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Epidemiology of Perceived Physical Fatigability in Older Adults: The Long Life Family Study.

Abstract

BACKGROUND

Fatigability is a construct that measures whole-body tiredness anchored to activities of a fixed intensity and duration; little is known about its epidemiology and heritability.

METHODS

Two generations of family members enriched for exceptional longevity and their spouses were enrolled (2006-2009) in the Long Life Family Study (LLFS). At Visit 2 (2014-2017, N=2,355) perceived physical fatigability was measured using the 10-item self-administered Pittsburgh Fatigability Scale (PFS), along with demographic, medical, behavioral, physical and cognitive risk factors.

RESULTS

Residual genetic heritability of fatigability was 0.263 (p=6.6×10-9) after adjustment for age, sex, and field center. PFS physical scores (mean±SD) and higher physical fatigability prevalence (% PFS≥15) were greater with each age strata: 60-69 (N=1009, 11.0±7.6, 28%), 70-79 (N=847, 12.5±8.1, 37%), 80-89 (N=253, 19.3±9.9, 65.2%), and 90-108 (N=266, 28.6±9.8, 89.5%), p<0.0001, adjusted for sex, field center, and family relatedness. Women had a higher prevalence of perceived physical fatigability compared to men, with the largest difference in the 80-89 age strata, 74.8% vs. 53.5%, p<0.0001. Those with greater body mass index, worse physical and cognitive function, and lower physical activity had significantly higher perceived physical fatigability.

CONCLUSIONS

Perceived physical fatigability is highly prevalent in older adults and strongly associated with age. The family design of LLFS allowed us to estimate the genetic heritability of perceived physical fatigability. Identifying risk factors associated with higher perceived physical fatigability can inform the development of targeted interventions for those most at risk, including older women, older adults with depression, and those who are less physically active.

Authors+Show Affiliations

University of Pittsburgh, Graduate School of Public Health. Pittsburgh, PA, USA.University of Pittsburgh, Graduate School of Public Health. Pittsburgh, PA, USA.University of Pittsburgh, Graduate School of Public Health. Pittsburgh, PA, USA.University of Pittsburgh, Graduate School of Public Health. Pittsburgh, PA, USA.University of Pittsburgh, Graduate School of Public Health. Pittsburgh, PA, USA.University of Southern Denmark, Odense, Denmark.University of Pittsburgh, Graduate School of Public Health. Pittsburgh, PA, USA.Washington University School of Medicine in St. Louis, St. Louis, MO, USA.Boston University School of Medicine, Boston, MA, USA.Columbia University Medical Center, New York, NY, USA.University of Pittsburgh, Graduate School of Public Health. Pittsburgh, PA, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31828303

Citation

LaSorda, Kelsea R., et al. "Epidemiology of Perceived Physical Fatigability in Older Adults: the Long Life Family Study." The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 2019.
LaSorda KR, Gmelin T, Kuipers AL, et al. Epidemiology of Perceived Physical Fatigability in Older Adults: The Long Life Family Study. J Gerontol A Biol Sci Med Sci. 2019.
LaSorda, K. R., Gmelin, T., Kuipers, A. L., Boudreau, R. M., Santanasto, A. J., Christensen, K., ... Glynn, N. W. (2019). Epidemiology of Perceived Physical Fatigability in Older Adults: The Long Life Family Study. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, doi:10.1093/gerona/glz288.
LaSorda KR, et al. Epidemiology of Perceived Physical Fatigability in Older Adults: the Long Life Family Study. J Gerontol A Biol Sci Med Sci. 2019 Dec 12; PubMed PMID: 31828303.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epidemiology of Perceived Physical Fatigability in Older Adults: The Long Life Family Study. AU - LaSorda,Kelsea R, AU - Gmelin,Theresa, AU - Kuipers,Allison L, AU - Boudreau,Robert M, AU - Santanasto,Adam J, AU - Christensen,Kaare, AU - Renner,Sharon W, AU - Wojczynski,Mary K, AU - Andersen,Stacy L, AU - Cosentino,Stephanie, AU - Glynn,Nancy W, AU - ,, Y1 - 2019/12/12/ PY - 2019/08/20/received PY - 2019/12/13/entrez PY - 2019/12/13/pubmed PY - 2019/12/13/medline KW - cognitive function KW - fatigue KW - heritability KW - physical function JF - The journals of gerontology. Series A, Biological sciences and medical sciences JO - J. Gerontol. A Biol. Sci. Med. Sci. N2 - BACKGROUND: Fatigability is a construct that measures whole-body tiredness anchored to activities of a fixed intensity and duration; little is known about its epidemiology and heritability. METHODS: Two generations of family members enriched for exceptional longevity and their spouses were enrolled (2006-2009) in the Long Life Family Study (LLFS). At Visit 2 (2014-2017, N=2,355) perceived physical fatigability was measured using the 10-item self-administered Pittsburgh Fatigability Scale (PFS), along with demographic, medical, behavioral, physical and cognitive risk factors. RESULTS: Residual genetic heritability of fatigability was 0.263 (p=6.6×10-9) after adjustment for age, sex, and field center. PFS physical scores (mean±SD) and higher physical fatigability prevalence (% PFS≥15) were greater with each age strata: 60-69 (N=1009, 11.0±7.6, 28%), 70-79 (N=847, 12.5±8.1, 37%), 80-89 (N=253, 19.3±9.9, 65.2%), and 90-108 (N=266, 28.6±9.8, 89.5%), p<0.0001, adjusted for sex, field center, and family relatedness. Women had a higher prevalence of perceived physical fatigability compared to men, with the largest difference in the 80-89 age strata, 74.8% vs. 53.5%, p<0.0001. Those with greater body mass index, worse physical and cognitive function, and lower physical activity had significantly higher perceived physical fatigability. CONCLUSIONS: Perceived physical fatigability is highly prevalent in older adults and strongly associated with age. The family design of LLFS allowed us to estimate the genetic heritability of perceived physical fatigability. Identifying risk factors associated with higher perceived physical fatigability can inform the development of targeted interventions for those most at risk, including older women, older adults with depression, and those who are less physically active. SN - 1758-535X UR - https://www.unboundmedicine.com/medline/citation/31828303/Epidemiology_of_Perceived_Physical_Fatigability_in_Older_Adults:_The_Long_Life_Family_Study L2 - https://academic.oup.com/biomedgerontology/article-lookup/doi/10.1093/gerona/glz288 DB - PRIME DP - Unbound Medicine ER -