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Toxicity comparison of nanopolystyrene with three metal oxide nanoparticles in nematode Caenorhabditis elegans.
Chemosphere. 2020 Apr; 245:125625.C

Abstract

Using Caenorhabditis elegans as an animal model, we compared the toxicity between nanopolystyrene and three metal oxide nanoparticles (NPs) (Al2O3-NPs, TiO2-NPs, and SiO2-NPs). After exposure from L1-larvae to adult day-1, nanopolystyrene (100 μg/L) reduced brood size and induced severe germline apoptosis, and nanopolystyrene (10-100 μg/L) decreased locomotion behavior, induced obvious reactive oxygen species (ROS) production, and activated noticeable mitochondrial unfolded protein response (mt UPR). Using several endpoints (lethality, development, reproduction, and/or locomotion behavior), we found that nanopolystyrene could induce more severe toxicity than SiO2-NPs, although nanopolystyrene did not cause the toxicity comparable to that in Al2O3-NPs or TiO2-NPs exposed nematodes. Our data will be useful for understanding the exposure risk of nanopolystyrene on environmental organisms. Moreover, the detected toxicity difference between nanopolystyrene and three metal oxide NPs were associated with the differences in both induction of oxidative stress and activation of mt UPR in exposed nematodes.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Li D
Key Laboratory of Environmental Medicine Engineering in Ministry of Education, Medical School, Southeast University, Nanjing, 210009, China.
Ji J
Key Laboratory of Environmental Medicine Engineering in Ministry of Education, Medical School, Southeast University, Nanjing, 210009, China.
Yuan Y
Key Laboratory of Environmental Medicine Engineering in Ministry of Education, Medical School, Southeast University, Nanjing, 210009, China.
Wang D
Key Laboratory of Environmental Medicine Engineering in Ministry of Education, Medical School, Southeast University, Nanjing, 210009, China. Electronic address: dayongw@seu.edu.cn.

MeSH

AnimalsApoptosisCaenorhabditis elegansLocomotionMetal NanoparticlesNanoparticlesOxidative StressOxidesPolystyrenesReactive Oxygen SpeciesReproductionUnfolded Protein Response

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

31855754

Citation

Li, Dan, et al. "Toxicity Comparison of Nanopolystyrene With Three Metal Oxide Nanoparticles in Nematode Caenorhabditis Elegans." Chemosphere, vol. 245, 2020, p. 125625.
Li D, Ji J, Yuan Y, et al. Toxicity comparison of nanopolystyrene with three metal oxide nanoparticles in nematode Caenorhabditis elegans. Chemosphere. 2020;245:125625.
Li, D., Ji, J., Yuan, Y., & Wang, D. (2020). Toxicity comparison of nanopolystyrene with three metal oxide nanoparticles in nematode Caenorhabditis elegans. Chemosphere, 245, 125625. https://doi.org/10.1016/j.chemosphere.2019.125625
Li D, et al. Toxicity Comparison of Nanopolystyrene With Three Metal Oxide Nanoparticles in Nematode Caenorhabditis Elegans. Chemosphere. 2020;245:125625. PubMed PMID: 31855754.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Toxicity comparison of nanopolystyrene with three metal oxide nanoparticles in nematode Caenorhabditis elegans. AU - Li,Dan, AU - Ji,Jie, AU - Yuan,Yujie, AU - Wang,Dayong, Y1 - 2019/12/16/ PY - 2019/09/11/received PY - 2019/11/29/revised PY - 2019/12/09/accepted PY - 2019/12/20/pubmed PY - 2020/4/16/medline PY - 2019/12/20/entrez KW - Caenorhabditis elegans KW - Nanoparticles KW - Nanopolystyrene KW - Toxicity comparison SP - 125625 EP - 125625 JF - Chemosphere JO - Chemosphere VL - 245 N2 - Using Caenorhabditis elegans as an animal model, we compared the toxicity between nanopolystyrene and three metal oxide nanoparticles (NPs) (Al2O3-NPs, TiO2-NPs, and SiO2-NPs). After exposure from L1-larvae to adult day-1, nanopolystyrene (100 μg/L) reduced brood size and induced severe germline apoptosis, and nanopolystyrene (10-100 μg/L) decreased locomotion behavior, induced obvious reactive oxygen species (ROS) production, and activated noticeable mitochondrial unfolded protein response (mt UPR). Using several endpoints (lethality, development, reproduction, and/or locomotion behavior), we found that nanopolystyrene could induce more severe toxicity than SiO2-NPs, although nanopolystyrene did not cause the toxicity comparable to that in Al2O3-NPs or TiO2-NPs exposed nematodes. Our data will be useful for understanding the exposure risk of nanopolystyrene on environmental organisms. Moreover, the detected toxicity difference between nanopolystyrene and three metal oxide NPs were associated with the differences in both induction of oxidative stress and activation of mt UPR in exposed nematodes. SN - 1879-1298 UR - https://www.unboundmedicine.com/medline/citation/31855754/Toxicity_comparison_of_nanopolystyrene_with_three_metal_oxide_nanoparticles_in_nematode_Caenorhabditis_elegans_ DB - PRIME DP - Unbound Medicine ER -