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The Prevalence of Dementia: A Systematic Review and Meta-Analysis.
J Alzheimers Dis. 2020; 73(3):1157-1166.JA

Abstract

Dementia is a severe neurodegenerative disorder and it can be categorized into several subtypes by different pathogenic causes. We sought to comprehensively analyzed the prevalence of dementia from perspectives of geographic region (Asia, Africa, South America, and Europe/North America), age, and gender. We searched PubMed and EMBASE for relevant articles on dementia published from January 1985 to August 2019. In these studies, analyses were stratified by geographic region, age, and gender. Meta-regression was conducted to identify if there were significant differences between groups. We included forty-seven studies. Among the individuals aged 50 and over in the community, the pooled prevalence for all-cause dementia, Alzheimer's disease, and vascular dementia were 697 (CI95%: 546-864) per 10,000 persons, 324 (CI95%: 228-460) per 10,000 persons, and 116 (CI95%: 86-157) per 10,000 persons, respectively. In our study, the prevalence of all-type dementia in individuals aged 100 years and older (6,592 per 10,000 cases) is 244 times higher than in those aged 50-59 (27 per 10,000 cases). The number of people living with dementia approximately doubles every five years. The prevalence was greater in women than in men (788 cases versus 561 cases per 10,000 persons) in overall analysis. In individuals aged 60 to 69 years, AD prevalence in females was 1.9 times greater than that in males (108 cases versus 56 cases per 10,000 persons), while the prevalence of VaD was 1.8 times greater in males than in females (56 cases versus 32 cases per 10,000 persons). Prevalence rate was higher in Europe and North America than in Asia, Africa, and South America.

Authors+Show Affiliations

Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing, China.Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.Clinical Research Center, Qingdao Municipal Hospital, Qingdao University, Qingdao, China.Department of Neurology & Institute of Neurology, WHO Collaborating Center for Research and Training in Neurosciences, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.Department of Neurology, Qingdao Municipal Hospital, Nanjing Medical University, Nanjing, China.Department of Neurology & Institute of Neurology, WHO Collaborating Center for Research and Training in Neurosciences, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review

Language

eng

PubMed ID

31884487

Citation

Cao, Qing, et al. "The Prevalence of Dementia: a Systematic Review and Meta-Analysis." Journal of Alzheimer's Disease : JAD, vol. 73, no. 3, 2020, pp. 1157-1166.
Cao Q, Tan CC, Xu W, et al. The Prevalence of Dementia: A Systematic Review and Meta-Analysis. J Alzheimers Dis. 2020;73(3):1157-1166.
Cao, Q., Tan, C. C., Xu, W., Hu, H., Cao, X. P., Dong, Q., Tan, L., & Yu, J. T. (2020). The Prevalence of Dementia: A Systematic Review and Meta-Analysis. Journal of Alzheimer's Disease : JAD, 73(3), 1157-1166. https://doi.org/10.3233/JAD-191092
Cao Q, et al. The Prevalence of Dementia: a Systematic Review and Meta-Analysis. J Alzheimers Dis. 2020;73(3):1157-1166. PubMed PMID: 31884487.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Prevalence of Dementia: A Systematic Review and Meta-Analysis. AU - Cao,Qing, AU - Tan,Chen-Chen, AU - Xu,Wei, AU - Hu,Hao, AU - Cao,Xi-Peng, AU - Dong,Qiang, AU - Tan,Lan, AU - Yu,Jin-Tai, PY - 2019/12/31/pubmed PY - 2021/5/11/medline PY - 2019/12/30/entrez KW - Alzheimer’s disease KW - dementia KW - prevalence KW - vascular dementia SP - 1157 EP - 1166 JF - Journal of Alzheimer's disease : JAD JO - J Alzheimers Dis VL - 73 IS - 3 N2 - Dementia is a severe neurodegenerative disorder and it can be categorized into several subtypes by different pathogenic causes. We sought to comprehensively analyzed the prevalence of dementia from perspectives of geographic region (Asia, Africa, South America, and Europe/North America), age, and gender. We searched PubMed and EMBASE for relevant articles on dementia published from January 1985 to August 2019. In these studies, analyses were stratified by geographic region, age, and gender. Meta-regression was conducted to identify if there were significant differences between groups. We included forty-seven studies. Among the individuals aged 50 and over in the community, the pooled prevalence for all-cause dementia, Alzheimer's disease, and vascular dementia were 697 (CI95%: 546-864) per 10,000 persons, 324 (CI95%: 228-460) per 10,000 persons, and 116 (CI95%: 86-157) per 10,000 persons, respectively. In our study, the prevalence of all-type dementia in individuals aged 100 years and older (6,592 per 10,000 cases) is 244 times higher than in those aged 50-59 (27 per 10,000 cases). The number of people living with dementia approximately doubles every five years. The prevalence was greater in women than in men (788 cases versus 561 cases per 10,000 persons) in overall analysis. In individuals aged 60 to 69 years, AD prevalence in females was 1.9 times greater than that in males (108 cases versus 56 cases per 10,000 persons), while the prevalence of VaD was 1.8 times greater in males than in females (56 cases versus 32 cases per 10,000 persons). Prevalence rate was higher in Europe and North America than in Asia, Africa, and South America. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/31884487/The_Prevalence_of_Dementia:_A_Systematic_Review_and_Meta_Analysis_ L2 - https://content.iospress.com/openurl?genre=article&id=doi:10.3233/JAD-191092 DB - PRIME DP - Unbound Medicine ER -