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Aortic elasticity after aortic coarctation relief: comparison of surgical and interventional therapy by cardiovascular magnetic resonance imaging.
BMC Cardiovasc Disord 2019; 19(1):286BC

Abstract

BACKGROUND

Patients after aortic coarctation (CoA) repair show impaired aortic bioelasticity and altered left ventricular (LV) mechanics, predisposing diastolic dysfunction. Our purpose was to assess aortic bioelasticity and LV properties in CoA patients who underwent endovascular stenting or surgery using cardiovascular magnetic resonance (CMR) imaging.

METHODS

Fifty CoA patients (20.5 ± 9.5 years) were examined by 3-Tesla CMR. Eighteen patients had previous stent implantation and 32 had surgical repair. We performed volumetric analysis of both ventricles (LV, RV) and left atrium (LA) to measure biventricular volumes, ejection fractions, left atrial (LA) volumes, and functional parameters (LAEFPassive, LAEFContractile, LAEFReservoir). Aortic distensibility and pulse wave velocity (PWV) were assessed. Native T1 mapping was applied to examine LV tissue properties. In twelve patients post-contrast T1 mapping was performed.

RESULTS

LV, RV and LA parameters did not differ between the surgical and stent group. There was also no significant difference for aortic distensibility, PWV and T1 relaxation times. Aortic root distensibility correlated negatively with age, BMI, BSA and weight (p < 0.001). Native T1 values correlated negatively with age, weight, BSA and BMI (p < 0.001). Lower post-contrast T1 values were associated with lower aortic arch distensibility and higher aortic arch PWV (p < 0.001).

CONCLUSIONS

CoA patients after surgery or stent implantation did not show significant difference of aortic elasticity. Thus, presumably other factors like intrinsic aortic abnormalities might have a greater impact on aortic elasticity than the approach of repair. Interestingly, our data suggest that native T1 values are influenced by demographic characteristics.

Authors+Show Affiliations

Paediatric Heart Centre, University Hospital Giessen & Marburg, Marburg, Germany.Department of Paediatric Cardiology and Congenital Heart Disease, German Heart Centre Munich, München, Germany.Paediatric Heart Centre, University Hospital Giessen & Marburg, Marburg, Germany.Paediatric Heart Centre, University Hospital Giessen & Marburg, Marburg, Germany.Paediatric Heart Centre, University Hospital Giessen & Marburg, Marburg, Germany.Paediatric Heart Centre, University Hospital Giessen & Marburg, Marburg, Germany.Institute for Medical Informatics, Justus-Liebig-University Giessen, Giessen, Germany.Department of Congenital Heart Disease and Paediatric Cardiology, University Hospital Schleswig-Holstein, Arnold-Heller Strasse 3, 24105, Kiel, Germany. inga-voges@t-online.de.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31830907

Citation

Pieper, Theresa, et al. "Aortic Elasticity After Aortic Coarctation Relief: Comparison of Surgical and Interventional Therapy By Cardiovascular Magnetic Resonance Imaging." BMC Cardiovascular Disorders, vol. 19, no. 1, 2019, p. 286.
Pieper T, Latus H, Schranz D, et al. Aortic elasticity after aortic coarctation relief: comparison of surgical and interventional therapy by cardiovascular magnetic resonance imaging. BMC Cardiovasc Disord. 2019;19(1):286.
Pieper, T., Latus, H., Schranz, D., Kreuder, J., Reich, B., Gummel, K., ... Voges, I. (2019). Aortic elasticity after aortic coarctation relief: comparison of surgical and interventional therapy by cardiovascular magnetic resonance imaging. BMC Cardiovascular Disorders, 19(1), p. 286. doi:10.1186/s12872-019-01270-w.
Pieper T, et al. Aortic Elasticity After Aortic Coarctation Relief: Comparison of Surgical and Interventional Therapy By Cardiovascular Magnetic Resonance Imaging. BMC Cardiovasc Disord. 2019 Dec 12;19(1):286. PubMed PMID: 31830907.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aortic elasticity after aortic coarctation relief: comparison of surgical and interventional therapy by cardiovascular magnetic resonance imaging. AU - Pieper,Theresa, AU - Latus,Heiner, AU - Schranz,Dietmar, AU - Kreuder,Joachim, AU - Reich,Bettina, AU - Gummel,Kerstin, AU - Hudel,Helge, AU - Voges,Inga, Y1 - 2019/12/12/ PY - 2019/04/19/received PY - 2019/11/21/accepted PY - 2019/12/14/entrez PY - 2019/12/14/pubmed PY - 2019/12/14/medline KW - Aortic elasticity KW - Cardiovascular magnetic resonance imaging KW - Coarctation of the aorta KW - Endovascular stent implantation KW - T1 mapping SP - 286 EP - 286 JF - BMC cardiovascular disorders JO - BMC Cardiovasc Disord VL - 19 IS - 1 N2 - BACKGROUND: Patients after aortic coarctation (CoA) repair show impaired aortic bioelasticity and altered left ventricular (LV) mechanics, predisposing diastolic dysfunction. Our purpose was to assess aortic bioelasticity and LV properties in CoA patients who underwent endovascular stenting or surgery using cardiovascular magnetic resonance (CMR) imaging. METHODS: Fifty CoA patients (20.5 ± 9.5 years) were examined by 3-Tesla CMR. Eighteen patients had previous stent implantation and 32 had surgical repair. We performed volumetric analysis of both ventricles (LV, RV) and left atrium (LA) to measure biventricular volumes, ejection fractions, left atrial (LA) volumes, and functional parameters (LAEFPassive, LAEFContractile, LAEFReservoir). Aortic distensibility and pulse wave velocity (PWV) were assessed. Native T1 mapping was applied to examine LV tissue properties. In twelve patients post-contrast T1 mapping was performed. RESULTS: LV, RV and LA parameters did not differ between the surgical and stent group. There was also no significant difference for aortic distensibility, PWV and T1 relaxation times. Aortic root distensibility correlated negatively with age, BMI, BSA and weight (p < 0.001). Native T1 values correlated negatively with age, weight, BSA and BMI (p < 0.001). Lower post-contrast T1 values were associated with lower aortic arch distensibility and higher aortic arch PWV (p < 0.001). CONCLUSIONS: CoA patients after surgery or stent implantation did not show significant difference of aortic elasticity. Thus, presumably other factors like intrinsic aortic abnormalities might have a greater impact on aortic elasticity than the approach of repair. Interestingly, our data suggest that native T1 values are influenced by demographic characteristics. SN - 1471-2261 UR - https://www.unboundmedicine.com/medline/citation/31830907/Aortic_elasticity_after_aortic_coarctation_relief:_comparison_of_surgical_and_interventional_therapy_by_cardiovascular_magnetic_resonance_imaging L2 - https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-019-01270-w DB - PRIME DP - Unbound Medicine ER -