Tags

Type your tag names separated by a space and hit enter

Cumulative Burden of Illness in Veterans With Tardive Dyskinesia and Serious Mental Disorders.
J Clin Psychopharmacol. 2020 Jan/Feb; 40(1):38-45.JC

Abstract

PURPOSE/BACKGROUND

To inform cost-benefit decisions for veterans, the risk of tardive dyskinesia (TD) and its impact on comorbidities and outcomes were assessed.

METHODS/PROCEDURES

In a retrospective study, veterans with schizophrenia/schizoaffective, and bipolar and major depressive disorders receiving antipsychotics during the period October 1, 2014, to September 30, 2015, were identified. Tardive dyskinesia was determined by International Classification of Diseases, Ninth Revision, Clinical Modification codes. Correlates of TD were examined using χ or t tests. Odds ratios (ORs) and β parameters with 95% confidence intervals (CIs) for categorical and continuous variables associated with TD were derived from a multivariate logistic and linear regression, respectively.

FINDINGS/RESULTS

Among 7985 veterans, 332 (4.2%) were diagnosed as having possible TD. The odds of having TD were higher for older veterans (OR, 1.04; 95% CI, 1.03-1.05; P < 0.0001) and veterans with schizophrenia/schizoaffective disorder (OR, 1.54; 95% CI, 1.23-1.91; P < 0.0001) or diabetes (OR, 1.64; 95% CI, 1.30-2.06; P < 0.0001). Veterans with TD received more antipsychotic prescriptions (mean ± SD, 18.4 ± 30.3 vs 13.3 ± 26.4; P = 0.003) and days of supply (233.9 ± 95.4 vs 211.4 ± 102.0; P < 0.0001). They were more likely to have received 2 or more antipsychotics (27.1% vs 19.7%, P = 0.0009) and benztropine (OR, 2.25: 95% CI 1.73-2.91; P < 0.0001). Veterans with TD had a higher Charlson Comorbidity Index score (β = 0.32; SE, 0.09; 95% CI, 0.14-0.49; P = 0.0003) and higher odds of any medical hospitalization (OR, 1.45; 95% CI, 1.07-1.95; P = 0.001).

IMPLICATIONS/CONCLUSIONS

The diagnosis of possible TD was associated with older age, schizophrenia/schizoaffective disorder, medical comorbidity, and hospitalization. Tardive dyskinesia may be a marker for patients at risk of adverse health care outcomes and diminished quality of life.

Authors+Show Affiliations

From the Behavioral Health Service, Corporal Michael J. Crescenz VA Medical Center. University of Pennsylvania Perelman School of Medicine.From the Behavioral Health Service, Corporal Michael J. Crescenz VA Medical Center.Center for Health Equity Research and Promotion, Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA.From the Behavioral Health Service, Corporal Michael J. Crescenz VA Medical Center. University of Pennsylvania Perelman School of Medicine.From the Behavioral Health Service, Corporal Michael J. Crescenz VA Medical Center. University of Pennsylvania Perelman School of Medicine.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31834084

Citation

Caroff, Stanley N., et al. "Cumulative Burden of Illness in Veterans With Tardive Dyskinesia and Serious Mental Disorders." Journal of Clinical Psychopharmacology, vol. 40, no. 1, 2020, pp. 38-45.
Caroff SN, Leong SH, Roberts C, et al. Cumulative Burden of Illness in Veterans With Tardive Dyskinesia and Serious Mental Disorders. J Clin Psychopharmacol. 2020;40(1):38-45.
Caroff, S. N., Leong, S. H., Roberts, C., Berkowitz, R. M., & Campbell, E. C. (2020). Cumulative Burden of Illness in Veterans With Tardive Dyskinesia and Serious Mental Disorders. Journal of Clinical Psychopharmacology, 40(1), 38-45. https://doi.org/10.1097/JCP.0000000000001142
Caroff SN, et al. Cumulative Burden of Illness in Veterans With Tardive Dyskinesia and Serious Mental Disorders. J Clin Psychopharmacol. 2020 Jan/Feb;40(1):38-45. PubMed PMID: 31834084.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cumulative Burden of Illness in Veterans With Tardive Dyskinesia and Serious Mental Disorders. AU - Caroff,Stanley N, AU - Leong,Shirley H, AU - Roberts,Christopher, AU - Berkowitz,Rosalind M, AU - Campbell,E Cabrina, PY - 2019/12/14/pubmed PY - 2020/6/2/medline PY - 2019/12/14/entrez SP - 38 EP - 45 JF - Journal of clinical psychopharmacology JO - J Clin Psychopharmacol VL - 40 IS - 1 N2 - PURPOSE/BACKGROUND: To inform cost-benefit decisions for veterans, the risk of tardive dyskinesia (TD) and its impact on comorbidities and outcomes were assessed. METHODS/PROCEDURES: In a retrospective study, veterans with schizophrenia/schizoaffective, and bipolar and major depressive disorders receiving antipsychotics during the period October 1, 2014, to September 30, 2015, were identified. Tardive dyskinesia was determined by International Classification of Diseases, Ninth Revision, Clinical Modification codes. Correlates of TD were examined using χ or t tests. Odds ratios (ORs) and β parameters with 95% confidence intervals (CIs) for categorical and continuous variables associated with TD were derived from a multivariate logistic and linear regression, respectively. FINDINGS/RESULTS: Among 7985 veterans, 332 (4.2%) were diagnosed as having possible TD. The odds of having TD were higher for older veterans (OR, 1.04; 95% CI, 1.03-1.05; P < 0.0001) and veterans with schizophrenia/schizoaffective disorder (OR, 1.54; 95% CI, 1.23-1.91; P < 0.0001) or diabetes (OR, 1.64; 95% CI, 1.30-2.06; P < 0.0001). Veterans with TD received more antipsychotic prescriptions (mean ± SD, 18.4 ± 30.3 vs 13.3 ± 26.4; P = 0.003) and days of supply (233.9 ± 95.4 vs 211.4 ± 102.0; P < 0.0001). They were more likely to have received 2 or more antipsychotics (27.1% vs 19.7%, P = 0.0009) and benztropine (OR, 2.25: 95% CI 1.73-2.91; P < 0.0001). Veterans with TD had a higher Charlson Comorbidity Index score (β = 0.32; SE, 0.09; 95% CI, 0.14-0.49; P = 0.0003) and higher odds of any medical hospitalization (OR, 1.45; 95% CI, 1.07-1.95; P = 0.001). IMPLICATIONS/CONCLUSIONS: The diagnosis of possible TD was associated with older age, schizophrenia/schizoaffective disorder, medical comorbidity, and hospitalization. Tardive dyskinesia may be a marker for patients at risk of adverse health care outcomes and diminished quality of life. SN - 1533-712X UR - https://www.unboundmedicine.com/medline/citation/31834084/Cumulative_Burden_of_Illness_in_Veterans_With_Tardive_Dyskinesia_and_Serious_Mental_Disorders L2 - https://doi.org/10.1097/JCP.0000000000001142 DB - PRIME DP - Unbound Medicine ER -