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Genotoxicity of mixtures of glyphosate with 2,4-dichlorophenoxyacetic acid chemical forms towards Cnesterodon decemmaculatus (Pisces, Poeciliidae).
Environ Sci Pollut Res Int. 2020 Feb; 27(6):6515-6525.ES

Abstract

Acute genotoxicity of commercial glyphosate (GLY) (Credit®)-, 2,4-D-acid (2,4-D) (Dedalo Elite)-, 2,4-D-amine (2,4-D DMA) (Weedar Full®)- and 2,4-D-ester (2,4-D BE) (Herbifen Super®)-based herbicide formulations alone and their combinations were analysed in Cnesterodon decemmaculatus. Mortality was evaluated as a lethal end-point and the single cell gel electrophoresis (SCGE) bioassay was used as a sublethal end-point. LC5096h values for Dedalo Elite was 0.46 mg/L and Herbifen Super® was 2.67 mg/L based on 2,4-D and 2,4-D BE, respectively. Results reveal a higher toxicity exerted on C. decemmaculatus after exposure to 2,4-D- rather than 2,4-D BE-based herbicide formulations. Overall, results demonstrated an enhancement in the genetic damage index committed to an enhancement of damaged erythrocytes of C. decemmaculatus when exposed to Credit®, Dedalo Elite, Weedar Full® and Herbifen Super® at 5% and 10% of LC5096h values alone as well as in their combinations. Overall, the combination of GLY plus 2,4-D or GLY plus 2,4-D DMA showed a synergistic pattern whereas the combination of GLY plus 2,4-D BE was antagonic. Furthermore, this research is pioneer in the assessment of lethality and genotoxicity induced by 2,4-D-, 2,4-D DMA- and 2,4-D BE-based formulations when combined with GLY-based formulated herbicides in fish after they are acutely exposed.

Authors+Show Affiliations

Laboratório de Mutagênese, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Goiás, Brazil.Cátedra de Citología, Facultad de Ciencias Naturales y Museo, Universidad Nacional de La Plata, Calle 64 N° 3, B1904AMA, La Plata, Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.Cátedra de Citología, Facultad de Ciencias Naturales y Museo, Universidad Nacional de La Plata, Calle 64 N° 3, B1904AMA, La Plata, Argentina.Laboratório de Mutagênese, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, Goiás, Brazil.Cátedra de Citología, Facultad de Ciencias Naturales y Museo, Universidad Nacional de La Plata, Calle 64 N° 3, B1904AMA, La Plata, Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.Cátedra de Citología, Facultad de Ciencias Naturales y Museo, Universidad Nacional de La Plata, Calle 64 N° 3, B1904AMA, La Plata, Argentina. marcelo.larramendy@gmail.com. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina. marcelo.larramendy@gmail.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31873893

Citation

Carvalho, Wanessa F., et al. "Genotoxicity of Mixtures of Glyphosate With 2,4-dichlorophenoxyacetic Acid Chemical Forms Towards Cnesterodon Decemmaculatus (Pisces, Poeciliidae)." Environmental Science and Pollution Research International, vol. 27, no. 6, 2020, pp. 6515-6525.
Carvalho WF, Ruiz de Arcaute C, Torres L, et al. Genotoxicity of mixtures of glyphosate with 2,4-dichlorophenoxyacetic acid chemical forms towards Cnesterodon decemmaculatus (Pisces, Poeciliidae). Environ Sci Pollut Res Int. 2020;27(6):6515-6525.
Carvalho, W. F., Ruiz de Arcaute, C., Torres, L., de Melo E Silva, D., Soloneski, S., & Larramendy, M. L. (2020). Genotoxicity of mixtures of glyphosate with 2,4-dichlorophenoxyacetic acid chemical forms towards Cnesterodon decemmaculatus (Pisces, Poeciliidae). Environmental Science and Pollution Research International, 27(6), 6515-6525. https://doi.org/10.1007/s11356-019-07379-x
Carvalho WF, et al. Genotoxicity of Mixtures of Glyphosate With 2,4-dichlorophenoxyacetic Acid Chemical Forms Towards Cnesterodon Decemmaculatus (Pisces, Poeciliidae). Environ Sci Pollut Res Int. 2020;27(6):6515-6525. PubMed PMID: 31873893.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genotoxicity of mixtures of glyphosate with 2,4-dichlorophenoxyacetic acid chemical forms towards Cnesterodon decemmaculatus (Pisces, Poeciliidae). AU - Carvalho,Wanessa F, AU - Ruiz de Arcaute,Celeste, AU - Torres,Luciano, AU - de Melo E Silva,Daniela, AU - Soloneski,Sonia, AU - Larramendy,Marcelo L, Y1 - 2019/12/23/ PY - 2019/09/11/received PY - 2019/12/10/accepted PY - 2019/12/25/pubmed PY - 2020/5/8/medline PY - 2019/12/25/entrez KW - 2,4-D KW - Glyphosate KW - Herbicide mixtures KW - Mortality KW - SCGE (comet) assay SP - 6515 EP - 6525 JF - Environmental science and pollution research international JO - Environ Sci Pollut Res Int VL - 27 IS - 6 N2 - Acute genotoxicity of commercial glyphosate (GLY) (Credit®)-, 2,4-D-acid (2,4-D) (Dedalo Elite)-, 2,4-D-amine (2,4-D DMA) (Weedar Full®)- and 2,4-D-ester (2,4-D BE) (Herbifen Super®)-based herbicide formulations alone and their combinations were analysed in Cnesterodon decemmaculatus. Mortality was evaluated as a lethal end-point and the single cell gel electrophoresis (SCGE) bioassay was used as a sublethal end-point. LC5096h values for Dedalo Elite was 0.46 mg/L and Herbifen Super® was 2.67 mg/L based on 2,4-D and 2,4-D BE, respectively. Results reveal a higher toxicity exerted on C. decemmaculatus after exposure to 2,4-D- rather than 2,4-D BE-based herbicide formulations. Overall, results demonstrated an enhancement in the genetic damage index committed to an enhancement of damaged erythrocytes of C. decemmaculatus when exposed to Credit®, Dedalo Elite, Weedar Full® and Herbifen Super® at 5% and 10% of LC5096h values alone as well as in their combinations. Overall, the combination of GLY plus 2,4-D or GLY plus 2,4-D DMA showed a synergistic pattern whereas the combination of GLY plus 2,4-D BE was antagonic. Furthermore, this research is pioneer in the assessment of lethality and genotoxicity induced by 2,4-D-, 2,4-D DMA- and 2,4-D BE-based formulations when combined with GLY-based formulated herbicides in fish after they are acutely exposed. SN - 1614-7499 UR - https://www.unboundmedicine.com/medline/citation/31873893/Genotoxicity_of_mixtures_of_glyphosate_with_24_dichlorophenoxyacetic_acid_chemical_forms_towards_Cnesterodon_decemmaculatus__Pisces_Poeciliidae__ L2 - https://dx.doi.org/10.1007/s11356-019-07379-x DB - PRIME DP - Unbound Medicine ER -