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Anti NMDA receptor antibody encephalitis in Pakistan: Clinicopathological features and treatment outcomes.
J Pak Med Assoc. 2019 Dec; 69(12):1910-1914.JP

Abstract

Anti-NMDA receptor antibody encephalitis (anti-NMDAR Encephalitis) is the most common subtype of autoimmune encephalitis in which IgG antibodies directed against NR1 subunit of NMDA receptors are present. It is a potentially lethal encephalitis which responds favourably to timely immunosuppressive therapy. If untreated, its progression leads from delusions, paranoia, movement disorder, memory deficit and seizures into a state of unresponsiveness with autonomic instability and even death. We present clinicopathological features, treatment and outcomes of eight autoantibodyproven cases of anti-NMDAR Encephalitis. There were 7 females and 1 male with a mean age of 15 years (age range: 1 to 28 years). Clinical features included seizures, altered consciousness, memory deficit, delusions, paranoia and hallucinations. Hyperactivity and irritability were prominent features among the children. Patients treated with immunosuppressive therapy including steroids, IVIg, plasmapheresis and Rituximab, recovered completely within a month of therapy. Whereas patients who received only steroids as immunosuppressive therapy suffered from residual brain damage.

Authors+Show Affiliations

Shifa International Hospital, Shifa Tameer-E-Millat University, Islamabad.Shifa International Hospital, Shifa Tameer-E-Millat University, Islamabad.Shifa International Hospital, Shifa Tameer-E-Millat University, Islamabad.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

31853128

Citation

Sheikh, Shafain, et al. "Anti NMDA Receptor Antibody Encephalitis in Pakistan: Clinicopathological Features and Treatment Outcomes." JPMA. the Journal of the Pakistan Medical Association, vol. 69, no. 12, 2019, pp. 1910-1914.
Sheikh S, Ahmad A, Ahmed TA. Anti NMDA receptor antibody encephalitis in Pakistan: Clinicopathological features and treatment outcomes. J Pak Med Assoc. 2019;69(12):1910-1914.
Sheikh, S., Ahmad, A., & Ahmed, T. A. (2019). Anti NMDA receptor antibody encephalitis in Pakistan: Clinicopathological features and treatment outcomes. JPMA. the Journal of the Pakistan Medical Association, 69(12), 1910-1914. https://doi.org/10.5455/JPMA.300185
Sheikh S, Ahmad A, Ahmed TA. Anti NMDA Receptor Antibody Encephalitis in Pakistan: Clinicopathological Features and Treatment Outcomes. J Pak Med Assoc. 2019;69(12):1910-1914. PubMed PMID: 31853128.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti NMDA receptor antibody encephalitis in Pakistan: Clinicopathological features and treatment outcomes. AU - Sheikh,Shafain, AU - Ahmad,Arsalan, AU - Ahmed,Tahir Aziz, PY - 2019/12/20/entrez PY - 2019/12/20/pubmed PY - 2020/6/17/medline KW - Anti-NMDAR Encephalitis, Immunosuppressive therapy, plasmapheresis, IVIG SP - 1910 EP - 1914 JF - JPMA. The Journal of the Pakistan Medical Association JO - J Pak Med Assoc VL - 69 IS - 12 N2 - Anti-NMDA receptor antibody encephalitis (anti-NMDAR Encephalitis) is the most common subtype of autoimmune encephalitis in which IgG antibodies directed against NR1 subunit of NMDA receptors are present. It is a potentially lethal encephalitis which responds favourably to timely immunosuppressive therapy. If untreated, its progression leads from delusions, paranoia, movement disorder, memory deficit and seizures into a state of unresponsiveness with autonomic instability and even death. We present clinicopathological features, treatment and outcomes of eight autoantibodyproven cases of anti-NMDAR Encephalitis. There were 7 females and 1 male with a mean age of 15 years (age range: 1 to 28 years). Clinical features included seizures, altered consciousness, memory deficit, delusions, paranoia and hallucinations. Hyperactivity and irritability were prominent features among the children. Patients treated with immunosuppressive therapy including steroids, IVIg, plasmapheresis and Rituximab, recovered completely within a month of therapy. Whereas patients who received only steroids as immunosuppressive therapy suffered from residual brain damage. SN - 0030-9982 UR - https://www.unboundmedicine.com/medline/citation/31853128/Anti_NMDA_receptor_antibody_encephalitis_in_Pakistan:_Clinicopathological_features_and_treatment_outcomes_ L2 - http://jpma.org.pk/full_article-text.php?article_id=9452 DB - PRIME DP - Unbound Medicine ER -