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Endocrine disrupting chemicals: Impact on human health, wildlife and the environment.
Sci Prog 2019; 102(1):3-42SP

Abstract

Endocrine disrupting chemicals are a group of pollutants that can affect the endocrine system and lead to diseases and dysfunctions across the lifespan of organisms. They are omnipresent. They are in the air we breathe, in the food we eat and in the water we drink. They can be found in our everyday lives through personal care products, household cleaning products, furniture and in children's toys. Every year, hundreds of new chemicals are produced and released onto the market without being tested, and they reach our bodies through everyday products. Permanent exposure to those chemicals may intensify or even become the main cause for the development of diseases such as type 2 diabetes, obesity, cardiovascular diseases and certain types of cancer. In recent years, legislation and regulations have been implemented, which aim to control the release of potentially adverse endocrine disrupting chemicals, often invoking the precautionary principle. The objective of this review is to provide an overview of research on environmental aspects of endocrine disrupting chemicals and their effects on human health, based on evidence from animal and human studies. Emphasis is given to three ubiquitous and persistent groups of chemicals, polychlorinated biphenyls, polybrominated diphenyl ethers and organochlorine pesticides, and on two non-persistent, but ubiquitous, bisphenol A and phthalates. Some selected historical cases are also presented and successful cases of regulation and legislation described. These led to a decrease in exposure and consequent minimization of the effects of these compounds. Recommendations from experts on this field, World Health Organization, scientific reports and from the Endocrine Society are included.

Authors+Show Affiliations

CQC, Department of Chemistry, University of Coimbra, Coimbra, Portugal.CQC, Department of Chemistry, University of Coimbra, Coimbra, Portugal.CQC, Department of Chemistry, University of Coimbra, Coimbra, Portugal.CQC, Department of Chemistry, University of Coimbra, Coimbra, Portugal.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31829784

Citation

Encarnação, Telma, et al. "Endocrine Disrupting Chemicals: Impact On Human Health, Wildlife and the Environment." Science Progress, vol. 102, no. 1, 2019, pp. 3-42.
Encarnação T, Pais AA, Campos MG, et al. Endocrine disrupting chemicals: Impact on human health, wildlife and the environment. Sci Prog. 2019;102(1):3-42.
Encarnação, T., Pais, A. A., Campos, M. G., & Burrows, H. D. (2019). Endocrine disrupting chemicals: Impact on human health, wildlife and the environment. Science Progress, 102(1), pp. 3-42. doi:10.1177/0036850419826802.
Encarnação T, et al. Endocrine Disrupting Chemicals: Impact On Human Health, Wildlife and the Environment. Sci Prog. 2019;102(1):3-42. PubMed PMID: 31829784.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endocrine disrupting chemicals: Impact on human health, wildlife and the environment. AU - Encarnação,Telma, AU - Pais,Alberto Acc, AU - Campos,Maria G, AU - Burrows,Hugh D, Y1 - 2019/01/01/ PY - 2019/12/13/entrez PY - 2019/12/13/pubmed PY - 2019/12/13/medline KW - Endocrine disruption KW - children KW - environment KW - human health KW - policy KW - precautionary principle SP - 3 EP - 42 JF - Science progress JO - Sci Prog VL - 102 IS - 1 N2 - Endocrine disrupting chemicals are a group of pollutants that can affect the endocrine system and lead to diseases and dysfunctions across the lifespan of organisms. They are omnipresent. They are in the air we breathe, in the food we eat and in the water we drink. They can be found in our everyday lives through personal care products, household cleaning products, furniture and in children's toys. Every year, hundreds of new chemicals are produced and released onto the market without being tested, and they reach our bodies through everyday products. Permanent exposure to those chemicals may intensify or even become the main cause for the development of diseases such as type 2 diabetes, obesity, cardiovascular diseases and certain types of cancer. In recent years, legislation and regulations have been implemented, which aim to control the release of potentially adverse endocrine disrupting chemicals, often invoking the precautionary principle. The objective of this review is to provide an overview of research on environmental aspects of endocrine disrupting chemicals and their effects on human health, based on evidence from animal and human studies. Emphasis is given to three ubiquitous and persistent groups of chemicals, polychlorinated biphenyls, polybrominated diphenyl ethers and organochlorine pesticides, and on two non-persistent, but ubiquitous, bisphenol A and phthalates. Some selected historical cases are also presented and successful cases of regulation and legislation described. These led to a decrease in exposure and consequent minimization of the effects of these compounds. Recommendations from experts on this field, World Health Organization, scientific reports and from the Endocrine Society are included. SN - 2047-7163 UR - https://www.unboundmedicine.com/medline/citation/31829784/Endocrine_disrupting_chemicals:_Impact_on_human_health,_wildlife_and_the_environment L2 - http://journals.sagepub.com/doi/full/10.1177/0036850419826802?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -