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Glucagon-like peptide-1 receptors in the kidney: impact on renal autoregulation.
Am J Physiol Renal Physiol. 2020 02 01; 318(2):F443-F454.AJ

Abstract

Glucagon-like peptide-1 (GLP-1) and strategies based on this blood sugar-reducing and appetite-suppressing hormone are used to treat obesity and type 2 diabetes. However, the GLP-1 receptor (GLP-1R) is also present in the kidney, where it influences renal function. The effect of GLP-1 on the kidney varies between humans and rodents. The effect of GLP-1 on kidney function also seems to vary depending on its concentration and the physiological or pathological state of the kidney. In studies with rodents or humans, acute infusion of pharmacological doses of GLP-1 stimulates natriuresis and diuresis. However, the effect on the renal vasculature is less clear. In rodents, GLP-1 infusion increases renal plasma flow and glomerular filtration rate, suggesting renal vasodilation. In humans, only a subset of the study participants exhibits increased renal plasma flow and glomerular filtration rate. Differential status of kidney function and changes in renal vascular resistance of the preglomerular arterioles may account for the different responses of the human study participants. Because renal function in patients with type 2 diabetes is already at risk or compromised, understanding the effects of GLP-1R activation on kidney function in these patients is particularly important. This review examines the distribution of GLP-1R in the kidney and the effects elicited by GLP-1 or GLP-1R agonists. By integrating results from acute and chronic studies in healthy individuals and patients with type 2 diabetes along with those from rodent studies, we provide insight into how GLP-1R activation affects renal function and autoregulation.

Authors+Show Affiliations

Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31841385

Citation

Hviid, Aleksander Vauvert R., and Charlotte M. Sørensen. "Glucagon-like Peptide-1 Receptors in the Kidney: Impact On Renal Autoregulation." American Journal of Physiology. Renal Physiology, vol. 318, no. 2, 2020, pp. F443-F454.
Hviid AVR, Sørensen CM. Glucagon-like peptide-1 receptors in the kidney: impact on renal autoregulation. Am J Physiol Renal Physiol. 2020;318(2):F443-F454.
Hviid, A. V. R., & Sørensen, C. M. (2020). Glucagon-like peptide-1 receptors in the kidney: impact on renal autoregulation. American Journal of Physiology. Renal Physiology, 318(2), F443-F454. https://doi.org/10.1152/ajprenal.00280.2019
Hviid AVR, Sørensen CM. Glucagon-like Peptide-1 Receptors in the Kidney: Impact On Renal Autoregulation. Am J Physiol Renal Physiol. 2020 02 1;318(2):F443-F454. PubMed PMID: 31841385.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glucagon-like peptide-1 receptors in the kidney: impact on renal autoregulation. AU - Hviid,Aleksander Vauvert R, AU - Sørensen,Charlotte M, Y1 - 2019/12/16/ PY - 2019/12/17/pubmed PY - 2020/5/12/medline PY - 2019/12/17/entrez KW - diabetes KW - glomerular filtration rate KW - glucagon-like peptide-1 KW - natriuresis KW - vasodilation SP - F443 EP - F454 JF - American journal of physiology. Renal physiology JO - Am. J. Physiol. Renal Physiol. VL - 318 IS - 2 N2 - Glucagon-like peptide-1 (GLP-1) and strategies based on this blood sugar-reducing and appetite-suppressing hormone are used to treat obesity and type 2 diabetes. However, the GLP-1 receptor (GLP-1R) is also present in the kidney, where it influences renal function. The effect of GLP-1 on the kidney varies between humans and rodents. The effect of GLP-1 on kidney function also seems to vary depending on its concentration and the physiological or pathological state of the kidney. In studies with rodents or humans, acute infusion of pharmacological doses of GLP-1 stimulates natriuresis and diuresis. However, the effect on the renal vasculature is less clear. In rodents, GLP-1 infusion increases renal plasma flow and glomerular filtration rate, suggesting renal vasodilation. In humans, only a subset of the study participants exhibits increased renal plasma flow and glomerular filtration rate. Differential status of kidney function and changes in renal vascular resistance of the preglomerular arterioles may account for the different responses of the human study participants. Because renal function in patients with type 2 diabetes is already at risk or compromised, understanding the effects of GLP-1R activation on kidney function in these patients is particularly important. This review examines the distribution of GLP-1R in the kidney and the effects elicited by GLP-1 or GLP-1R agonists. By integrating results from acute and chronic studies in healthy individuals and patients with type 2 diabetes along with those from rodent studies, we provide insight into how GLP-1R activation affects renal function and autoregulation. SN - 1522-1466 UR - https://www.unboundmedicine.com/medline/citation/31841385/Glucagon_like_peptide_1_receptors_in_the_kidney:_impact_on_renal_autoregulation_ L2 - http://journals.physiology.org/doi/full/10.1152/ajprenal.00280.2019?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -