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Serum and urinary levels of brain-derived neurotrophic factor (BDNF) in enuresis.
Arch Esp Urol. 2019 Dec; 72(10):1032-1037.AE

Abstract

OBJECTIVES

Enuresis is one of the most frequently seen psycho-social problems in childhood, which causes anxiety and stress in the child, thus affecting his/her self-respect and quality of life. The aim of the study was to determine the role of bladder function or psychologic factors or both as factors causing enuresis.

METHODS

This study on pediatric patients with primary enuresis included 30 patients with monosymptomatic nocturnal enuresis (MonoNE), 30 patients with polysymptomatic nocturnal enuresis (PolyNE), and 30 healthy controls, making a total of 90 subjects with an age range of 8-18. In all subjects, the levels of serum and urinary Brain-Derived Neurotrophic Factor (BDNF) were measured, in addition to urinary creatinine levels and calculated as BDNF/Cr ng/mg creatinine (BDNF/ Cr).

RESULTS

The serum BDNF results of the PolyNE group (0.949±0.587) were significantly lower than those of the control group (1.158±0.587) (p=0.014). The urinary BDNF results of the PolyNE group (1.107±0.360) were significantly higher than those of both the MonoNE (0.657±0.272) and the control (0.670±0.271) groups (p<0.0001). The BDNF/Cr results of the PolyNE group (1.472±0.714) were significantly higher than those of the MonoNE group (0.956±1.017) and the control group (0.931±0.618) (p=0.044 and p=0.032, respectively).

CONCLUSIONS

In addition to bladder-specific problems, it is possible for anxiety and psychological stress-induced problems to occur in PolyNE. Therefore, in addition to the increasing number of studies on the bladder in enuresis, further studies on the neurogenic and psychogenic aspects of enuresis should be carried out.

Authors+Show Affiliations

Department of Biochemistry. University of Health Sciences. Konya Training and Research Hospital. Konya. Turkey.Department of Pediatric Nephrology. University of Health Sciences. Konya Training and Research Hospital. Konya. Turkey.Department of Child and Adolescent Psychiatry. University of Health Sciences. Konya Training and Research Hospital. Konya. Turkey.Department of Statistics. Selcuk University. Faculty of Science. Konya. Turkey.Department of Pediatric Nephrology. University of Health Sciences. Konya Training and Research Hospital. Konya. Turkey.Department of Urology. University of Health Sciences. Konya Training and Research Hospital. Konya. Turkey.

Pub Type(s)

Journal Article

Language

eng spa

PubMed ID

31823852

Citation

Kurku, Hüseyin, et al. "Serum and Urinary Levels of Brain-derived Neurotrophic Factor (BDNF) in Enuresis." Archivos Espanoles De Urologia, vol. 72, no. 10, 2019, pp. 1032-1037.
Kurku H, Soran M, Yar A, et al. Serum and urinary levels of brain-derived neurotrophic factor (BDNF) in enuresis. Arch Esp Urol. 2019;72(10):1032-1037.
Kurku, H., Soran, M., Yar, A., Akdam, N., Arslan, Ş., & Gönen, M. (2019). Serum and urinary levels of brain-derived neurotrophic factor (BDNF) in enuresis. Archivos Espanoles De Urologia, 72(10), 1032-1037.
Kurku H, et al. Serum and Urinary Levels of Brain-derived Neurotrophic Factor (BDNF) in Enuresis. Arch Esp Urol. 2019;72(10):1032-1037. PubMed PMID: 31823852.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum and urinary levels of brain-derived neurotrophic factor (BDNF) in enuresis. AU - Kurku,Hüseyin, AU - Soran,Mustafa, AU - Yar,Ahmet, AU - Akdam,Neriman, AU - Arslan,Şükrü, AU - Gönen,Murat, PY - 2019/12/12/entrez PY - 2019/12/12/pubmed PY - 2019/12/18/medline KW - BDNF KW - Bladder KW - Enuresis monosintomática KW - Enuresis polisintomática KW - FNDC KW - Monosymptomatic enuresis KW - Neurotrophins KW - Neurotropinas KW - Polysymptomatic enuresis KW - Vejiga SP - 1032 EP - 1037 JF - Archivos espanoles de urologia JO - Arch Esp Urol VL - 72 IS - 10 N2 - OBJECTIVES: Enuresis is one of the most frequently seen psycho-social problems in childhood, which causes anxiety and stress in the child, thus affecting his/her self-respect and quality of life. The aim of the study was to determine the role of bladder function or psychologic factors or both as factors causing enuresis. METHODS: This study on pediatric patients with primary enuresis included 30 patients with monosymptomatic nocturnal enuresis (MonoNE), 30 patients with polysymptomatic nocturnal enuresis (PolyNE), and 30 healthy controls, making a total of 90 subjects with an age range of 8-18. In all subjects, the levels of serum and urinary Brain-Derived Neurotrophic Factor (BDNF) were measured, in addition to urinary creatinine levels and calculated as BDNF/Cr ng/mg creatinine (BDNF/ Cr). RESULTS: The serum BDNF results of the PolyNE group (0.949±0.587) were significantly lower than those of the control group (1.158±0.587) (p=0.014). The urinary BDNF results of the PolyNE group (1.107±0.360) were significantly higher than those of both the MonoNE (0.657±0.272) and the control (0.670±0.271) groups (p<0.0001). The BDNF/Cr results of the PolyNE group (1.472±0.714) were significantly higher than those of the MonoNE group (0.956±1.017) and the control group (0.931±0.618) (p=0.044 and p=0.032, respectively). CONCLUSIONS: In addition to bladder-specific problems, it is possible for anxiety and psychological stress-induced problems to occur in PolyNE. Therefore, in addition to the increasing number of studies on the bladder in enuresis, further studies on the neurogenic and psychogenic aspects of enuresis should be carried out. SN - 0004-0614 UR - https://www.unboundmedicine.com/medline/citation/31823852/Serum_and_urinary_levels_of_brain_derived_neurotrophic_factor__BDNF__in_enuresis_ L2 - http://www.aeurologia.com/article_detail.php?aid=2f3d6e68c3c250beae7c6b54b040d2fdc6f498b1 DB - PRIME DP - Unbound Medicine ER -