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Regulation of host immune cells and cytokine production induced by Trichinella spiralis infection.
Parasite 2019; 26:74P

Abstract

The nematode Trichinella spiralis can cause immunoregulation during the early phase of infection. However, previous studies are still insufficient for a full understanding of this phenomenon and its underlying mechanism. In this study, immune cells and cytokine profiles of T. spiralis infected mice were examined by Meso Scale Discovery (MSD) and flow cytometry. The MSD results of the spleen showed that Th1 immunity was inhibited from 6 h to 6 days post-infection (dpi) and the level of Th2 immune response was significantly increased at 6 dpi. The mesenteric lymph node showed a Th1/Th2 mixed immune response from 3 dpi to 6 dpi with a downtrend of Th1 at 6 dpi. Flow cytometry analysis showed that the proportion of Th1 cells of T cells was decreased significantly at 6 h after infection, the proportion of Th2 cells was markedly increased, indicating that Th1 immunity was significantly inhibited at 6 h after infection, and a hybrid immune response based on Th2 type was presented from 30 h to 6 dpi. The immunoregulation effects observed during this study have provided a better understanding of the development of the immune response induced by Trichinella infection.

Authors+Show Affiliations

College of Animal Science and Technology, Inner Mongolia University for Nationalities, Inner Mongolia, 028042 Tongliao, PR China.College of Animal Science and Technology, Inner Mongolia University for Nationalities, Inner Mongolia, 028042 Tongliao, PR China.Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis/College of Veterinary Medicine, Jilin University, 130000 Changchun, PR China.Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis/College of Veterinary Medicine, Jilin University, 130000 Changchun, PR China.Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis/College of Veterinary Medicine, Jilin University, 130000 Changchun, PR China.College of Animal Science and Technology, Inner Mongolia University for Nationalities, Inner Mongolia, 028042 Tongliao, PR China - Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis/College of Veterinary Medicine, Jilin University, 130000 Changchun, PR China.College of Animal Science and Technology, Inner Mongolia University for Nationalities, Inner Mongolia, 028042 Tongliao, PR China.College of Animal Science and Technology, Inner Mongolia University for Nationalities, Inner Mongolia, 028042 Tongliao, PR China.Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis/College of Veterinary Medicine, Jilin University, 130000 Changchun, PR China - Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, Jiangsu, PR China.Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis/College of Veterinary Medicine, Jilin University, 130000 Changchun, PR China.College of Animal Science and Technology, Inner Mongolia University for Nationalities, Inner Mongolia, 028042 Tongliao, PR China - Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis/College of Veterinary Medicine, Jilin University, 130000 Changchun, PR China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31855175

Citation

Song, Yining, et al. "Regulation of Host Immune Cells and Cytokine Production Induced By Trichinella Spiralis Infection." Parasite (Paris, France), vol. 26, 2019, p. 74.
Song Y, Xu J, Wang X, et al. Regulation of host immune cells and cytokine production induced by Trichinella spiralis infection. Parasite. 2019;26:74.
Song, Y., Xu, J., Wang, X., Yang, Y., Bai, X., Pang, J., ... Sun, S. (2019). Regulation of host immune cells and cytokine production induced by Trichinella spiralis infection. Parasite (Paris, France), 26, p. 74. doi:10.1051/parasite/2019074.
Song Y, et al. Regulation of Host Immune Cells and Cytokine Production Induced By Trichinella Spiralis Infection. Parasite. 2019;26:74. PubMed PMID: 31855175.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Regulation of host immune cells and cytokine production induced by Trichinella spiralis infection. AU - Song,Yining, AU - Xu,Jing, AU - Wang,Xuelin, AU - Yang,Yong, AU - Bai,Xue, AU - Pang,Jianda, AU - Wang,Xinrui, AU - Yu,Mingchuan, AU - Liu,Mingyuan, AU - Liu,Xiaolei, AU - Sun,Shumin, Y1 - 2019/12/19/ PY - 2019/07/19/received PY - 2019/12/05/accepted PY - 2019/12/20/entrez PY - 2019/12/20/pubmed PY - 2019/12/20/medline KW - Cytokines KW - Immunoregulation KW - Meso Scale Discovery KW - Trichinella spiralis SP - 74 EP - 74 JF - Parasite (Paris, France) JO - Parasite VL - 26 N2 - The nematode Trichinella spiralis can cause immunoregulation during the early phase of infection. However, previous studies are still insufficient for a full understanding of this phenomenon and its underlying mechanism. In this study, immune cells and cytokine profiles of T. spiralis infected mice were examined by Meso Scale Discovery (MSD) and flow cytometry. The MSD results of the spleen showed that Th1 immunity was inhibited from 6 h to 6 days post-infection (dpi) and the level of Th2 immune response was significantly increased at 6 dpi. The mesenteric lymph node showed a Th1/Th2 mixed immune response from 3 dpi to 6 dpi with a downtrend of Th1 at 6 dpi. Flow cytometry analysis showed that the proportion of Th1 cells of T cells was decreased significantly at 6 h after infection, the proportion of Th2 cells was markedly increased, indicating that Th1 immunity was significantly inhibited at 6 h after infection, and a hybrid immune response based on Th2 type was presented from 30 h to 6 dpi. The immunoregulation effects observed during this study have provided a better understanding of the development of the immune response induced by Trichinella infection. SN - 1776-1042 UR - https://www.unboundmedicine.com/medline/citation/31855175/Regulation_of_host_immune_cells_and_cytokine_production_induced_by_Trichinella_spiralis_infection L2 - http://publications.edpsciences.org/10.1051/parasite/2019074 DB - PRIME DP - Unbound Medicine ER -