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The effects of isolated soy protein, isolated soy isoflavones and soy protein containing isoflavones on serum lipids in postmenopausal women: A systematic review and meta-analysis.
Crit Rev Food Sci Nutr. 2020; 60(20):3414-3428.CR

Abstract

Background:

Many randomized controlled trials (RCTs) have assessed the effects of soy products on serum lipids. However, the responsible soy components and the magnitude of effects in healthy or hypercholesterolemic postmenopausal women are unclear. This review assessed the quality of these RCTs and estimated the effects of isolated soy protein, isolated soy isoflavones and soy protein containing isoflavones on total cholesterol (TC), LDL-C, HDL-C, triglycerides (TG), Apolipoprotein (Apo) A-1 and Apo B among postmenopausal women.

Design:

Forty-six eligible randomized controlled trials published up to 20 May 2019 were identified from the PubMed, Web of Science and Scopus databases. Weighted mean effect sizes were calculated for net changes in serum lipid concentrations by using random-effect models. Specific subgroup analyses were performed to identify the effect of covariates on serum lipid changes.

Results:

Soy consumption was associated with significant decrease in TG (mean differences (MD): -5.04 mg/dl; 95% CI: -9.95, -0.13; P = 0.044), TC (MD: -3.02 mg/dl; 95% CI: -5.56, -0.47; P = 0.02), LDL-C (MD: -3.27 mg/dl; 95% CI: -6.01, -0.53; P = 0.019) and HDL-C (MD: -2.28 mg/dl; 95% CI: -4.27, -0.29; P = 0.025). The reduction in LDL-C, TG and HDL were larger in subjects consuming isolated soy protein than isolated soy isoflavones. There was a significant decrease in serum TG and HDL levels with dosages of >25 grams per day soy protein rather than lower dosages of soy protein. The reductions in Apo A-1 were significantly larger in hypercholesterolemic subjects than in healthy subjects.

Conclusions:

Isolated soy protein significantly reduced serum TG, TC, LDL-C, HDL-C and Apo-B levels in postmenopausal women. Isolated soy isoflavones had a significant lowering effect on serum TC and Apo B levels. Soy protein containing isoflavones significantly reduced TG, TC, LDL-C and Apo B levels. Therefore, hyperlipidemia risk reduction with soy products is not uniform and strongly depends on the protein and isoflavone content of soy products, duration and dosage of consumption.

Authors+Show Affiliations

Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran, Iran.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

31858808

Citation

Moradi, Maedeh, et al. "The Effects of Isolated Soy Protein, Isolated Soy Isoflavones and Soy Protein Containing Isoflavones On Serum Lipids in Postmenopausal Women: a Systematic Review and Meta-analysis." Critical Reviews in Food Science and Nutrition, vol. 60, no. 20, 2020, pp. 3414-3428.
Moradi M, Daneshzad E, Azadbakht L. The effects of isolated soy protein, isolated soy isoflavones and soy protein containing isoflavones on serum lipids in postmenopausal women: A systematic review and meta-analysis. Crit Rev Food Sci Nutr. 2020;60(20):3414-3428.
Moradi, M., Daneshzad, E., & Azadbakht, L. (2020). The effects of isolated soy protein, isolated soy isoflavones and soy protein containing isoflavones on serum lipids in postmenopausal women: A systematic review and meta-analysis. Critical Reviews in Food Science and Nutrition, 60(20), 3414-3428. https://doi.org/10.1080/10408398.2019.1689097
Moradi M, Daneshzad E, Azadbakht L. The Effects of Isolated Soy Protein, Isolated Soy Isoflavones and Soy Protein Containing Isoflavones On Serum Lipids in Postmenopausal Women: a Systematic Review and Meta-analysis. Crit Rev Food Sci Nutr. 2020;60(20):3414-3428. PubMed PMID: 31858808.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of isolated soy protein, isolated soy isoflavones and soy protein containing isoflavones on serum lipids in postmenopausal women: A systematic review and meta-analysis. AU - Moradi,Maedeh, AU - Daneshzad,Elnaz, AU - Azadbakht,Leila, Y1 - 2019/12/20/ PY - 2019/12/21/pubmed PY - 2020/11/11/medline PY - 2019/12/21/entrez KW - Apo A-1 KW - Apo B KW - HDL-C KW - LDL-C KW - Soybean proteins KW - hyperlipidemias KW - isoflavones KW - lipids KW - lipoproteins KW - meta-analysis KW - postmenopause KW - randomized controlled trials KW - triglycerides SP - 3414 EP - 3428 JF - Critical reviews in food science and nutrition JO - Crit Rev Food Sci Nutr VL - 60 IS - 20 N2 - Background: Many randomized controlled trials (RCTs) have assessed the effects of soy products on serum lipids. However, the responsible soy components and the magnitude of effects in healthy or hypercholesterolemic postmenopausal women are unclear. This review assessed the quality of these RCTs and estimated the effects of isolated soy protein, isolated soy isoflavones and soy protein containing isoflavones on total cholesterol (TC), LDL-C, HDL-C, triglycerides (TG), Apolipoprotein (Apo) A-1 and Apo B among postmenopausal women.Design: Forty-six eligible randomized controlled trials published up to 20 May 2019 were identified from the PubMed, Web of Science and Scopus databases. Weighted mean effect sizes were calculated for net changes in serum lipid concentrations by using random-effect models. Specific subgroup analyses were performed to identify the effect of covariates on serum lipid changes.Results: Soy consumption was associated with significant decrease in TG (mean differences (MD): -5.04 mg/dl; 95% CI: -9.95, -0.13; P = 0.044), TC (MD: -3.02 mg/dl; 95% CI: -5.56, -0.47; P = 0.02), LDL-C (MD: -3.27 mg/dl; 95% CI: -6.01, -0.53; P = 0.019) and HDL-C (MD: -2.28 mg/dl; 95% CI: -4.27, -0.29; P = 0.025). The reduction in LDL-C, TG and HDL were larger in subjects consuming isolated soy protein than isolated soy isoflavones. There was a significant decrease in serum TG and HDL levels with dosages of >25 grams per day soy protein rather than lower dosages of soy protein. The reductions in Apo A-1 were significantly larger in hypercholesterolemic subjects than in healthy subjects.Conclusions: Isolated soy protein significantly reduced serum TG, TC, LDL-C, HDL-C and Apo-B levels in postmenopausal women. Isolated soy isoflavones had a significant lowering effect on serum TC and Apo B levels. Soy protein containing isoflavones significantly reduced TG, TC, LDL-C and Apo B levels. Therefore, hyperlipidemia risk reduction with soy products is not uniform and strongly depends on the protein and isoflavone content of soy products, duration and dosage of consumption. SN - 1549-7852 UR - https://www.unboundmedicine.com/medline/citation/31858808/The_effects_of_isolated_soy_protein_isolated_soy_isoflavones_and_soy_protein_containing_isoflavones_on_serum_lipids_in_postmenopausal_women:_A_systematic_review_and_meta_analysis_ L2 - https://www.tandfonline.com/doi/full/10.1080/10408398.2019.1689097 DB - PRIME DP - Unbound Medicine ER -