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Chiral phosphoric acid-catalyzed asymmetric dearomatization reactions.
Chem Soc Rev. 2020 Jan 02; 49(1):286-300.CS

Abstract

We summarize in this review the recent development of chiral phosphoric acid (CPA)-catalyzed asymmetric dearomatization reactions. A wide array of electron-rich arenes (indoles, phenols, naphthols, benzothiophenes, benzofurans, etc.) and electron-poor arenes (pyridines, quinolines, isoquinolines, etc.) has been proved reactive towards various reaction partners in the presence of a CPA catalyst, enabling asymmetric dearomatization reactions that lead to structurally-diverse polycyclic molecules. The reactions are grouped according to the roles of the arenes in the reactions (as nucleophiles or electrophiles) and the types of reaction partners. This review closes with a personal perspective on the dynamic research area of asymmetric dearomatization reactions by CPAs.

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Authors+Show Affiliations

Xia ZL
State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China. zhengchao@sioc.ac.cn slyou@sioc.ac.cn.
Xu-Xu QF
No affiliation info available
Zheng C
No affiliation info available
You SL
No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31829319

Citation

Xia, Zi-Lei, et al. "Chiral Phosphoric Acid-catalyzed Asymmetric Dearomatization Reactions." Chemical Society Reviews, vol. 49, no. 1, 2020, pp. 286-300.
Xia ZL, Xu-Xu QF, Zheng C, et al. Chiral phosphoric acid-catalyzed asymmetric dearomatization reactions. Chem Soc Rev. 2020;49(1):286-300.
Xia, Z. L., Xu-Xu, Q. F., Zheng, C., & You, S. L. (2020). Chiral phosphoric acid-catalyzed asymmetric dearomatization reactions. Chemical Society Reviews, 49(1), 286-300. https://doi.org/10.1039/c8cs00436f
Xia ZL, et al. Chiral Phosphoric Acid-catalyzed Asymmetric Dearomatization Reactions. Chem Soc Rev. 2020 Jan 2;49(1):286-300. PubMed PMID: 31829319.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chiral phosphoric acid-catalyzed asymmetric dearomatization reactions. AU - Xia,Zi-Lei, AU - Xu-Xu,Qing-Feng, AU - Zheng,Chao, AU - You,Shu-Li, PY - 2019/12/13/pubmed PY - 2019/12/13/medline PY - 2019/12/13/entrez SP - 286 EP - 300 JF - Chemical Society reviews JO - Chem Soc Rev VL - 49 IS - 1 N2 - We summarize in this review the recent development of chiral phosphoric acid (CPA)-catalyzed asymmetric dearomatization reactions. A wide array of electron-rich arenes (indoles, phenols, naphthols, benzothiophenes, benzofurans, etc.) and electron-poor arenes (pyridines, quinolines, isoquinolines, etc.) has been proved reactive towards various reaction partners in the presence of a CPA catalyst, enabling asymmetric dearomatization reactions that lead to structurally-diverse polycyclic molecules. The reactions are grouped according to the roles of the arenes in the reactions (as nucleophiles or electrophiles) and the types of reaction partners. This review closes with a personal perspective on the dynamic research area of asymmetric dearomatization reactions by CPAs. SN - 1460-4744 UR - https://www.unboundmedicine.com/medline/citation/31829319/Chiral_phosphoric_acid_catalyzed_asymmetric_dearomatization_reactions_ DB - PRIME DP - Unbound Medicine ER -