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Oral contraceptive agents and breast cancer: a population-based case-control study.
Med J Aust 1988; 149(10):520-6MJ

Abstract

In this population-based case-control study that was conducted in Adelaide, South Australia, and which involved 395 case subjects and 386 control subjects who were aged 20 years to 69 years, the adjusted relative risk of breast cancer for women who had ever used oral contraceptive agents was 1.06 (95% confidence interval [CI], 0.70-1.60). Relative risks that were associated with use of oral contraceptive agents for one month to 18 months and for 19 months or more before a first pregnancy were 1.09 (95% CI, 0.45-2.62) and 1.67 (95% CI, 0.63-4.42), respectively, but the trend was not statistically significant. Relatively-little variation in risk was found in association with the total duration of the use of oral contraceptive agents and with years since the first and the last use of oral contraceptive agents. When the risk of breast cancer in association with the use of oral contraceptive agents was examined across levels of risk factors of breast cancer (history of benign breast disease, family history of breast cancer and parity), the only relative risk which deviated markedly from unity was that which was associated with use of oral contraceptive agents in women with a history of benign breast disease; however, the relative risk of 1.77 (95% CI, 0.35-8.97) was not statistically significant. In conclusion, the results of this study support those of the majority of previous studies in showing no overall relationship between the use of oral contraceptive agents and the risk of breast cancer.

Authors+Show Affiliations

MRC Epidemiology and Medical Care Unit, Northwick Park Hospital, Middlesex, United Kingdom.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3185321

Citation

Rohan, T E., and A J. McMichael. "Oral Contraceptive Agents and Breast Cancer: a Population-based Case-control Study." The Medical Journal of Australia, vol. 149, no. 10, 1988, pp. 520-6.
Rohan TE, McMichael AJ. Oral contraceptive agents and breast cancer: a population-based case-control study. Med J Aust. 1988;149(10):520-6.
Rohan, T. E., & McMichael, A. J. (1988). Oral contraceptive agents and breast cancer: a population-based case-control study. The Medical Journal of Australia, 149(10), pp. 520-6.
Rohan TE, McMichael AJ. Oral Contraceptive Agents and Breast Cancer: a Population-based Case-control Study. Med J Aust. 1988 Nov 21;149(10):520-6. PubMed PMID: 3185321.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral contraceptive agents and breast cancer: a population-based case-control study. AU - Rohan,T E, AU - McMichael,A J, PY - 1988/11/21/pubmed PY - 1988/11/21/medline PY - 1988/11/21/entrez KW - Australia KW - Biology KW - Breast Cancer--etiology KW - Cancer KW - Comparative Studies KW - Contraception KW - Contraceptive Methods--side effects KW - Demographic Factors KW - Developed Countries KW - Diseases KW - Family Planning KW - Neoplasms KW - Oceania KW - Oral Contraceptives--side effects KW - Population KW - Population Dynamics KW - Research Methodology KW - Risk Factors KW - Studies KW - Time Factors SP - 520 EP - 6 JF - The Medical journal of Australia JO - Med. J. Aust. VL - 149 IS - 10 N2 - In this population-based case-control study that was conducted in Adelaide, South Australia, and which involved 395 case subjects and 386 control subjects who were aged 20 years to 69 years, the adjusted relative risk of breast cancer for women who had ever used oral contraceptive agents was 1.06 (95% confidence interval [CI], 0.70-1.60). Relative risks that were associated with use of oral contraceptive agents for one month to 18 months and for 19 months or more before a first pregnancy were 1.09 (95% CI, 0.45-2.62) and 1.67 (95% CI, 0.63-4.42), respectively, but the trend was not statistically significant. Relatively-little variation in risk was found in association with the total duration of the use of oral contraceptive agents and with years since the first and the last use of oral contraceptive agents. When the risk of breast cancer in association with the use of oral contraceptive agents was examined across levels of risk factors of breast cancer (history of benign breast disease, family history of breast cancer and parity), the only relative risk which deviated markedly from unity was that which was associated with use of oral contraceptive agents in women with a history of benign breast disease; however, the relative risk of 1.77 (95% CI, 0.35-8.97) was not statistically significant. In conclusion, the results of this study support those of the majority of previous studies in showing no overall relationship between the use of oral contraceptive agents and the risk of breast cancer. SN - 0025-729X UR - https://www.unboundmedicine.com/medline/citation/3185321/Oral_contraceptive_agents_and_breast_cancer:_a_population_based_case_control_study_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0025-729X&date=1988&volume=149&issue=10&spage=520 DB - PRIME DP - Unbound Medicine ER -