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The Role of Vitamin K in Vascular Calcification.
Adv Chronic Kidney Dis. 2019 11; 26(6):437-444.AC

Abstract

Vascular calcification (VC) is common in advanced chronic kidney disease (CKD), contributes to cardiovascular disease (CVD), and associates with increased mortality. Major risk factors for VC in CKD are increasing age, dialysis vintage, and positive net calcium-phosphate balance. To date, no specific therapy that prevents progression or facilitates regression of VC beyond careful attention to calcium and phosphate balance exists. Accumulating evidence demonstrates that CKD patients may incur subclinical vitamin K deficiency. This deficiency may be induced by exhaustion of vitamin K due to its high requirement by vitamin K-dependent proteins to inhibit VC. This review analyzes the pathophysiological mechanisms and clinical consequences of vitamin K deficiency with emphasis on its involvement on vascular calcification in CKD and end-stage renal disease and its relationship to the bone-vascular axis.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Cozzolino M
Renal Division, ASST Santi Paolo e Carlo, Department of Health Sciences, University of Milan, Milan, Italy. Electronic address: mario.cozzolino@unimi.it.
Fusaro M
National Research Council (CNR), Institute of Clinical Physiology (IFC), Pisa, Italy; Department of Medicine, University of Padua, Padua, Italy.
Ciceri P
Renal Research Laboratory, Department of Nephrology, Dialysis and Renal Transplant, Fondazione Ca' Granda IRCCS, Ospedale Maggiore Policlinico, Milan, Italy.
Gasperoni L
Nephrology Dialysis and Renal Transplant Unit, Department of Experimental Diagnostic and Specialty Medicine (DIMES), S. Orsola Hospital, University of Bologna, Bologna, Italy.
Cianciolo G
Nephrology Dialysis and Renal Transplant Unit, Department of Experimental Diagnostic and Specialty Medicine (DIMES), S. Orsola Hospital, University of Bologna, Bologna, Italy.

MeSH

HumansKidney Failure, ChronicUremiaVascular CalcificationVitamin KVitamin K Deficiency

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31831122

Citation

Cozzolino, Mario, et al. "The Role of Vitamin K in Vascular Calcification." Advances in Chronic Kidney Disease, vol. 26, no. 6, 2019, pp. 437-444.
Cozzolino M, Fusaro M, Ciceri P, et al. The Role of Vitamin K in Vascular Calcification. Adv Chronic Kidney Dis. 2019;26(6):437-444.
Cozzolino, M., Fusaro, M., Ciceri, P., Gasperoni, L., & Cianciolo, G. (2019). The Role of Vitamin K in Vascular Calcification. Advances in Chronic Kidney Disease, 26(6), 437-444. https://doi.org/10.1053/j.ackd.2019.10.005
Cozzolino M, et al. The Role of Vitamin K in Vascular Calcification. Adv Chronic Kidney Dis. 2019;26(6):437-444. PubMed PMID: 31831122.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Role of Vitamin K in Vascular Calcification. AU - Cozzolino,Mario, AU - Fusaro,Maria, AU - Ciceri,Paola, AU - Gasperoni,Lorenzo, AU - Cianciolo,Giuseppe, PY - 2019/07/30/received PY - 2019/10/25/revised PY - 2019/10/28/accepted PY - 2019/12/14/entrez PY - 2019/12/14/pubmed PY - 2020/8/5/medline KW - Chronic kidney disease KW - Matrix Gla protein KW - Vascular calcification KW - Vitamin K KW - Warfarin SP - 437 EP - 444 JF - Advances in chronic kidney disease JO - Adv Chronic Kidney Dis VL - 26 IS - 6 N2 - Vascular calcification (VC) is common in advanced chronic kidney disease (CKD), contributes to cardiovascular disease (CVD), and associates with increased mortality. Major risk factors for VC in CKD are increasing age, dialysis vintage, and positive net calcium-phosphate balance. To date, no specific therapy that prevents progression or facilitates regression of VC beyond careful attention to calcium and phosphate balance exists. Accumulating evidence demonstrates that CKD patients may incur subclinical vitamin K deficiency. This deficiency may be induced by exhaustion of vitamin K due to its high requirement by vitamin K-dependent proteins to inhibit VC. This review analyzes the pathophysiological mechanisms and clinical consequences of vitamin K deficiency with emphasis on its involvement on vascular calcification in CKD and end-stage renal disease and its relationship to the bone-vascular axis. SN - 1548-5609 UR - https://www.unboundmedicine.com/medline/citation/31831122/The_Role_of_Vitamin_K_in_Vascular_Calcification_ DB - PRIME DP - Unbound Medicine ER -