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Segmented retinal layer analysis of chiasmal compressive optic neuropathy in pituitary adenoma patients.
Graefes Arch Clin Exp Ophthalmol. 2020 Feb; 258(2):419-425.GA

Abstract

AIMS

To evaluate changes in the segmented retinal layers of pituitary adenoma (PA) patients and to identify the relationship between these changes and visual function.

METHODS

A total of 47 (PA patients) and 22 (healthy subjects) eyes were reviewed from the medical records. The PA patients performed a visual field (VF) test before surgery and 1 month after surgery. By optical coherence tomography scanning, eight retinal layers were measured: retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer, outer nuclear layer, retinal pigment epithelium, and photoreceptor layer.

RESULTS

The PA group showed reduced RNFL, GCL, and IPL thicknesses (p = 0.004,< 0.001,< 0.001) and thicker INL thickness (p = 0.012) than did the controls. The mean deviation of preoperative VF in the PA group was positively correlated with RNFL, GCL, and IPL thicknesses (R = 0.664, 0.720, 0.664; p < 0.001,< 0.001,< 0.001) and negatively correlated with the INL thickness (R = -0.400; p = 0.010). Among the 47 eyes, 32 eyes (68%) were included for subgroup analysis. Preoperative RNFL, GCL, and IPL thicknesses were thicker in the postoperatively improved VF group (p = 0.019, 0.009, 0.005). The preoperative cutoff values for visual recovery were 23.6 μm for RNFL thickness, 30.6 μm for GCL thickness, and 28.9 μm for IPL thickness.

CONCLUSION

During chiasmal compression, the thickening of the INL has presented in addition to thinning of the inner retinal layers. Also, changes in retinal anatomical structures are related to the extent of VF defect and can be used as a predictor of postoperative visual recovery.

Authors+Show Affiliations

Department of Ophthalmology, SahmYook Medical Center, 82 Mangu-ro, Dongdaemun-gu, Seoul, 02500, Republic of Korea.Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, #222 Banpo-daero, Seocho-gu, Seoul, 06591, Republic of Korea. eyeshin@catholic.ac.kr.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

31853626

Citation

Moon, Ji-Sun, and Sun Young Shin. "Segmented Retinal Layer Analysis of Chiasmal Compressive Optic Neuropathy in Pituitary Adenoma Patients." Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, vol. 258, no. 2, 2020, pp. 419-425.
Moon JS, Shin SY. Segmented retinal layer analysis of chiasmal compressive optic neuropathy in pituitary adenoma patients. Graefes Arch Clin Exp Ophthalmol. 2020;258(2):419-425.
Moon, J. S., & Shin, S. Y. (2020). Segmented retinal layer analysis of chiasmal compressive optic neuropathy in pituitary adenoma patients. Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie, 258(2), 419-425. https://doi.org/10.1007/s00417-019-04560-3
Moon JS, Shin SY. Segmented Retinal Layer Analysis of Chiasmal Compressive Optic Neuropathy in Pituitary Adenoma Patients. Graefes Arch Clin Exp Ophthalmol. 2020;258(2):419-425. PubMed PMID: 31853626.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Segmented retinal layer analysis of chiasmal compressive optic neuropathy in pituitary adenoma patients. AU - Moon,Ji-Sun, AU - Shin,Sun Young, Y1 - 2019/12/18/ PY - 2019/06/27/received PY - 2019/12/03/accepted PY - 2019/11/21/revised PY - 2019/12/20/pubmed PY - 2020/12/2/medline PY - 2019/12/20/entrez KW - Compressive optic neuropathy KW - Pituitary adenoma KW - Segmented retinal layer KW - Spectral-domain optical coherence tomography (SD-OCT) SP - 419 EP - 425 JF - Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie JO - Graefes Arch Clin Exp Ophthalmol VL - 258 IS - 2 N2 - AIMS: To evaluate changes in the segmented retinal layers of pituitary adenoma (PA) patients and to identify the relationship between these changes and visual function. METHODS: A total of 47 (PA patients) and 22 (healthy subjects) eyes were reviewed from the medical records. The PA patients performed a visual field (VF) test before surgery and 1 month after surgery. By optical coherence tomography scanning, eight retinal layers were measured: retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer, outer nuclear layer, retinal pigment epithelium, and photoreceptor layer. RESULTS: The PA group showed reduced RNFL, GCL, and IPL thicknesses (p = 0.004,< 0.001,< 0.001) and thicker INL thickness (p = 0.012) than did the controls. The mean deviation of preoperative VF in the PA group was positively correlated with RNFL, GCL, and IPL thicknesses (R = 0.664, 0.720, 0.664; p < 0.001,< 0.001,< 0.001) and negatively correlated with the INL thickness (R = -0.400; p = 0.010). Among the 47 eyes, 32 eyes (68%) were included for subgroup analysis. Preoperative RNFL, GCL, and IPL thicknesses were thicker in the postoperatively improved VF group (p = 0.019, 0.009, 0.005). The preoperative cutoff values for visual recovery were 23.6 μm for RNFL thickness, 30.6 μm for GCL thickness, and 28.9 μm for IPL thickness. CONCLUSION: During chiasmal compression, the thickening of the INL has presented in addition to thinning of the inner retinal layers. Also, changes in retinal anatomical structures are related to the extent of VF defect and can be used as a predictor of postoperative visual recovery. SN - 1435-702X UR - https://www.unboundmedicine.com/medline/citation/31853626/Segmented_retinal_layer_analysis_of_chiasmal_compressive_optic_neuropathy_in_pituitary_adenoma_patients_ DB - PRIME DP - Unbound Medicine ER -