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Sleep and neurochemical modulation by cannabidiolic acid methyl ester in rats.
Brain Res Bull. 2020 02; 155:166-173.BR

Abstract

Cannabidiolic acid methyl ester (HU-580) is a more stable compound than cannabidiolic acid (CBDA) which has been shown to be effective in reducing nausea, anxiety, depression behaviors in animal models. Here we extend the investigation of this compound to determine its effect on the sleep-wake cycle in male Wistar rats. HU-580 dose-dependently (0.1, 1.0 or 100 μg/Kg, i.p.) prolonged wakefulness (W) and decreased slow wave sleep (SWS) duration whereas rapid eye movement sleep (REMS) showed no statistical change. In addition, the brain microdialysis probes either placed at nucleus accumbens (NAc) or into the basal forebrain in freely moving animals were used to evaluate the effects of HU-580 treatment on neurotransmitters related to the sleep-wake cycle modulation. HU-580 enhanced extracellular levels of dopamine, serotonin collected from NAc while adenosine and acetylcholine were increased in basal forebrain. In summary, HU-580 seems to possess wake-promoting pharmacological properties and enhances the levels of wake-related neurochemicals. This is the first report of effects of HU-580 on sleep modulation expanding the very limited existent data on the neurobiological effects of HU-580 on rats.

Authors+Show Affiliations

Laboratorio de Neurociencias Moleculares e Integrativas Escuela de Medicina, División Ciencias de la Salud Universidad Anáhuac Mayab Mérida, Yucatán, Mexico; Intercontinental Neuroscience Research Group, Mexico. Electronic address: eric.murillo@anahuac.mx.Centro De Investigaciones Regionales "Dr. Hideyo Noguchi" Universidad Autónoma de Yucatán. Mérida, Yucatán, Mexico.School of Medicine School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.Department of Psychology and Neuroscience Graduate Program University of Guelph, Guelph, Ontario, Canada.Institute for Drug Research, Medical Faculty Hebrew University, Jerusalem, Israel.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31838151

Citation

Murillo-Rodríguez, Eric, et al. "Sleep and Neurochemical Modulation By Cannabidiolic Acid Methyl Ester in Rats." Brain Research Bulletin, vol. 155, 2020, pp. 166-173.
Murillo-Rodríguez E, Arankowsky-Sandoval G, Pertwee RG, et al. Sleep and neurochemical modulation by cannabidiolic acid methyl ester in rats. Brain Res Bull. 2020;155:166-173.
Murillo-Rodríguez, E., Arankowsky-Sandoval, G., Pertwee, R. G., Parker, L., & Mechoulam, R. (2020). Sleep and neurochemical modulation by cannabidiolic acid methyl ester in rats. Brain Research Bulletin, 155, 166-173. https://doi.org/10.1016/j.brainresbull.2019.12.006
Murillo-Rodríguez E, et al. Sleep and Neurochemical Modulation By Cannabidiolic Acid Methyl Ester in Rats. Brain Res Bull. 2020;155:166-173. PubMed PMID: 31838151.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sleep and neurochemical modulation by cannabidiolic acid methyl ester in rats. AU - Murillo-Rodríguez,Eric, AU - Arankowsky-Sandoval,Gloria, AU - Pertwee,Roger G, AU - Parker,Linda, AU - Mechoulam,Raphael, Y1 - 2019/12/12/ PY - 2019/08/12/received PY - 2019/11/25/revised PY - 2019/12/10/accepted PY - 2019/12/16/pubmed PY - 2021/6/4/medline PY - 2019/12/16/entrez KW - Adenosine KW - Cannabinoids KW - Dopamine KW - Sleep KW - Wakefulness SP - 166 EP - 173 JF - Brain research bulletin JO - Brain Res Bull VL - 155 N2 - Cannabidiolic acid methyl ester (HU-580) is a more stable compound than cannabidiolic acid (CBDA) which has been shown to be effective in reducing nausea, anxiety, depression behaviors in animal models. Here we extend the investigation of this compound to determine its effect on the sleep-wake cycle in male Wistar rats. HU-580 dose-dependently (0.1, 1.0 or 100 μg/Kg, i.p.) prolonged wakefulness (W) and decreased slow wave sleep (SWS) duration whereas rapid eye movement sleep (REMS) showed no statistical change. In addition, the brain microdialysis probes either placed at nucleus accumbens (NAc) or into the basal forebrain in freely moving animals were used to evaluate the effects of HU-580 treatment on neurotransmitters related to the sleep-wake cycle modulation. HU-580 enhanced extracellular levels of dopamine, serotonin collected from NAc while adenosine and acetylcholine were increased in basal forebrain. In summary, HU-580 seems to possess wake-promoting pharmacological properties and enhances the levels of wake-related neurochemicals. This is the first report of effects of HU-580 on sleep modulation expanding the very limited existent data on the neurobiological effects of HU-580 on rats. SN - 1873-2747 UR - https://www.unboundmedicine.com/medline/citation/31838151/Sleep_and_neurochemical_modulation_by_cannabidiolic_acid_methyl_ester_in_rats_ DB - PRIME DP - Unbound Medicine ER -