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EFFECT OF CHRONIC RENAL DYSFUNCTION ON THE PERMEABILITY OF THE COLON TO WATER AND ELECTROLYTES: EXPERIMENTAL STUDY IN RATS.
Arq Bras Cir Dig. 2019; 32(4):e1472.AB

Abstract

BACKGROUND

Renal insufficiency is a disease that affects several organs by provoking hypervolemia and uremia. The disease reaches more than 500 million people worldwide and few studies bring their influence on the gastrointestinal tract.

AIM

To evaluate the influence of 5/6 nephrectomy-induced hypervolemia on colonic permeability to water and electrolytes.

METHOD

Sixty male Wistar rats weighing between 280-300 g were divided into three groups: 3, 7 and 14 days after nephrectomy, each one having a false-operated/control and partially nephrectomized. For colonic permeability they were submitted to colonic perfusion with a solution of Tyroad containing phenolphthalein. Differences among the concentrations of Na+, K+ and Cl- were used to calculate the rate of colonic permeability for the electrolytes. Phenolphthalein concentrations were used to evaluate the rate of secretion and water absorption.

RESULTS

The colonic secretion of water and electrolytes occurred expressively in the group seven days after nephrectomy. Hemodynamic and biochemical assessments determined the progression of renal failure in all three groups and polyethylene glycol was shown to be effective in reversing the secretory capacity of the colon.

CONCLUSION

Hypervolemia established after 7 days post-nephrectomy 5/6 caused marked colonic secretion for water and electrolytes. The organism presents progressive colonic secretion as the blood volume increases; on the other hand, polyethylene glycol was able to revert this secretory framework of the colon to water and electrolytes by reversing the hypervolemia.

Authors+Show Affiliations

Physiology and Neuroscience Laboratory of the Biotechnology Graduate Program, School of Medicine, Sobral, CE, Brazil.Physiology and Neuroscience Laboratory of the Biotechnology Graduate Program, School of Medicine, Sobral, CE, Brazil.Physiology and Neuroscience Laboratory of the Biotechnology Graduate Program, School of Medicine, Sobral, CE, Brazil.Pharmacology Laboratory of the Federal University of Ceará, Sobral, CE, Brazil.Physiology and Neuroscience Laboratory of the Biotechnology Graduate Program, School of Medicine, Sobral, CE, Brazil.

Pub Type(s)

Journal Article

Language

eng por

PubMed ID

31859925

Citation

Freire, Elionai Gomes, et al. "EFFECT of CHRONIC RENAL DYSFUNCTION ON the PERMEABILITY of the COLON to WATER and ELECTROLYTES: EXPERIMENTAL STUDY in RATS." Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery, vol. 32, no. 4, 2019, pp. e1472.
Freire EG, Albuquerque JCS, Leal IP, et al. EFFECT OF CHRONIC RENAL DYSFUNCTION ON THE PERMEABILITY OF THE COLON TO WATER AND ELECTROLYTES: EXPERIMENTAL STUDY IN RATS. Arq Bras Cir Dig. 2019;32(4):e1472.
Freire, E. G., Albuquerque, J. C. S., Leal, I. P., Sousa, N. A., & Graça, J. R. V. D. (2019). EFFECT OF CHRONIC RENAL DYSFUNCTION ON THE PERMEABILITY OF THE COLON TO WATER AND ELECTROLYTES: EXPERIMENTAL STUDY IN RATS. Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery, 32(4), e1472. https://doi.org/10.1590/0102-672020190001e1472
Freire EG, et al. EFFECT of CHRONIC RENAL DYSFUNCTION ON the PERMEABILITY of the COLON to WATER and ELECTROLYTES: EXPERIMENTAL STUDY in RATS. Arq Bras Cir Dig. 2019;32(4):e1472. PubMed PMID: 31859925.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - EFFECT OF CHRONIC RENAL DYSFUNCTION ON THE PERMEABILITY OF THE COLON TO WATER AND ELECTROLYTES: EXPERIMENTAL STUDY IN RATS. AU - Freire,Elionai Gomes, AU - Albuquerque,José Cirlânio Sousa, AU - Leal,Israel Pinto, AU - Sousa,Nayara Alves, AU - Graça,José Ronaldo Vasconcelos da, Y1 - 2019/12/20/ PY - 2019/03/04/received PY - 2019/07/02/accepted PY - 2019/12/21/entrez PY - 2019/12/21/pubmed PY - 2020/3/11/medline SP - e1472 EP - e1472 JF - Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery JO - Arq Bras Cir Dig VL - 32 IS - 4 N2 - BACKGROUND: Renal insufficiency is a disease that affects several organs by provoking hypervolemia and uremia. The disease reaches more than 500 million people worldwide and few studies bring their influence on the gastrointestinal tract. AIM: To evaluate the influence of 5/6 nephrectomy-induced hypervolemia on colonic permeability to water and electrolytes. METHOD: Sixty male Wistar rats weighing between 280-300 g were divided into three groups: 3, 7 and 14 days after nephrectomy, each one having a false-operated/control and partially nephrectomized. For colonic permeability they were submitted to colonic perfusion with a solution of Tyroad containing phenolphthalein. Differences among the concentrations of Na+, K+ and Cl- were used to calculate the rate of colonic permeability for the electrolytes. Phenolphthalein concentrations were used to evaluate the rate of secretion and water absorption. RESULTS: The colonic secretion of water and electrolytes occurred expressively in the group seven days after nephrectomy. Hemodynamic and biochemical assessments determined the progression of renal failure in all three groups and polyethylene glycol was shown to be effective in reversing the secretory capacity of the colon. CONCLUSION: Hypervolemia established after 7 days post-nephrectomy 5/6 caused marked colonic secretion for water and electrolytes. The organism presents progressive colonic secretion as the blood volume increases; on the other hand, polyethylene glycol was able to revert this secretory framework of the colon to water and electrolytes by reversing the hypervolemia. SN - 2317-6326 UR - https://www.unboundmedicine.com/medline/citation/31859925/EFFECT_OF_CHRONIC_RENAL_DYSFUNCTION_ON_THE_PERMEABILITY_OF_THE_COLON_TO_WATER_AND_ELECTROLYTES:_EXPERIMENTAL_STUDY_IN_RATS L2 - http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-67202019000400306&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -