Tags

Type your tag names separated by a space and hit enter

Chili Pepper Consumption and Mortality in Italian Adults.
J Am Coll Cardiol. 2019 12 24; 74(25):3139-3149.JACC

Abstract

BACKGROUND

Chili pepper is a usual part of a traditional Mediterranean diet. Yet epidemiological data on the association between chili pepper intake and mortality risk are scarce, with a lack of studies from Mediterranean populations.

OBJECTIVES

This study sought to examine the association between chili pepper consumption and risk of death in a large sample of the adult Italian general population, and to account for biological mediators of the association.

METHODS

Longitudinal analysis was performed on 22,811 men and women enrolled in the Moli-sani Study cohort (2005 to 2010). Chili pepper intake was estimated by the EPIC (European Prospective Investigation Into Cancer) Food Frequency Questionnaire and categorized as none/rare consumption, up to 2 times/week, >2 to ≤4 times/week, and >4 times/week.

RESULTS

Over a median follow-up of 8.2 years, a total of 1,236 deaths were ascertained. Multivariable hazard ratios (HRs) for all-cause and cardiovascular disease (CVD) mortality among participants in the regular (>4 times/week) relative to none/rare intake were 0.77 (95% confidence interval [CI]: 0.66 to 0.90) and 0.66 (95% CI: 0.50 to 0.86), respectively. Regular intake was also inversely associated with ischemic heart disease (HR: 0.56; 95% CI: 0.35 to 0.87) and cerebrovascular (HR: 0.39; 95% CI: 0.20 to 0.75) death risks. The association of chili pepper consumption with total mortality appeared to be stronger in hypertension-free individuals (p for interaction = 0.021). Among known biomarkers of CVD, only serum vitamin D marginally accounted for such associations.

CONCLUSIONS

In a large adult Mediterranean population, regular consumption of chili pepper is associated with a lower risk of total and CVD death independent of CVD risk factors or adherence to a Mediterranean diet. Known biomarkers of CVD risk only marginally mediate the association of chili pepper intake with mortality.

Authors+Show Affiliations

Department of Epidemiology and Prevention, IRCCS Neuromed, Via dell'Elettronica, Pozzilli, Italy. Electronic address: marialaura.bonaccio@neuromed.it.Mediterranea Cardiocentro, Napoli, Italy.Department of Epidemiology and Prevention, IRCCS Neuromed, Via dell'Elettronica, Pozzilli, Italy.Department of Epidemiology and Prevention, IRCCS Neuromed, Via dell'Elettronica, Pozzilli, Italy.Department of Epidemiology and Prevention, IRCCS Neuromed, Via dell'Elettronica, Pozzilli, Italy.Department of Epidemiology and Prevention, IRCCS Neuromed, Via dell'Elettronica, Pozzilli, Italy.Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Roma, Italy.Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Roma, Italy.Department of Epidemiology and Prevention, IRCCS Neuromed, Via dell'Elettronica, Pozzilli, Italy.Department of Epidemiology and Prevention, IRCCS Neuromed, Via dell'Elettronica, Pozzilli, Italy.Department of Epidemiology and Prevention, IRCCS Neuromed, Via dell'Elettronica, Pozzilli, Italy.Department of Epidemiology and Prevention, IRCCS Neuromed, Via dell'Elettronica, Pozzilli, Italy; Department of Medicine and Surgery, Research Center in Epidemiology and Preventive Medicine (EPIMED), University of Insubria, Varese, Italy.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31856971

Citation

Bonaccio, Marialaura, et al. "Chili Pepper Consumption and Mortality in Italian Adults." Journal of the American College of Cardiology, vol. 74, no. 25, 2019, pp. 3139-3149.
Bonaccio M, Di Castelnuovo A, Costanzo S, et al. Chili Pepper Consumption and Mortality in Italian Adults. J Am Coll Cardiol. 2019;74(25):3139-3149.
Bonaccio, M., Di Castelnuovo, A., Costanzo, S., Ruggiero, E., De Curtis, A., Persichillo, M., Tabolacci, C., Facchiano, F., Cerletti, C., Donati, M. B., de Gaetano, G., & Iacoviello, L. (2019). Chili Pepper Consumption and Mortality in Italian Adults. Journal of the American College of Cardiology, 74(25), 3139-3149. https://doi.org/10.1016/j.jacc.2019.09.068
Bonaccio M, et al. Chili Pepper Consumption and Mortality in Italian Adults. J Am Coll Cardiol. 2019 12 24;74(25):3139-3149. PubMed PMID: 31856971.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chili Pepper Consumption and Mortality in Italian Adults. AU - Bonaccio,Marialaura, AU - Di Castelnuovo,Augusto, AU - Costanzo,Simona, AU - Ruggiero,Emilia, AU - De Curtis,Amalia, AU - Persichillo,Mariarosaria, AU - Tabolacci,Claudio, AU - Facchiano,Francesco, AU - Cerletti,Chiara, AU - Donati,Maria Benedetta, AU - de Gaetano,Giovanni, AU - Iacoviello,Licia, AU - ,, PY - 2019/04/30/received PY - 2019/08/29/revised PY - 2019/09/23/accepted PY - 2019/12/21/entrez PY - 2019/12/21/pubmed PY - 2020/5/23/medline KW - Mediterranean diet KW - cardiovascular mortality KW - cerebrovascular mortality KW - chili pepper KW - inflammation KW - risk factors KW - total mortality SP - 3139 EP - 3149 JF - Journal of the American College of Cardiology JO - J. Am. Coll. Cardiol. VL - 74 IS - 25 N2 - BACKGROUND: Chili pepper is a usual part of a traditional Mediterranean diet. Yet epidemiological data on the association between chili pepper intake and mortality risk are scarce, with a lack of studies from Mediterranean populations. OBJECTIVES: This study sought to examine the association between chili pepper consumption and risk of death in a large sample of the adult Italian general population, and to account for biological mediators of the association. METHODS: Longitudinal analysis was performed on 22,811 men and women enrolled in the Moli-sani Study cohort (2005 to 2010). Chili pepper intake was estimated by the EPIC (European Prospective Investigation Into Cancer) Food Frequency Questionnaire and categorized as none/rare consumption, up to 2 times/week, >2 to ≤4 times/week, and >4 times/week. RESULTS: Over a median follow-up of 8.2 years, a total of 1,236 deaths were ascertained. Multivariable hazard ratios (HRs) for all-cause and cardiovascular disease (CVD) mortality among participants in the regular (>4 times/week) relative to none/rare intake were 0.77 (95% confidence interval [CI]: 0.66 to 0.90) and 0.66 (95% CI: 0.50 to 0.86), respectively. Regular intake was also inversely associated with ischemic heart disease (HR: 0.56; 95% CI: 0.35 to 0.87) and cerebrovascular (HR: 0.39; 95% CI: 0.20 to 0.75) death risks. The association of chili pepper consumption with total mortality appeared to be stronger in hypertension-free individuals (p for interaction = 0.021). Among known biomarkers of CVD, only serum vitamin D marginally accounted for such associations. CONCLUSIONS: In a large adult Mediterranean population, regular consumption of chili pepper is associated with a lower risk of total and CVD death independent of CVD risk factors or adherence to a Mediterranean diet. Known biomarkers of CVD risk only marginally mediate the association of chili pepper intake with mortality. SN - 1558-3597 UR - https://www.unboundmedicine.com/medline/citation/31856971/Chili_Pepper_Consumption_and_Mortality_in_Italian_Adults_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735-1097(19)38206-3 DB - PRIME DP - Unbound Medicine ER -