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Effects of alternate-day fasting on body weight and dyslipidaemia in patients with non-alcoholic fatty liver disease: a randomised controlled trial.
BMC Gastroenterol. 2019 Dec 18; 19(1):219.BG

Abstract

BACKGROUND

Alternate-day fasting (ADF) is a novel diet therapy that may achieve reduction in body weight and improvement of dyslipidaemia, but the impact of this diet on patients with non-alcoholic fatty liver disease (NAFLD) remains unknown. The aim of this study was to evaluate the effects of ADF on the body weight and lipid profile of individuals with NAFLD.

METHODS

NAFLD patients (n = 271) were randomised to the ADF group, time-restricted feeding (TRF) group, or the control group and subjected to the respective diet for 12 weeks. Anthropometric measurements (body weight, fat mass/fat-free mass) were performed, and plasma lipids were analysed enzymatically.

RESULTS

Within 4 weeks, the body weight decreased significantly (P < 0.001) in the ADF group by 4.56 ± 0.41 kg (6.1 ± 0.5%) and the TRF group by 3.62 ± 0.65 kg (4.83 ± 0.9%) compared to the control group, and it decreased even more after 12 weeks in both groups (ADF: - 4.04 ± 0.54 kg, 5.4 ± 0.7%; TRF: - 3.25 ± 0.67 kg, 4.3 ± 0.9%). Fat mass was significantly reduced by ADF (- 3.49 ± 0.37 kg; 11 ± 1.2%) and TRF (- 2.91 ± 0.41 kg; 9.6 ± 1.3%), with ADF leading to a further reduction in fat mass after 12 weeks (- 3.48 ± 0.38 kg; 11 ± 1.2%). Total cholesterol was significantly decreased at both time points in the ADF group (- 0.91 ± 0.07 mmol/L; 18.5 ± 1.5%) compared to the control and TRF groups. Both ADF (- 0.64 ± 0.06 mmol/L; 25 ± 1.9%) and TRF (0.58 ± 0.07 mmol/L; 20 ± 1.7%) achieved a significant reduction in serum triglycerides (P < 0.001) after 12 weeks. Changes in fat free mass, HDL, LDL, fasting insulin, glucose, liver stiffness, and systolic or diastolic blood pressure did not differ between the groups.

CONCLUSIONS

ADF appears to be an effective diet therapy for individuals with NAFLD that can achieve weight loss and improvement of dyslipidaemia within a relatively short period of time (4 to 12 weeks). Potential preventive effects of ADF on cardiovascular disease need to be confirmed by future investigations.

TRIAL REGISTRATION

ChiCTR1900024411, this trial was retrospectively registered on July 10, 2019.

Authors+Show Affiliations

Department of Gastroenterology, Hunan Provincial People' Hospital, The First Affiliated Hospital of Human Normal University, Jiefang Road West, Changsha, 410005, Hunan, China.Department of Gastroenterology, Hunan Provincial People' Hospital, The First Affiliated Hospital of Human Normal University, Jiefang Road West, Changsha, 410005, Hunan, China.Department of Gastroenterology, Hunan Provincial People' Hospital, The First Affiliated Hospital of Human Normal University, Jiefang Road West, Changsha, 410005, Hunan, China.Department of Gastroenterology, Hunan Provincial People' Hospital, The First Affiliated Hospital of Human Normal University, Jiefang Road West, Changsha, 410005, Hunan, China.Department of Gastroenterology, Hunan Provincial People' Hospital, The First Affiliated Hospital of Human Normal University, Jiefang Road West, Changsha, 410005, Hunan, China.Department of Gastroenterology, Hunan Provincial People' Hospital, The First Affiliated Hospital of Human Normal University, Jiefang Road West, Changsha, 410005, Hunan, China.Department of Gastroenterology, Hunan Provincial People' Hospital, The First Affiliated Hospital of Human Normal University, Jiefang Road West, Changsha, 410005, Hunan, China.Department of Gastroenterology, Hunan Provincial People' Hospital, The First Affiliated Hospital of Human Normal University, Jiefang Road West, Changsha, 410005, Hunan, China. chenzhiyuan@hunnu.edu.cn.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

31852444

Citation

Cai, Hua, et al. "Effects of Alternate-day Fasting On Body Weight and Dyslipidaemia in Patients With Non-alcoholic Fatty Liver Disease: a Randomised Controlled Trial." BMC Gastroenterology, vol. 19, no. 1, 2019, p. 219.
Cai H, Qin YL, Shi ZY, et al. Effects of alternate-day fasting on body weight and dyslipidaemia in patients with non-alcoholic fatty liver disease: a randomised controlled trial. BMC Gastroenterol. 2019;19(1):219.
Cai, H., Qin, Y. L., Shi, Z. Y., Chen, J. H., Zeng, M. J., Zhou, W., Chen, R. Q., & Chen, Z. Y. (2019). Effects of alternate-day fasting on body weight and dyslipidaemia in patients with non-alcoholic fatty liver disease: a randomised controlled trial. BMC Gastroenterology, 19(1), 219. https://doi.org/10.1186/s12876-019-1132-8
Cai H, et al. Effects of Alternate-day Fasting On Body Weight and Dyslipidaemia in Patients With Non-alcoholic Fatty Liver Disease: a Randomised Controlled Trial. BMC Gastroenterol. 2019 Dec 18;19(1):219. PubMed PMID: 31852444.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of alternate-day fasting on body weight and dyslipidaemia in patients with non-alcoholic fatty liver disease: a randomised controlled trial. AU - Cai,Hua, AU - Qin,Yue-Lan, AU - Shi,Ze-Ya, AU - Chen,Jin-Hui, AU - Zeng,Min-Jie, AU - Zhou,Wei, AU - Chen,Ru-Qun, AU - Chen,Zhi-Yuan, Y1 - 2019/12/18/ PY - 2019/09/22/received PY - 2019/12/01/accepted PY - 2019/12/20/entrez PY - 2019/12/20/pubmed PY - 2020/5/16/medline KW - Alternate-day fasting KW - Dyslipidaemia KW - Non-alcoholic fatty liver disease KW - Weight loss SP - 219 EP - 219 JF - BMC gastroenterology JO - BMC Gastroenterol VL - 19 IS - 1 N2 - BACKGROUND: Alternate-day fasting (ADF) is a novel diet therapy that may achieve reduction in body weight and improvement of dyslipidaemia, but the impact of this diet on patients with non-alcoholic fatty liver disease (NAFLD) remains unknown. The aim of this study was to evaluate the effects of ADF on the body weight and lipid profile of individuals with NAFLD. METHODS: NAFLD patients (n = 271) were randomised to the ADF group, time-restricted feeding (TRF) group, or the control group and subjected to the respective diet for 12 weeks. Anthropometric measurements (body weight, fat mass/fat-free mass) were performed, and plasma lipids were analysed enzymatically. RESULTS: Within 4 weeks, the body weight decreased significantly (P < 0.001) in the ADF group by 4.56 ± 0.41 kg (6.1 ± 0.5%) and the TRF group by 3.62 ± 0.65 kg (4.83 ± 0.9%) compared to the control group, and it decreased even more after 12 weeks in both groups (ADF: - 4.04 ± 0.54 kg, 5.4 ± 0.7%; TRF: - 3.25 ± 0.67 kg, 4.3 ± 0.9%). Fat mass was significantly reduced by ADF (- 3.49 ± 0.37 kg; 11 ± 1.2%) and TRF (- 2.91 ± 0.41 kg; 9.6 ± 1.3%), with ADF leading to a further reduction in fat mass after 12 weeks (- 3.48 ± 0.38 kg; 11 ± 1.2%). Total cholesterol was significantly decreased at both time points in the ADF group (- 0.91 ± 0.07 mmol/L; 18.5 ± 1.5%) compared to the control and TRF groups. Both ADF (- 0.64 ± 0.06 mmol/L; 25 ± 1.9%) and TRF (0.58 ± 0.07 mmol/L; 20 ± 1.7%) achieved a significant reduction in serum triglycerides (P < 0.001) after 12 weeks. Changes in fat free mass, HDL, LDL, fasting insulin, glucose, liver stiffness, and systolic or diastolic blood pressure did not differ between the groups. CONCLUSIONS: ADF appears to be an effective diet therapy for individuals with NAFLD that can achieve weight loss and improvement of dyslipidaemia within a relatively short period of time (4 to 12 weeks). Potential preventive effects of ADF on cardiovascular disease need to be confirmed by future investigations. TRIAL REGISTRATION: ChiCTR1900024411, this trial was retrospectively registered on July 10, 2019. SN - 1471-230X UR - https://www.unboundmedicine.com/medline/citation/31852444/Effects_of_alternate_day_fasting_on_body_weight_and_dyslipidaemia_in_patients_with_non_alcoholic_fatty_liver_disease:_a_randomised_controlled_trial_ L2 - https://bmcgastroenterol.biomedcentral.com/articles/10.1186/s12876-019-1132-8 DB - PRIME DP - Unbound Medicine ER -