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ASSOCIATION OF VITAMIN D WITH MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DEMENTIA IN OLDER MEXICAN ADULTS.
Rev Invest Clin. 2019; 71(6):381-386.RI

Abstract

Background

It has been proposed that Vitamin D helps reduce the accumulation of cerebral β-amyloid-42 by innate immune stimulation and phagocytosis activation. An association between low Vitamin D levels and Alzheimer's dementia (AD) has been established. We determined the association between Vitamin D, mild cognitive impairment (MCI), and AD in older Mexican adults (> 65 years).

Methods

Cross-sectional study conducted at the memory clinic in a tertiary-level hospital in Mexico City. We evaluated subjects with MCI, AD, and normal cognition (NC) with available serum Vitamin D [25(OH)D] levels (past 6 months). Three categories were assigned according to 25(OH)D levels: sufficiency (> 30 ng/mL), insufficiency (21-29 ng/mL), and deficiency (≤ 20 ng/mL). Descriptive statistics, means and standard deviations were used. Logistic regression analyses adjusted by age, sex, and educational level were performed.

Results

We evaluated 208 patients. Mean age was 79 ± 1 year, 65% (n = 136) were female; and mean educational level was 6.7 ± 2.3 years. Thirty-one subjects (14%) had NC; 42% (n = 88) had MCI; and 43% (n = 89) had AD. Prevalence of Vitamin D deficiency was 54%, more frequent in the AD group (64%) followed by the MCI (59%) and NC (13%) (p < 0.001) groups. In the multivariate logistic regression analysis, Vitamin D deficiency was associated with MCI (HR 25.02 [confidence interval 95% 4.48-139]; p < 0.001) and AD (HR 41.7 [5.76-301]; p < 0.001) after adjusting for confounders.

Conclusions

Serum Vitamin D deficiency was associated with MCI and dementia; low levels produced a greater effect over executive functions.

Authors+Show Affiliations

Geriatric Medicine and Neurology Fellowship Program, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico. Department of Geriatrics, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.Geriatric Medicine and Neurology Fellowship Program, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico. Department of Geriatrics, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.Geriatric Medicine and Neurology Fellowship Program, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.Geriatric Medicine and Neurology Fellowship Program, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.Geriatric Medicine and Neurology Fellowship Program, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.Department of Geriatrics, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico. University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Bordeaux, France.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31823966

Citation

Aguilar-Navarro, Sara G., et al. "ASSOCIATION of VITAMIN D WITH MILD COGNITIVE IMPAIRMENT and ALZHEIMER'S DEMENTIA in OLDER MEXICAN ADULTS." Revista De Investigacion Clinica; Organo Del Hospital De Enfermedades De La Nutricion, vol. 71, no. 6, 2019, pp. 381-386.
Aguilar-Navarro SG, Mimenza-Alvarado AJ, Jiménez-Castillo GA, et al. ASSOCIATION OF VITAMIN D WITH MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DEMENTIA IN OLDER MEXICAN ADULTS. Rev Invest Clin. 2019;71(6):381-386.
Aguilar-Navarro, S. G., Mimenza-Alvarado, A. J., Jiménez-Castillo, G. A., Bracho-Vela, L. A., Yeverino-Castro, S. G., & Ávila-Funes, J. A. (2019). ASSOCIATION OF VITAMIN D WITH MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DEMENTIA IN OLDER MEXICAN ADULTS. Revista De Investigacion Clinica; Organo Del Hospital De Enfermedades De La Nutricion, 71(6), 381-386. https://doi.org/10.24875/RIC.19003079
Aguilar-Navarro SG, et al. ASSOCIATION of VITAMIN D WITH MILD COGNITIVE IMPAIRMENT and ALZHEIMER'S DEMENTIA in OLDER MEXICAN ADULTS. Rev Invest Clin. 2019;71(6):381-386. PubMed PMID: 31823966.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - ASSOCIATION OF VITAMIN D WITH MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DEMENTIA IN OLDER MEXICAN ADULTS. AU - Aguilar-Navarro,Sara G, AU - Mimenza-Alvarado,Alberto J, AU - Jiménez-Castillo,Gilberto A, AU - Bracho-Vela,Leonardo A, AU - Yeverino-Castro,Sara G, AU - Ávila-Funes,José A, PY - 2019/12/12/entrez PY - 2019/12/12/pubmed PY - 2020/5/14/medline KW - Dementia KW - Mild cognitive impairment KW - Older adult KW - Vitamin D SP - 381 EP - 386 JF - Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion JO - Rev. Invest. Clin. VL - 71 IS - 6 N2 - Background: It has been proposed that Vitamin D helps reduce the accumulation of cerebral β-amyloid-42 by innate immune stimulation and phagocytosis activation. An association between low Vitamin D levels and Alzheimer's dementia (AD) has been established. We determined the association between Vitamin D, mild cognitive impairment (MCI), and AD in older Mexican adults (> 65 years). Methods: Cross-sectional study conducted at the memory clinic in a tertiary-level hospital in Mexico City. We evaluated subjects with MCI, AD, and normal cognition (NC) with available serum Vitamin D [25(OH)D] levels (past 6 months). Three categories were assigned according to 25(OH)D levels: sufficiency (> 30 ng/mL), insufficiency (21-29 ng/mL), and deficiency (≤ 20 ng/mL). Descriptive statistics, means and standard deviations were used. Logistic regression analyses adjusted by age, sex, and educational level were performed. Results: We evaluated 208 patients. Mean age was 79 ± 1 year, 65% (n = 136) were female; and mean educational level was 6.7 ± 2.3 years. Thirty-one subjects (14%) had NC; 42% (n = 88) had MCI; and 43% (n = 89) had AD. Prevalence of Vitamin D deficiency was 54%, more frequent in the AD group (64%) followed by the MCI (59%) and NC (13%) (p < 0.001) groups. In the multivariate logistic regression analysis, Vitamin D deficiency was associated with MCI (HR 25.02 [confidence interval 95% 4.48-139]; p < 0.001) and AD (HR 41.7 [5.76-301]; p < 0.001) after adjusting for confounders. Conclusions: Serum Vitamin D deficiency was associated with MCI and dementia; low levels produced a greater effect over executive functions. SN - 0034-8376 UR - https://www.unboundmedicine.com/medline/citation/31823966/ASSOCIATION_OF_VITAMIN_D_WITH_MILD_COGNITIVE_IMPAIRMENT_AND_ALZHEIMER'S_DEMENTIA_IN_OLDER_MEXICAN_ADULTS_ L2 - http://clinicalandtranslationalinvestigation.com/frame_esp.php?id=240 DB - PRIME DP - Unbound Medicine ER -