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Profile of pathogenic proteins in total circulating extracellular vesicles in mild cognitive impairment and during the progression of Alzheimer's disease.
Neurobiol Aging. 2020 02; 86:102-111.NA

Abstract

Accumulating evidence suggests that the propagation of hyperphosphorylation of tau protein and the amyloid-β peptide can be mediated by extracellular vesicles (EVs) and be associated with the onset and the progression of Alzheimer's disease (AD). As EVs may transfer between the brain and the blood, we have thus hypothesized that the total plasma EVs (pEVs) may contain potential markers to predict the mild cognitive impairment (MCI) and AD progression. We have thus quantified AD-related proteins in isolated pEVs from controls, MCI and AD subjects. In pEVs, we observed early changes of total tau (tTau), amyloid precursor protein levels, and phospho-tau (pTau)-T181/tTau ratio from MCI subjects and late increases of Aβ42 and pTau-T181 levels from patients with moderate AD. Interestingly, abnormal amyloid precursor protein levels and pTau-T181/tTau ratio in pEVs demonstrated a high accuracy to define MCI and AD staging. Although larger samples sizes will be needed to generate well-powered investigations, these preliminary results highlighted the potential of AD-related proteins enriched in pEVs as a sensitive tool for differentiating patients with MCI to patients with AD and monitoring AD progression.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Perrotte M
Institut National de La Recherche Scientifique - Centre Armand-Frappier Santé Biotechnologie, Laval, QC, Canada; Institute on Nutrition and Functional Foods, Laval University, Québec, Canada; Quebec Network for Research on Aging, University of Montreal, Montreal, QC, Canada.
Haddad M
Institut National de La Recherche Scientifique - Centre Armand-Frappier Santé Biotechnologie, Laval, QC, Canada; Institute on Nutrition and Functional Foods, Laval University, Québec, Canada.
Le Page A
Department of Medicine, Geriatric Division, Research Center on Aging, University of Sherbrooke, QC, Canada.
Frost EH
Department of Microbiology and Infectiology, Centre de Recherches Cliniques de CHUS, University of Sherbrooke, QC, Canada.
Fulöp T
Department of Medicine, Geriatric Division, Research Center on Aging, University of Sherbrooke, QC, Canada.
Ramassamy C
Institut National de La Recherche Scientifique - Centre Armand-Frappier Santé Biotechnologie, Laval, QC, Canada; Institute on Nutrition and Functional Foods, Laval University, Québec, Canada; Quebec Network for Research on Aging, University of Montreal, Montreal, QC, Canada. Electronic address: Charles.Ramassamy@iaf.inrs.ca.

MeSH

AgedAged, 80 and overAlzheimer DiseaseAmyloid beta-PeptidesBiomarkersBrainCognitive DysfunctionDiagnosis, DifferentialDisease ProgressionExtracellular VesiclesFemaleHumansMalePhosphorylationtau Proteins

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31883770

Citation

Perrotte, Morgane, et al. "Profile of Pathogenic Proteins in Total Circulating Extracellular Vesicles in Mild Cognitive Impairment and During the Progression of Alzheimer's Disease." Neurobiology of Aging, vol. 86, 2020, pp. 102-111.
Perrotte M, Haddad M, Le Page A, et al. Profile of pathogenic proteins in total circulating extracellular vesicles in mild cognitive impairment and during the progression of Alzheimer's disease. Neurobiol Aging. 2020;86:102-111.
Perrotte, M., Haddad, M., Le Page, A., Frost, E. H., Fulöp, T., & Ramassamy, C. (2020). Profile of pathogenic proteins in total circulating extracellular vesicles in mild cognitive impairment and during the progression of Alzheimer's disease. Neurobiology of Aging, 86, 102-111. https://doi.org/10.1016/j.neurobiolaging.2019.10.010
Perrotte M, et al. Profile of Pathogenic Proteins in Total Circulating Extracellular Vesicles in Mild Cognitive Impairment and During the Progression of Alzheimer's Disease. Neurobiol Aging. 2020;86:102-111. PubMed PMID: 31883770.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Profile of pathogenic proteins in total circulating extracellular vesicles in mild cognitive impairment and during the progression of Alzheimer's disease. AU - Perrotte,Morgane, AU - Haddad,Mohamed, AU - Le Page,Aurélie, AU - Frost,Eric H, AU - Fulöp,Tamàs, AU - Ramassamy,Charles, Y1 - 2019/11/15/ PY - 2019/06/07/received PY - 2019/10/20/revised PY - 2019/10/21/accepted PY - 2019/12/31/pubmed PY - 2020/9/8/medline PY - 2019/12/30/entrez KW - APP KW - Amyloid KW - Biomarkers KW - Exosomes KW - MMSE KW - MoCA KW - Tau SP - 102 EP - 111 JF - Neurobiology of aging JO - Neurobiol Aging VL - 86 N2 - Accumulating evidence suggests that the propagation of hyperphosphorylation of tau protein and the amyloid-β peptide can be mediated by extracellular vesicles (EVs) and be associated with the onset and the progression of Alzheimer's disease (AD). As EVs may transfer between the brain and the blood, we have thus hypothesized that the total plasma EVs (pEVs) may contain potential markers to predict the mild cognitive impairment (MCI) and AD progression. We have thus quantified AD-related proteins in isolated pEVs from controls, MCI and AD subjects. In pEVs, we observed early changes of total tau (tTau), amyloid precursor protein levels, and phospho-tau (pTau)-T181/tTau ratio from MCI subjects and late increases of Aβ42 and pTau-T181 levels from patients with moderate AD. Interestingly, abnormal amyloid precursor protein levels and pTau-T181/tTau ratio in pEVs demonstrated a high accuracy to define MCI and AD staging. Although larger samples sizes will be needed to generate well-powered investigations, these preliminary results highlighted the potential of AD-related proteins enriched in pEVs as a sensitive tool for differentiating patients with MCI to patients with AD and monitoring AD progression. SN - 1558-1497 UR - https://www.unboundmedicine.com/medline/citation/31883770/Profile_of_pathogenic_proteins_in_total_circulating_extracellular_vesicles_in_mild_cognitive_impairment_and_during_the_progression_of_Alzheimer's_disease_ DB - PRIME DP - Unbound Medicine ER -