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Glycan Mimetics from Natural Products: New Therapeutic Opportunities for Neurodegenerative Disease.
Molecules. 2019 Dec 16; 24(24)M

Abstract

Neurodegenerative diseases (NDs) affect millions of people worldwide. Characterized by the functional loss and death of neurons, NDs lead to symptoms (dementia and seizures) that affect the daily lives of patients. In spite of extensive research into NDs, the number of approved drugs for their treatment remains limited. There is therefore an urgent need to develop new approaches for the prevention and treatment of NDs. Glycans (carbohydrate chains) are ubiquitous, abundant, and structural complex natural biopolymers. Glycans often covalently attach to proteins and lipids to regulate cellular recognition, adhesion, and signaling. The importance of glycans in both the developing and mature nervous system is well characterized. Moreover, glycan dysregulation has been observed in NDs such as Alzheimer's disease (AD), Huntington's disease (HD), Parkinson's disease (PD), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS). Therefore, glycans are promising but underexploited therapeutic targets. In this review, we summarize the current understanding of glycans in NDs. We also discuss a number of natural products that functionally mimic glycans to protect neurons, which therefore represent promising new therapeutic approaches for patients with NDs.

Authors+Show Affiliations

Development and Stem Cells Program, Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria 3800, Australia.Development and Stem Cells Program, Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria 3800, Australia.Development and Stem Cells Program, Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria 3800, Australia.Development and Stem Cells Program, Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria 3800, Australia.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31888221

Citation

Wang, Wenyue, et al. "Glycan Mimetics From Natural Products: New Therapeutic Opportunities for Neurodegenerative Disease." Molecules (Basel, Switzerland), vol. 24, no. 24, 2019.
Wang W, Gopal S, Pocock R, et al. Glycan Mimetics from Natural Products: New Therapeutic Opportunities for Neurodegenerative Disease. Molecules. 2019;24(24).
Wang, W., Gopal, S., Pocock, R., & Xiao, Z. (2019). Glycan Mimetics from Natural Products: New Therapeutic Opportunities for Neurodegenerative Disease. Molecules (Basel, Switzerland), 24(24). https://doi.org/10.3390/molecules24244604
Wang W, et al. Glycan Mimetics From Natural Products: New Therapeutic Opportunities for Neurodegenerative Disease. Molecules. 2019 Dec 16;24(24) PubMed PMID: 31888221.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glycan Mimetics from Natural Products: New Therapeutic Opportunities for Neurodegenerative Disease. AU - Wang,Wenyue, AU - Gopal,Sandeep, AU - Pocock,Roger, AU - Xiao,Zhicheng, Y1 - 2019/12/16/ PY - 2019/09/26/received PY - 2019/12/12/revised PY - 2019/12/13/accepted PY - 2020/1/1/entrez PY - 2020/1/1/pubmed PY - 2020/5/23/medline KW - glycans KW - glycomimetics KW - natural products KW - neurodegenerative disease KW - therapeutic JF - Molecules (Basel, Switzerland) JO - Molecules VL - 24 IS - 24 N2 - Neurodegenerative diseases (NDs) affect millions of people worldwide. Characterized by the functional loss and death of neurons, NDs lead to symptoms (dementia and seizures) that affect the daily lives of patients. In spite of extensive research into NDs, the number of approved drugs for their treatment remains limited. There is therefore an urgent need to develop new approaches for the prevention and treatment of NDs. Glycans (carbohydrate chains) are ubiquitous, abundant, and structural complex natural biopolymers. Glycans often covalently attach to proteins and lipids to regulate cellular recognition, adhesion, and signaling. The importance of glycans in both the developing and mature nervous system is well characterized. Moreover, glycan dysregulation has been observed in NDs such as Alzheimer's disease (AD), Huntington's disease (HD), Parkinson's disease (PD), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS). Therefore, glycans are promising but underexploited therapeutic targets. In this review, we summarize the current understanding of glycans in NDs. We also discuss a number of natural products that functionally mimic glycans to protect neurons, which therefore represent promising new therapeutic approaches for patients with NDs. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/31888221/Glycan_Mimetics_from_Natural_Products:_New_Therapeutic_Opportunities_for_Neurodegenerative_Disease_ DB - PRIME DP - Unbound Medicine ER -