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Gestational exposure to the cannabinoid WIN 55,212-2 and its effect on the innate intestinal immune response.
Sci Rep 2019; 9(1):20340SR

Abstract

The consequences of marijuana consumption during pregnancy and its effects on the function of the immune system have been little studied. Marijuana is one of the most consumed recreational drugs among pregnant women, and it is known that gestational exposure to marijuana can have serious effects on the offspring after birth. In this study, we challenged the immune system of Wistar rats by infecting them with the parasitic nematode Trichinella spiralis. A treatment group of these animals was prenatally exposed to the cannabinoid WIN 55,212-2; a control group was not exposed. At 5 days of infection, the treated animals were less effective in eliminating intestinal parasites; moreover, this effect was correlated with a deficiency in mucus production, lower recruitment of eosinophils in the duodenum, and a reduced percentage of Tγδ and NK cells. In conclusion, the gestational administration of the synthetic cannabinoid WIN 55,212-2 induces lasting changes to the function of the immune system against infection with T. spiralis in male Wistar rats, making them more susceptible to infection.

Authors+Show Affiliations

Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico.Departamento de Biología Celular y Tisular, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.Grupo de Neurociencias, Laboratorio de Cannabinoides, Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico. jmontor66@biomedicas.unam.mx.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31889093

Citation

Hernández-Cervantes, Rosalía, et al. "Gestational Exposure to the Cannabinoid WIN 55,212-2 and Its Effect On the Innate Intestinal Immune Response." Scientific Reports, vol. 9, no. 1, 2019, p. 20340.
Hernández-Cervantes R, Pérez-Torres A, Prospéro-García Ó, et al. Gestational exposure to the cannabinoid WIN 55,212-2 and its effect on the innate intestinal immune response. Sci Rep. 2019;9(1):20340.
Hernández-Cervantes, R., Pérez-Torres, A., Prospéro-García, Ó., & Morales Montor, J. (2019). Gestational exposure to the cannabinoid WIN 55,212-2 and its effect on the innate intestinal immune response. Scientific Reports, 9(1), p. 20340. doi:10.1038/s41598-019-56653-y.
Hernández-Cervantes R, et al. Gestational Exposure to the Cannabinoid WIN 55,212-2 and Its Effect On the Innate Intestinal Immune Response. Sci Rep. 2019 Dec 30;9(1):20340. PubMed PMID: 31889093.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gestational exposure to the cannabinoid WIN 55,212-2 and its effect on the innate intestinal immune response. AU - Hernández-Cervantes,Rosalía, AU - Pérez-Torres,Armando, AU - Prospéro-García,Óscar, AU - Morales Montor,Jorge, Y1 - 2019/12/30/ PY - 2019/05/16/received PY - 2019/12/16/accepted PY - 2020/1/1/entrez PY - 2020/1/1/pubmed PY - 2020/1/1/medline SP - 20340 EP - 20340 JF - Scientific reports JO - Sci Rep VL - 9 IS - 1 N2 - The consequences of marijuana consumption during pregnancy and its effects on the function of the immune system have been little studied. Marijuana is one of the most consumed recreational drugs among pregnant women, and it is known that gestational exposure to marijuana can have serious effects on the offspring after birth. In this study, we challenged the immune system of Wistar rats by infecting them with the parasitic nematode Trichinella spiralis. A treatment group of these animals was prenatally exposed to the cannabinoid WIN 55,212-2; a control group was not exposed. At 5 days of infection, the treated animals were less effective in eliminating intestinal parasites; moreover, this effect was correlated with a deficiency in mucus production, lower recruitment of eosinophils in the duodenum, and a reduced percentage of Tγδ and NK cells. In conclusion, the gestational administration of the synthetic cannabinoid WIN 55,212-2 induces lasting changes to the function of the immune system against infection with T. spiralis in male Wistar rats, making them more susceptible to infection. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/31889093/Gestational_exposure_to_the_cannabinoid_WIN_55,212-2_and_its_effect_on_the_innate_intestinal_immune_response L2 - http://dx.doi.org/10.1038/s41598-019-56653-y DB - PRIME DP - Unbound Medicine ER -