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RNA: interactions drive functionalities.
Mol Biol Rep 2020; 47(2):1413-1434MB

Abstract

RNA is produced from the majority of human genomic sequences, although only a relatively small portion of these transcripts has known functions. Diverse RNA species interact with RNA, DNA, proteins, lipids, and metabolites to form intricate molecular networks. In this review, we attempt to delineate diverse RNA functions by interaction types between RNA and other macromolecules. Through such interactions RNAs participate in essentially every major molecular function and process, including information flow and storage, environment sensing, signal transduction, and gene regulation at transcriptional and posttranscriptional levels. Through such interactions, RNAs promote or inhibit diverse biological processes, and act as catalyzer or quencher to modulate the pace of these progresses. Alterations and personal variations of these interactions are mechanistically coupled with disease etiology and phenotypical variations for clinical use.

Authors+Show Affiliations

Wuxi School of Medicine, Jiangnan University, Wuxi, China. xiaofeng.dai@jiangnan.edu.cn.School of Biotechnology, Jiangnan University, Wuxi, China.Department of Bioengineering, University of California San Diego, San Diego, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31838657

Citation

Dai, Xiaofeng, et al. "RNA: Interactions Drive Functionalities." Molecular Biology Reports, vol. 47, no. 2, 2020, pp. 1413-1434.
Dai X, Zhang S, Zaleta-Rivera K. RNA: interactions drive functionalities. Mol Biol Rep. 2020;47(2):1413-1434.
Dai, X., Zhang, S., & Zaleta-Rivera, K. (2020). RNA: interactions drive functionalities. Molecular Biology Reports, 47(2), pp. 1413-1434. doi:10.1007/s11033-019-05230-7.
Dai X, Zhang S, Zaleta-Rivera K. RNA: Interactions Drive Functionalities. Mol Biol Rep. 2020;47(2):1413-1434. PubMed PMID: 31838657.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - RNA: interactions drive functionalities. AU - Dai,Xiaofeng, AU - Zhang,Shuo, AU - Zaleta-Rivera,Kathia, Y1 - 2019/12/14/ PY - 2019/08/07/received PY - 2019/12/07/accepted PY - 2019/12/16/pubmed PY - 2019/12/16/medline PY - 2019/12/16/entrez KW - Functionalities KW - Non-coding RNA KW - RNA interaction SP - 1413 EP - 1434 JF - Molecular biology reports JO - Mol. Biol. Rep. VL - 47 IS - 2 N2 - RNA is produced from the majority of human genomic sequences, although only a relatively small portion of these transcripts has known functions. Diverse RNA species interact with RNA, DNA, proteins, lipids, and metabolites to form intricate molecular networks. In this review, we attempt to delineate diverse RNA functions by interaction types between RNA and other macromolecules. Through such interactions RNAs participate in essentially every major molecular function and process, including information flow and storage, environment sensing, signal transduction, and gene regulation at transcriptional and posttranscriptional levels. Through such interactions, RNAs promote or inhibit diverse biological processes, and act as catalyzer or quencher to modulate the pace of these progresses. Alterations and personal variations of these interactions are mechanistically coupled with disease etiology and phenotypical variations for clinical use. SN - 1573-4978 UR - https://www.unboundmedicine.com/medline/citation/31838657/RNA:_interactions_drive_functionalities L2 - https://doi.org/10.1007/s11033-019-05230-7 DB - PRIME DP - Unbound Medicine ER -