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Recapitulating developmental mechanisms for retinal regeneration.
Prog Retin Eye Res. 2020 05; 76:100824.PR

Abstract

Degeneration of specific retinal neurons in diseases like glaucoma, age-related macular degeneration, and retinitis pigmentosa is the leading cause of irreversible blindness. Currently, there is no therapy to modify the disease-associated degenerative changes. With the advancement in our knowledge about the mechanisms that regulate the development of the vertebrate retina, the approach to treat blinding diseases through regenerative medicine appears a near possibility. Recapitulation of developmental mechanisms is critical for reproducibly generating cells in either 2D or 3D culture of pluripotent stem cells for retinal repair and disease modeling. It is the key for unlocking the neurogenic potential of Müller glia in the adult retina for therapeutic regeneration. Here, we examine the current status and potential of the regenerative medicine approach for the retina in the backdrop of developmental mechanisms.

Authors+Show Affiliations

Department of Ophthalmology and Visual Science, University of Nebraska Medical Center, Omaha, NE, 68198, USA. Electronic address: iahmad@unmc.edu.Department of Ophthalmology and Visual Science, University of Nebraska Medical Center, Omaha, NE, 68198, USA.Department of Ophthalmology and Visual Science, University of Nebraska Medical Center, Omaha, NE, 68198, USA.Center for Translational Neurodegeneration and Regenerative Therapy, Shanghai Tenth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai, 200072, China.

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

31843569

Citation

Ahmad, Iqbal, et al. "Recapitulating Developmental Mechanisms for Retinal Regeneration." Progress in Retinal and Eye Research, vol. 76, 2020, p. 100824.
Ahmad I, Teotia P, Erickson H, et al. Recapitulating developmental mechanisms for retinal regeneration. Prog Retin Eye Res. 2020;76:100824.
Ahmad, I., Teotia, P., Erickson, H., & Xia, X. (2020). Recapitulating developmental mechanisms for retinal regeneration. Progress in Retinal and Eye Research, 76, 100824. https://doi.org/10.1016/j.preteyeres.2019.100824
Ahmad I, et al. Recapitulating Developmental Mechanisms for Retinal Regeneration. Prog Retin Eye Res. 2020;76:100824. PubMed PMID: 31843569.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Recapitulating developmental mechanisms for retinal regeneration. AU - Ahmad,Iqbal, AU - Teotia,Pooja, AU - Erickson,Helen, AU - Xia,Xiaohuan, Y1 - 2019/12/14/ PY - 2019/09/16/received PY - 2019/12/06/revised PY - 2019/12/11/accepted PY - 2019/12/18/pubmed PY - 2019/12/18/medline PY - 2019/12/18/entrez KW - Development KW - Disease modeling KW - Organoid KW - Pluripotent stem cells KW - Regeneration KW - Retina SP - 100824 EP - 100824 JF - Progress in retinal and eye research JO - Prog Retin Eye Res VL - 76 N2 - Degeneration of specific retinal neurons in diseases like glaucoma, age-related macular degeneration, and retinitis pigmentosa is the leading cause of irreversible blindness. Currently, there is no therapy to modify the disease-associated degenerative changes. With the advancement in our knowledge about the mechanisms that regulate the development of the vertebrate retina, the approach to treat blinding diseases through regenerative medicine appears a near possibility. Recapitulation of developmental mechanisms is critical for reproducibly generating cells in either 2D or 3D culture of pluripotent stem cells for retinal repair and disease modeling. It is the key for unlocking the neurogenic potential of Müller glia in the adult retina for therapeutic regeneration. Here, we examine the current status and potential of the regenerative medicine approach for the retina in the backdrop of developmental mechanisms. SN - 1873-1635 UR - https://www.unboundmedicine.com/medline/citation/31843569/Recapitulating_developmental_mechanisms_for_retinal_regeneration L2 - https://linkinghub.elsevier.com/retrieve/pii/S1350-9462(19)30111-9 DB - PRIME DP - Unbound Medicine ER -
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