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Cardiovascular target organ damage in premenopausal systemic lupus erythematosus patients and in controls: Are there any differences?

Abstract

OBJECTIVE

to analyze the presence of cardiac and vascular preclinical damage in premenopausal women with systemic lupus erythematosus (SLE) and controls, matched for demographic characteristics and for other cardiovascular risk factors.

METHODS

33 women (mean age 32 ± 7 years) with SLE clinically stable (SLEDAI Score 2.5 ± +1.5) and 33 controls, matched (MC) for sex, age, body mass index (BMI), clinic blood pressure (BP) and antihypertensive treatment (if present) underwent: 24-h BP monitoring, echocardiography with tissue Doppler analysis for left ventricular (LV) structure, systolic and diastolic function, echo-tracking carotid ultrasound for intima-media thickness (IMT) and carotid distensibility measurement, and pulse wave velocity measurement for aortic stiffness (PWV).

RESULTS

by definition no difference was observed for age, sex, BMI and clinic BP values; Framingham risk score was low in SLE and MC (1.3 ± 2.7 vs 1.5 ± 2.3%, p = ns). 24-h BP was similar in SLE and in MC. Systolic function parameters, including LV longitudinal systolic function, an early index of LV systolic dysfunction, were reduced in SLE as compared to MC. Carotid IMT and carotid and aortic stiffness parameters were not different in SLE and MC. At multivariate regression analysis, PWV was independently associated with LV mass in controls and with the steroid weekly dose in SLE patients.

CONCLUSIONS

in young patients with SLE and low activity index of the disease, we did not observe significant vascular alterations as compared to controls with similar CV risk. The early LV systolic impairment observed in SLE patients needs confirmation.

Authors+Show Affiliations

Department of Clinical and Experimental Sciences, University of Brescia, Italy; UOC 2° Medicina, ASST Spedali Civili Brescia, Italy.Department of Clinical and Experimental Sciences, University of Brescia, Italy; UOC 2° Medicina, ASST Spedali Civili Brescia, Italy.Department of Clinical and Experimental Sciences, University of Brescia, Italy; Unit of Rheumatology and Clinical immunology ASST Spedali Civili Brescia, Italy.Department of Clinical and Experimental Sciences, University of Brescia, Italy; UOC 2° Medicina, ASST Spedali Civili Brescia, Italy.Department of Clinical and Experimental Sciences, University of Brescia, Italy; UOC 2° Medicina, ASST Spedali Civili Brescia, Italy.Department of Clinical and Experimental Sciences, University of Brescia, Italy; UOC 2° Medicina, ASST Spedali Civili Brescia, Italy.Department of Clinical and Experimental Sciences, University of Brescia, Italy; UOC 2° Medicina, ASST Spedali Civili Brescia, Italy.Department of Clinical and Experimental Sciences, University of Brescia, Italy; Unit of Rheumatology and Clinical immunology ASST Spedali Civili Brescia, Italy.Department of Clinical and Experimental Sciences, University of Brescia, Italy; Unit of Rheumatology and Clinical immunology ASST Spedali Civili Brescia, Italy.Department of Clinical and Experimental Sciences, University of Brescia, Italy; Unit of Rheumatology and Clinical immunology ASST Spedali Civili Brescia, Italy.Department of Clinical and Experimental Sciences, University of Brescia, Italy; UOC 2° Medicina, ASST Spedali Civili Brescia, Italy. Electronic address: marialorenza.muiesan@unibs.it.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31831254

Citation

Salvetti, Massimo, et al. "Cardiovascular Target Organ Damage in Premenopausal Systemic Lupus Erythematosus Patients and in Controls: Are There Any Differences?" European Journal of Internal Medicine, 2019.
Salvetti M, Paini A, Andreoli L, et al. Cardiovascular target organ damage in premenopausal systemic lupus erythematosus patients and in controls: Are there any differences? Eur J Intern Med. 2019.
Salvetti, M., Paini, A., Andreoli, L., Stassaldi, D., Aggiusti, C., Bertacchini, F., ... Muiesan, M. L. (2019). Cardiovascular target organ damage in premenopausal systemic lupus erythematosus patients and in controls: Are there any differences? European Journal of Internal Medicine, doi:10.1016/j.ejim.2019.12.001.
Salvetti M, et al. Cardiovascular Target Organ Damage in Premenopausal Systemic Lupus Erythematosus Patients and in Controls: Are There Any Differences. Eur J Intern Med. 2019 Dec 9; PubMed PMID: 31831254.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cardiovascular target organ damage in premenopausal systemic lupus erythematosus patients and in controls: Are there any differences? AU - Salvetti,Massimo, AU - Paini,Anna, AU - Andreoli,Laura, AU - Stassaldi,Deborah, AU - Aggiusti,Carlo, AU - Bertacchini,Fabio, AU - Rosei,Claudia Agabiti, AU - Piantoni,Silvia, AU - Franceschini,Franco, AU - Tincani,Angela, AU - Muiesan,Maria Lorenza, Y1 - 2019/12/09/ PY - 2019/08/01/received PY - 2019/11/22/revised PY - 2019/12/02/accepted PY - 2019/12/14/entrez PY - 2019/12/14/pubmed PY - 2019/12/14/medline JF - European journal of internal medicine JO - Eur. J. Intern. Med. N2 - OBJECTIVE: to analyze the presence of cardiac and vascular preclinical damage in premenopausal women with systemic lupus erythematosus (SLE) and controls, matched for demographic characteristics and for other cardiovascular risk factors. METHODS: 33 women (mean age 32 ± 7 years) with SLE clinically stable (SLEDAI Score 2.5 ± +1.5) and 33 controls, matched (MC) for sex, age, body mass index (BMI), clinic blood pressure (BP) and antihypertensive treatment (if present) underwent: 24-h BP monitoring, echocardiography with tissue Doppler analysis for left ventricular (LV) structure, systolic and diastolic function, echo-tracking carotid ultrasound for intima-media thickness (IMT) and carotid distensibility measurement, and pulse wave velocity measurement for aortic stiffness (PWV). RESULTS: by definition no difference was observed for age, sex, BMI and clinic BP values; Framingham risk score was low in SLE and MC (1.3 ± 2.7 vs 1.5 ± 2.3%, p = ns). 24-h BP was similar in SLE and in MC. Systolic function parameters, including LV longitudinal systolic function, an early index of LV systolic dysfunction, were reduced in SLE as compared to MC. Carotid IMT and carotid and aortic stiffness parameters were not different in SLE and MC. At multivariate regression analysis, PWV was independently associated with LV mass in controls and with the steroid weekly dose in SLE patients. CONCLUSIONS: in young patients with SLE and low activity index of the disease, we did not observe significant vascular alterations as compared to controls with similar CV risk. The early LV systolic impairment observed in SLE patients needs confirmation. SN - 1879-0828 UR - https://www.unboundmedicine.com/medline/citation/31831254/Cardiovascular_target_organ_damage_in_premenopausal_systemic_lupus_erythematosus_patients_and_in_controls:_Are_there_any_differences L2 - https://linkinghub.elsevier.com/retrieve/pii/S0953-6205(19)30430-3 DB - PRIME DP - Unbound Medicine ER -