, J., Wu, K., Tassiopoulos, K., Ritchie, M. D., Haas, D. W., & Hulgan, T. (2020). Mitochondrial DNA Haplogroups and Frailty in Adults Living with HIV. AIDS Research and Human Retroviruses, 36(3), 214-219. https://doi.org/10.1089/AID.2019.0233
Erlandson KM, et al. Mitochondrial DNA Haplogroups and Frailty in Adults Living With HIV. AIDS Res Hum Retroviruses. 2020;36(3):214-219. PubMed PMID: 31822125.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mitochondrial DNA Haplogroups and Frailty in Adults Living with HIV. AU - Erlandson,Kristine M, AU - Bradford,Yuki, AU - Samuels,David C, AU - Brown,Todd T, AU - Sun,Jing, AU - Wu,Kunling, AU - Tassiopoulos,Katherine, AU - Ritchie,Marylyn D, AU - Haas,David W, AU - Hulgan,Todd, Y1 - 2020/01/14/ PY - 2019/12/12/pubmed PY - 2019/12/12/medline PY - 2019/12/12/entrez KW - HIV KW - aging KW - frailty KW - haplotypes KW - mitochondria KW - sarcopenia SP - 214 EP - 219 JF - AIDS research and human retroviruses JO - AIDS Res Hum Retroviruses VL - 36 IS - 3 N2 - Mitochondrial DNA (mtDNA) haplogroup has been associated with disease risk and longevity. Among persons with HIV (PWH), mtDNA haplogroup has been associated with AIDS progression, neuropathy, cognitive impairment, and gait speed decline. We sought to determine whether haplogroup is associated with frailty and its components among older PWH. A cross-sectional analysis was performed of AIDS Clinical Trials Group A5322 (HAILO) participants with available genome-wide genotype and frailty assessments. Multivariable logistic regression models adjusted for age, gender, education, smoking, hepatitis C, and prior use of didanosine/stavudine. Among 634 participants, 81% were male, 49% non-Hispanic white, 31% non-Hispanic black, and 20% Hispanic. Mean age was 51.0 (standard deviation 7.5) years and median nadir CD4 count was 212 (interquartile range 72, 324) cells/μL; 6% were frail, 7% had slow gait, and 21% weak grip. H haplogroup participants were more likely to be frail/prefrail (p = .064), have slow gait (p = .09), or weak grip (p = .017) compared with non-H haplogroup participants (not all comparisons reached statistical significance). In adjusted analyses, PWH with haplogroup H had a greater odds of being frail versus nonfrail [odds ratio (OR) 4.0 (95% confidence interval 1.0-15.4)] and having weak grip [OR 2.1 (1.1, 4.1)], but not slow gait [OR 1.6 (0.5, 5.0)] compared with non-H haplogroup. Among black and Hispanic participants, haplogroup was not significantly associated with frailty, grip, or gait. Among antiretroviral therapy (ART)-treated PWH, mtDNA haplogroup H was independently associated with weak grip and frailty. This association could represent a mechanism of weakness and frailty in the setting of HIV and ART. SN - 1931-8405 UR - https://www.unboundmedicine.com/medline/citation/31822125/Mitochondrial_DNA_Haplogroups_and_Frailty_in_Adults_Living_with_HIV_ L2 - https://www.liebertpub.com/doi/10.1089/AID.2019.0233?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -