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Covariation between spontaneous neural activity in the insula and affective temperaments is related to sleep disturbance in individuals with major depressive disorder.
Psychol Med. 2021 04; 51(5):731-740.PM

Abstract

BACKGROUND

Affective temperaments have been considered antecedents of major depressive disorder (MDD). However, little is known about how the covariation between alterations in brain activity and distinct affective temperaments work collaboratively to contribute to MDD. Here, we focus on the insular cortex, a critical hub for the integration of subjective feelings, emotions, and motivations, to examine the neural correlates of affective temperaments and their relationship to depressive symptom dimensions.

METHODS

Twenty-nine medication-free patients with MDD and 58 healthy controls underwent magnetic resonance imaging scanning and completed the Temperament Evaluation of Memphis, Pisa, Paris and San Diego (TEMPS). Patients also received assessments of the Hamilton Depression Rating Scale (HDRS). We used multivariate analyses of partial least squares regression and partial correlation analyses to explore the associations among the insular activity, affective temperaments, and depressive symptom dimensions.

RESULTS

A profile (linear combination) of increased fractional amplitude of low-frequency fluctuations (fALFF) of the anterior insular subregions (left dorsal agranular-dysgranular insula and right ventral agranuar insula) was positively associated with an affective-temperament (depressive, irritable, anxious, and less hyperthymic) profile. The covariation between the insula-fALFF profile and the affective-temperament profile was significantly correlated with the sleep disturbance dimension (especially the middle and late insomnia scores) in the medication-free MDD patients.

CONCLUSIONS

The resting-state spontaneous activity of the anterior insula and affective temperaments collaboratively contribute to sleep disturbances in medication-free MDD patients. The approach used in this study provides a practical way to explore the relationship of multivariate measures in investigating the etiology of mental disorders.

Authors+Show Affiliations

The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou510370, China.The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou510370, China.The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou510370, China.The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou510370, China.The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou510370, China.School of Mental Health, Jining Medical University, Jining272067, China.The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou510370, China.The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou510370, China.School of Nursing, Peking University Health Science Center, Beijing100191, China.

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31839025

Citation

Wu, Huawang, et al. "Covariation Between Spontaneous Neural Activity in the Insula and Affective Temperaments Is Related to Sleep Disturbance in Individuals With Major Depressive Disorder." Psychological Medicine, vol. 51, no. 5, 2021, pp. 731-740.
Wu H, Zheng Y, Zhan Q, et al. Covariation between spontaneous neural activity in the insula and affective temperaments is related to sleep disturbance in individuals with major depressive disorder. Psychol Med. 2021;51(5):731-740.
Wu, H., Zheng, Y., Zhan, Q., Dong, J., Peng, H., Zhai, J., Zhao, J., She, S., & Wu, C. (2021). Covariation between spontaneous neural activity in the insula and affective temperaments is related to sleep disturbance in individuals with major depressive disorder. Psychological Medicine, 51(5), 731-740. https://doi.org/10.1017/S0033291719003647
Wu H, et al. Covariation Between Spontaneous Neural Activity in the Insula and Affective Temperaments Is Related to Sleep Disturbance in Individuals With Major Depressive Disorder. Psychol Med. 2021;51(5):731-740. PubMed PMID: 31839025.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Covariation between spontaneous neural activity in the insula and affective temperaments is related to sleep disturbance in individuals with major depressive disorder. AU - Wu,Huawang, AU - Zheng,Yingjun, AU - Zhan,Qianqian, AU - Dong,Jie, AU - Peng,Hongjun, AU - Zhai,Jinguo, AU - Zhao,Jingping, AU - She,Shenglin, AU - Wu,Chao, Y1 - 2019/12/16/ PY - 2019/12/17/pubmed PY - 2019/12/17/medline PY - 2019/12/17/entrez KW - Affective temperaments KW - fractional amplitude of low-frequency fluctuations KW - insula KW - major depressive disorder KW - partial least squares SP - 731 EP - 740 JF - Psychological medicine JO - Psychol Med VL - 51 IS - 5 N2 - BACKGROUND: Affective temperaments have been considered antecedents of major depressive disorder (MDD). However, little is known about how the covariation between alterations in brain activity and distinct affective temperaments work collaboratively to contribute to MDD. Here, we focus on the insular cortex, a critical hub for the integration of subjective feelings, emotions, and motivations, to examine the neural correlates of affective temperaments and their relationship to depressive symptom dimensions. METHODS: Twenty-nine medication-free patients with MDD and 58 healthy controls underwent magnetic resonance imaging scanning and completed the Temperament Evaluation of Memphis, Pisa, Paris and San Diego (TEMPS). Patients also received assessments of the Hamilton Depression Rating Scale (HDRS). We used multivariate analyses of partial least squares regression and partial correlation analyses to explore the associations among the insular activity, affective temperaments, and depressive symptom dimensions. RESULTS: A profile (linear combination) of increased fractional amplitude of low-frequency fluctuations (fALFF) of the anterior insular subregions (left dorsal agranular-dysgranular insula and right ventral agranuar insula) was positively associated with an affective-temperament (depressive, irritable, anxious, and less hyperthymic) profile. The covariation between the insula-fALFF profile and the affective-temperament profile was significantly correlated with the sleep disturbance dimension (especially the middle and late insomnia scores) in the medication-free MDD patients. CONCLUSIONS: The resting-state spontaneous activity of the anterior insula and affective temperaments collaboratively contribute to sleep disturbances in medication-free MDD patients. The approach used in this study provides a practical way to explore the relationship of multivariate measures in investigating the etiology of mental disorders. SN - 1469-8978 UR - https://www.unboundmedicine.com/medline/citation/31839025/Covariation_between_spontaneous_neural_activity_in_the_insula_and_affective_temperaments_is_related_to_sleep_disturbance_in_individuals_with_major_depressive_disorder_ L2 - https://www.cambridge.org/core/product/identifier/S0033291719003647/type/journal_article DB - PRIME DP - Unbound Medicine ER -