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Effect of food thickener and jelly wafer on the pharmacokinetics of levofloxacin orally disintegrating tablets.
Heliyon. 2019 Nov; 5(11):e02764.H

Abstract

This study was designed to determine the effects of a food thickener and deglutition aid jelly for oral administration, jelly wafer, on the pharmacokinetics of levofloxacin orally disintegrating tablets. With an increase in immersion time, the disintegration time of levofloxacin orally disintegrating tablets immersed in food thickener was prolonged, whereas that of the tablets immersed in jelly wafer was shortened. The dissolution behavior of non-immersed levofloxacin orally disintegrating tablets was not similar to that of tablets immersed in food thickener, but was similar to that of tablets immersed in jelly wafer. The time to reach the maximum systemic levofloxacin concentration was the same for non-immersed orally disintegrating tablets and tablets immersed in food thickener and jelly wafer. Moreover, there was no significant difference in the maximum concentration after administration between non-immersed orally disintegrating tablets and tablets immersed in food thickener or jelly wafer. These findings suggest that drugs with a high bioavailability, such as levofloxacin, enter the systemic circulation even when administered with a food thickener or jelly wafer.

Authors+Show Affiliations

Department of Clinical Pharmaceutics and Pharmacy Practice, School of Pharmacy, Iwate Medical University, 2-1-1, Nishitokuta, Yahabacho, Shiwagun, Iwate, 028-3694, Japan. Department of Pharmacy, Hospital Bando, 411 Kutsukake, Bando, Ibaraki, 306-0515, Japan.TOWA Pharmaceutical Co., Ltd., Kyoto Analytical Science Center, Kyoto Research Park KISTIC #202, 134, Chudoji Minami-machi, Shimogyo-ku, Kyoto, Kyoto, 600-8813, Japan.TOWA Pharmaceutical Co., Ltd., Kyoto Analytical Science Center, Kyoto Research Park KISTIC #202, 134, Chudoji Minami-machi, Shimogyo-ku, Kyoto, Kyoto, 600-8813, Japan.Department of Pharmacy, Hospital Bando, 411 Kutsukake, Bando, Ibaraki, 306-0515, Japan.Faculty of Pharmacy, Iwaki Meisei University, 5-5-1 Chuodai Iino, Iwaki, Fukushima, 970-8551, Japan.The Nisshin OilliO Group, Ltd., Central Research Laboratory, 1 Shinmori-cho, Isogo-ku, Yokohama 235-8558, Japan.Department of Internal Medicine, Hospital Bando, 411 Kutsukake, Bando, Ibaraki, 306-0515 Japan.TOWA Pharmaceutical Co., Ltd., Kyoto Analytical Science Center, Kyoto Research Park KISTIC #202, 134, Chudoji Minami-machi, Shimogyo-ku, Kyoto, Kyoto, 600-8813, Japan.Department of Pharmacy, Hospital Bando, 411 Kutsukake, Bando, Ibaraki, 306-0515, Japan. Faculty of Health Sciences, Tsukuba International University, 6-20-1 Manabe, Tsuchiura, Ibaraki, 300-0051, Japan.Department of Clinical Pharmaceutics and Pharmacy Practice, School of Pharmacy, Iwate Medical University, 2-1-1, Nishitokuta, Yahabacho, Shiwagun, Iwate, 028-3694, Japan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31844704

Citation

Tomita, Takashi, et al. "Effect of Food Thickener and Jelly Wafer On the Pharmacokinetics of Levofloxacin Orally Disintegrating Tablets." Heliyon, vol. 5, no. 11, 2019, pp. e02764.
Tomita T, Yamaguchi A, Nishimura N, et al. Effect of food thickener and jelly wafer on the pharmacokinetics of levofloxacin orally disintegrating tablets. Heliyon. 2019;5(11):e02764.
Tomita, T., Yamaguchi, A., Nishimura, N., Goto, H., Sumiya, K., Arakawa, R., Yoshida, T., Tachiki, H., Kohda, Y., & Kudo, K. (2019). Effect of food thickener and jelly wafer on the pharmacokinetics of levofloxacin orally disintegrating tablets. Heliyon, 5(11), e02764. https://doi.org/10.1016/j.heliyon.2019.e02764
Tomita T, et al. Effect of Food Thickener and Jelly Wafer On the Pharmacokinetics of Levofloxacin Orally Disintegrating Tablets. Heliyon. 2019;5(11):e02764. PubMed PMID: 31844704.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of food thickener and jelly wafer on the pharmacokinetics of levofloxacin orally disintegrating tablets. AU - Tomita,Takashi, AU - Yamaguchi,Akiko, AU - Nishimura,Naoe, AU - Goto,Hidekazu, AU - Sumiya,Kenji, AU - Arakawa,Ryo, AU - Yoshida,Tadashi, AU - Tachiki,Hidehisa, AU - Kohda,Yukinao, AU - Kudo,Kenzo, Y1 - 2019/11/26/ PY - 2018/10/15/received PY - 2019/04/07/revised PY - 2019/10/30/accepted PY - 2019/12/18/entrez PY - 2019/12/18/pubmed PY - 2019/12/18/medline KW - Food technology KW - Food thickener KW - Jelly-wafer KW - Levofloxacin KW - Orally-disintegrating tablet KW - Pharmaceutical chemistry KW - Pharmacokinetics SP - e02764 EP - e02764 JF - Heliyon JO - Heliyon VL - 5 IS - 11 N2 - This study was designed to determine the effects of a food thickener and deglutition aid jelly for oral administration, jelly wafer, on the pharmacokinetics of levofloxacin orally disintegrating tablets. With an increase in immersion time, the disintegration time of levofloxacin orally disintegrating tablets immersed in food thickener was prolonged, whereas that of the tablets immersed in jelly wafer was shortened. The dissolution behavior of non-immersed levofloxacin orally disintegrating tablets was not similar to that of tablets immersed in food thickener, but was similar to that of tablets immersed in jelly wafer. The time to reach the maximum systemic levofloxacin concentration was the same for non-immersed orally disintegrating tablets and tablets immersed in food thickener and jelly wafer. Moreover, there was no significant difference in the maximum concentration after administration between non-immersed orally disintegrating tablets and tablets immersed in food thickener or jelly wafer. These findings suggest that drugs with a high bioavailability, such as levofloxacin, enter the systemic circulation even when administered with a food thickener or jelly wafer. SN - 2405-8440 UR - https://www.unboundmedicine.com/medline/citation/31844704/Effect_of_food_thickener_and_jelly_wafer_on_the_pharmacokinetics_of_levofloxacin_orally_disintegrating_tablets L2 - https://linkinghub.elsevier.com/retrieve/pii/S2405-8440(19)36424-2 DB - PRIME DP - Unbound Medicine ER -
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