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Comparison of different methods for the estimation of aortic pulse wave velocity from 4D flow cardiovascular magnetic resonance.
J Cardiovasc Magn Reson 2019; 21(1):75JC

Abstract

BACKGROUND

Arterial pulse wave velocity (PWV) is associated with increased mortality in aging and disease. Several studies have shown the accuracy of applanation tonometry carotid-femoral PWV (Cf-PWV) and the relevance of evaluating central aorta stiffness using 2D cardiovascular magnetic resonance (CMR) to estimate PWV, and aortic distensibility-derived PWV through the theoretical Bramwell-Hill model (BH-PWV). Our aim was to compare various methods of aortic PWV (aoPWV) estimation from 4D flow CMR, in terms of associations with age, Cf-PWV, BH-PWV and left ventricular (LV) mass-to-volume ratio while evaluating inter-observer reproducibility and robustness to temporal resolution.

METHODS

We studied 47 healthy subjects (49.5 ± 18 years) who underwent Cf-PWV and CMR including aortic 4D flow CMR as well as 2D cine SSFP for BH-PWV and LV mass-to-volume ratio estimation. The aorta was semi-automatically segmented from 4D flow data, and mean velocity waveforms were estimated in 25 planes perpendicular to the aortic centerline. 4D flow CMR aoPWV was calculated: using velocity curves at two locations, namely ascending aorta (AAo) and distal descending aorta (DAo) aorta (S1, 2D-like strategy), or using all velocity curves along the entire aortic centreline (3D-like strategies) with iterative transit time (TT) estimates (S2) or a plane fitting of velocity curves systolic upslope (S3). For S1 and S2, TT was calculated using three approaches: cross-correlation (TTc), wavelets (TTw) and Fourier transforms (TTf). Intra-class correlation coefficients (ICC) and Bland-Altman biases (BA) were used to evaluate inter-observer reproducibility and effect of lower temporal resolution.

RESULTS

4D flow CMR aoPWV estimates were significantly (p < 0.05) correlated to the CMR-independent Cf-PWV, BH-PWV, age and LV mass-to-volume ratio, with the strongest correlations for the 3D-like strategy using wavelets TT (S2-TTw) (R = 0.62, 0.65, 0.77 and 0.52, respectively, all p < 0.001). S2-TTw was also highly reproducible (ICC = 0.99, BA = 0.09 m/s) and robust to lower temporal resolution (ICC = 0.97, BA = 0.15 m/s).

CONCLUSIONS

Reproducible 4D flow CMR aoPWV estimates can be obtained using full 3D aortic coverage. Such 4D flow CMR stiffness measures were significantly associated with Cf-PWV, BH-PWV, age and LV mass-to-volume ratio, with a slight superiority of the 3D strategy using wavelets transit time (S2-TTw).

Authors+Show Affiliations

Sorbonne Université, INSERM, CNRS, Laboratoire d'Imagerie Biomédicale (LIB), 75006, Paris, France. ESME Sudria Research Lab, Paris, France. Institute of Cardiometabolism and Nutrition (ICAN), Paris, France.Hopital Européen Georges Pompidou, Paris, France.CMLA, ENS Cachan, CNRS, Université Paris-Saclay, 94235, Cachan, France.Sorbonne Université, INSERM, CNRS, Laboratoire d'Imagerie Biomédicale (LIB), 75006, Paris, France. Institute of Cardiometabolism and Nutrition (ICAN), Paris, France.Sorbonne Université, INSERM, CNRS, Laboratoire d'Imagerie Biomédicale (LIB), 75006, Paris, France. Institute of Cardiometabolism and Nutrition (ICAN), Paris, France.Sorbonne Université, INSERM, CNRS, Laboratoire d'Imagerie Biomédicale (LIB), 75006, Paris, France. Institute of Cardiometabolism and Nutrition (ICAN), Paris, France.Sorbonne Université, INSERM, CNRS, Laboratoire d'Imagerie Biomédicale (LIB), 75006, Paris, France. Institute of Cardiometabolism and Nutrition (ICAN), Paris, France.Hopital Européen Georges Pompidou, Paris, France.Sorbonne Université, INSERM, CNRS, Laboratoire d'Imagerie Biomédicale (LIB), 75006, Paris, France.Hopital Européen Georges Pompidou, Paris, France.Universidad Favaloro-CONICET, IMeTTyB, Buenos Aires, Argentina.Hopital Européen Georges Pompidou, Paris, France.Sorbonne Université, INSERM, CNRS, Laboratoire d'Imagerie Biomédicale (LIB), 75006, Paris, France. Institute of Cardiometabolism and Nutrition (ICAN), Paris, France.ESME Sudria Research Lab, Paris, France.Sorbonne Université, INSERM, CNRS, Laboratoire d'Imagerie Biomédicale (LIB), 75006, Paris, France. nadjia.kachenoura@inserm.fr. Institute of Cardiometabolism and Nutrition (ICAN), Paris, France. nadjia.kachenoura@inserm.fr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31829235

Citation

Houriez-Gombaud-Saintonge, Sophia, et al. "Comparison of Different Methods for the Estimation of Aortic Pulse Wave Velocity From 4D Flow Cardiovascular Magnetic Resonance." Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance, vol. 21, no. 1, 2019, p. 75.
Houriez-Gombaud-Saintonge S, Mousseaux E, Bargiotas I, et al. Comparison of different methods for the estimation of aortic pulse wave velocity from 4D flow cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2019;21(1):75.
Houriez-Gombaud-Saintonge, S., Mousseaux, E., Bargiotas, I., De Cesare, A., Dietenbeck, T., Bouaou, K., ... Kachenoura, N. (2019). Comparison of different methods for the estimation of aortic pulse wave velocity from 4D flow cardiovascular magnetic resonance. Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance, 21(1), p. 75. doi:10.1186/s12968-019-0584-x.
Houriez-Gombaud-Saintonge S, et al. Comparison of Different Methods for the Estimation of Aortic Pulse Wave Velocity From 4D Flow Cardiovascular Magnetic Resonance. J Cardiovasc Magn Reson. 2019 Dec 12;21(1):75. PubMed PMID: 31829235.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of different methods for the estimation of aortic pulse wave velocity from 4D flow cardiovascular magnetic resonance. AU - Houriez-Gombaud-Saintonge,Sophia, AU - Mousseaux,Elie, AU - Bargiotas,Ioannis, AU - De Cesare,Alain, AU - Dietenbeck,Thomas, AU - Bouaou,Kevin, AU - Redheuil,Alban, AU - Soulat,Gilles, AU - Giron,Alain, AU - Gencer,Umit, AU - Craiem,Damian, AU - Messas,Emmanuel, AU - Bollache,Emilie, AU - Chenoune,Yasmina, AU - Kachenoura,Nadjia, Y1 - 2019/12/12/ PY - 2018/11/12/received PY - 2019/10/22/accepted PY - 2019/12/13/entrez PY - 2019/12/13/pubmed PY - 2019/12/13/medline KW - 4D flow CMR KW - Aging KW - Aortic stiffness KW - Pulse wave velocity SP - 75 EP - 75 JF - Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance JO - J Cardiovasc Magn Reson VL - 21 IS - 1 N2 - BACKGROUND: Arterial pulse wave velocity (PWV) is associated with increased mortality in aging and disease. Several studies have shown the accuracy of applanation tonometry carotid-femoral PWV (Cf-PWV) and the relevance of evaluating central aorta stiffness using 2D cardiovascular magnetic resonance (CMR) to estimate PWV, and aortic distensibility-derived PWV through the theoretical Bramwell-Hill model (BH-PWV). Our aim was to compare various methods of aortic PWV (aoPWV) estimation from 4D flow CMR, in terms of associations with age, Cf-PWV, BH-PWV and left ventricular (LV) mass-to-volume ratio while evaluating inter-observer reproducibility and robustness to temporal resolution. METHODS: We studied 47 healthy subjects (49.5 ± 18 years) who underwent Cf-PWV and CMR including aortic 4D flow CMR as well as 2D cine SSFP for BH-PWV and LV mass-to-volume ratio estimation. The aorta was semi-automatically segmented from 4D flow data, and mean velocity waveforms were estimated in 25 planes perpendicular to the aortic centerline. 4D flow CMR aoPWV was calculated: using velocity curves at two locations, namely ascending aorta (AAo) and distal descending aorta (DAo) aorta (S1, 2D-like strategy), or using all velocity curves along the entire aortic centreline (3D-like strategies) with iterative transit time (TT) estimates (S2) or a plane fitting of velocity curves systolic upslope (S3). For S1 and S2, TT was calculated using three approaches: cross-correlation (TTc), wavelets (TTw) and Fourier transforms (TTf). Intra-class correlation coefficients (ICC) and Bland-Altman biases (BA) were used to evaluate inter-observer reproducibility and effect of lower temporal resolution. RESULTS: 4D flow CMR aoPWV estimates were significantly (p < 0.05) correlated to the CMR-independent Cf-PWV, BH-PWV, age and LV mass-to-volume ratio, with the strongest correlations for the 3D-like strategy using wavelets TT (S2-TTw) (R = 0.62, 0.65, 0.77 and 0.52, respectively, all p < 0.001). S2-TTw was also highly reproducible (ICC = 0.99, BA = 0.09 m/s) and robust to lower temporal resolution (ICC = 0.97, BA = 0.15 m/s). CONCLUSIONS: Reproducible 4D flow CMR aoPWV estimates can be obtained using full 3D aortic coverage. Such 4D flow CMR stiffness measures were significantly associated with Cf-PWV, BH-PWV, age and LV mass-to-volume ratio, with a slight superiority of the 3D strategy using wavelets transit time (S2-TTw). SN - 1532-429X UR - https://www.unboundmedicine.com/medline/citation/31829235/Comparison_of_different_methods_for_the_estimation_of_aortic_pulse_wave_velocity_from_4D_flow_cardiovascular_magnetic_resonance L2 - https://jcmr-online.biomedcentral.com/articles/10.1186/s12968-019-0584-x DB - PRIME DP - Unbound Medicine ER -