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Denture use and osteoradionecrosis following radiotherapy for head and neck cancer: A systematic review.
Gerodontology. 2020 Jun; 37(2):102-109.G

Abstract

BACKGROUND

It is strongly recommended to extract teeth with poor prognosis in head and neck cancer (HaNC) patients prior starting treatment with radiotherapy to avoid need for extraction post-radiotherapy and prevent development of osteoradionecrosis (ORN). Dental extraction means that patients are often left with insufficient teeth leading to psychological problems and reducing their quality of life post-radiotherapy. Some clinicians do not advocate the use of dentures in HaNC patients claiming that dentures might lead to soft tissue irritation followed by ORN when constructed on irradiated jaws.

AIMS

This systematic review aimed to investigate the existing evidence regarding the impact of denture use on the development of ORN in HaNC patients post-radiotherapy.

METHODS

This systematic review followed the Preferred Reporting Item for Systematic Review and Meta-analyses (PRISMA) guideline. Three database systems were used: Ovid Medline, EMBASE and PsycINFO. PROSPERO was searched for ongoing or recently completed systematic reviews. The https://ClinicalTrials.gov was searched for ongoing or recently completed trials. The Joanna Briggs Institute critical appraisal tools were used to assess quality of studies being reviewed.

RESULTS

Only three retrospective case-control studies were included. Numbers of participants included in the three studies are limited with incomparable types of mucosal dentures. None of the studies described the method of measurement of the exposure (denture use) in a standard, validated and reliable way.

CONCLUSION

The three included studies suggested no link between denture use and development of ORN. However, very little evidence exists and the robustness of the studies is questionable. Well-powered studies are needed.

Authors+Show Affiliations

Faculty of Dentistry, Oral and Craniofacial Sciences, Centre for Oral, Clinical and Translational Science, King's College London, London, UK. Department of Basic and Clinical Oral Sciences, Faculty of Dentistry, Umm Al-Qura University, Makkah, Saudi Arabia. Department of Sedation and Special Care Dentistry, Guy's & St Thomas' Foundation Trust, London, UK.Department of Sedation and Special Care Dentistry, Guy's & St Thomas' Foundation Trust, London, UK.Faculty of Dentistry, Oral and Craniofacial Sciences, Centre for Host Microbiome Interactions, King's College London, London, UK.Faculty of Dentistry, Oral and Craniofacial Sciences, Centre for Oral, Clinical and Translational Science, King's College London, London, UK.

Pub Type(s)

Journal Article
Review
Systematic Review

Language

eng

PubMed ID

31886587

Citation

Abed, Hassan, et al. "Denture Use and Osteoradionecrosis Following Radiotherapy for Head and Neck Cancer: a Systematic Review." Gerodontology, vol. 37, no. 2, 2020, pp. 102-109.
Abed H, Burke M, Scambler S, et al. Denture use and osteoradionecrosis following radiotherapy for head and neck cancer: A systematic review. Gerodontology. 2020;37(2):102-109.
Abed, H., Burke, M., Scambler, S., & Scott, S. E. (2020). Denture use and osteoradionecrosis following radiotherapy for head and neck cancer: A systematic review. Gerodontology, 37(2), 102-109. https://doi.org/10.1111/ger.12456
Abed H, et al. Denture Use and Osteoradionecrosis Following Radiotherapy for Head and Neck Cancer: a Systematic Review. Gerodontology. 2020;37(2):102-109. PubMed PMID: 31886587.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Denture use and osteoradionecrosis following radiotherapy for head and neck cancer: A systematic review. AU - Abed,Hassan, AU - Burke,Mary, AU - Scambler,Sasha, AU - Scott,Suzanne E, Y1 - 2019/12/30/ PY - 2019/07/25/received PY - 2019/11/27/revised PY - 2019/12/08/accepted PY - 2019/12/31/pubmed PY - 2020/5/19/medline PY - 2019/12/31/entrez KW - dentures KW - head and neck neoplasms KW - osteoradionecrosis KW - radiotherapy KW - teeth extraction SP - 102 EP - 109 JF - Gerodontology JO - Gerodontology VL - 37 IS - 2 N2 - BACKGROUND: It is strongly recommended to extract teeth with poor prognosis in head and neck cancer (HaNC) patients prior starting treatment with radiotherapy to avoid need for extraction post-radiotherapy and prevent development of osteoradionecrosis (ORN). Dental extraction means that patients are often left with insufficient teeth leading to psychological problems and reducing their quality of life post-radiotherapy. Some clinicians do not advocate the use of dentures in HaNC patients claiming that dentures might lead to soft tissue irritation followed by ORN when constructed on irradiated jaws. AIMS: This systematic review aimed to investigate the existing evidence regarding the impact of denture use on the development of ORN in HaNC patients post-radiotherapy. METHODS: This systematic review followed the Preferred Reporting Item for Systematic Review and Meta-analyses (PRISMA) guideline. Three database systems were used: Ovid Medline, EMBASE and PsycINFO. PROSPERO was searched for ongoing or recently completed systematic reviews. The https://ClinicalTrials.gov was searched for ongoing or recently completed trials. The Joanna Briggs Institute critical appraisal tools were used to assess quality of studies being reviewed. RESULTS: Only three retrospective case-control studies were included. Numbers of participants included in the three studies are limited with incomparable types of mucosal dentures. None of the studies described the method of measurement of the exposure (denture use) in a standard, validated and reliable way. CONCLUSION: The three included studies suggested no link between denture use and development of ORN. However, very little evidence exists and the robustness of the studies is questionable. Well-powered studies are needed. SN - 1741-2358 UR - https://www.unboundmedicine.com/medline/citation/31886587/Denture_use_and_osteoradionecrosis_following_radiotherapy_for_head_and_neck_cancer:_A_systematic_review L2 - https://doi.org/10.1111/ger.12456 DB - PRIME DP - Unbound Medicine ER -