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Alternate day fasting combined with a low-carbohydrate diet for weight loss, weight maintenance, and metabolic disease risk reduction.
Obes Sci Pract. 2019 Dec; 5(6):531-539.OS

Abstract

Objective

Alternate day fasting (ADF) is a popular weight loss regimen. Whether carbohydrate restriction can enhance the weight loss achieved with ADF remains unclear. Accordingly, this study examined the effect of ADF combined with a low-carbohydrate diet on body weight and metabolic disease risk factors.

Methods

Adults with obesity (n = 31) participated in ADF (600 kcal "fast day" alternated with an ad libitum "feast day") with a low-carbohydrate background diet (30% carbohydrates, 35% protein, and 35% fat). The 6-month trial consisted of a 3-month weight loss period followed by a 3-month weight maintenance period.

Results

Body weight decreased (-5.5 ± 0.5%; P < .001) during the weight loss period (month 0-3) but remained stable (P = .57) during the weight maintenance period (month 4-6). Net weight loss by month 6 was -6.3 ± 1.0%. Fat mass was reduced (P < .01) by month 6, while lean mass and visceral fat mass remained unchanged. Total cholesterol and low-density lipoprotein (LDL) cholesterol levels decreased (P < .05) by -6 ± 2% and - 8 ± 3%, respectively, by month 6. Systolic blood pressure was also reduced (P = .03) by -7 ± 3 mm Hg. Fasting insulin decreased (P = .03) by -24 ± 8% by month 6 relative to baseline. High-density lipoprotein (HDL) cholesterol, triglycerides, diastolic blood pressure, heart rate, fasting glucose, homeostatic model assessment of insulin resistance (HOMA-IR), and haemoglobin A1C (HbA1c) remained unchanged.

Conclusions

These findings suggest that ADF combined with a low-carbohydrate diet is effective for weight loss, weight maintenance, and improving certain metabolic disease risk factors such as LDL cholesterol, blood pressure, and fasting insulin. While these preliminary findings are promising, they still require confirmation by a randomized control trial.

Authors+Show Affiliations

Department of Kinesiology and Nutrition University of Illinois at Chicago Chicago Illinois.Department of Kinesiology and Nutrition University of Illinois at Chicago Chicago Illinois.Department of Kinesiology and Nutrition University of Illinois at Chicago Chicago Illinois.Department of Kinesiology and Nutrition University of Illinois at Chicago Chicago Illinois.Department of Kinesiology and Nutrition University of Illinois at Chicago Chicago Illinois.Department of Kinesiology and Nutrition University of Illinois at Chicago Chicago Illinois.Department of Kinesiology and Nutrition University of Illinois at Chicago Chicago Illinois.Department of Kinesiology and Nutrition University of Illinois at Chicago Chicago Illinois.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31890243

Citation

Kalam, Faiza, et al. "Alternate Day Fasting Combined With a Low-carbohydrate Diet for Weight Loss, Weight Maintenance, and Metabolic Disease Risk Reduction." Obesity Science & Practice, vol. 5, no. 6, 2019, pp. 531-539.
Kalam F, Gabel K, Cienfuegos S, et al. Alternate day fasting combined with a low-carbohydrate diet for weight loss, weight maintenance, and metabolic disease risk reduction. Obes Sci Pract. 2019;5(6):531-539.
Kalam, F., Gabel, K., Cienfuegos, S., Wiseman, E., Ezpeleta, M., Steward, M., Pavlou, V., & Varady, K. A. (2019). Alternate day fasting combined with a low-carbohydrate diet for weight loss, weight maintenance, and metabolic disease risk reduction. Obesity Science & Practice, 5(6), 531-539. https://doi.org/10.1002/osp4.367
Kalam F, et al. Alternate Day Fasting Combined With a Low-carbohydrate Diet for Weight Loss, Weight Maintenance, and Metabolic Disease Risk Reduction. Obes Sci Pract. 2019;5(6):531-539. PubMed PMID: 31890243.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alternate day fasting combined with a low-carbohydrate diet for weight loss, weight maintenance, and metabolic disease risk reduction. AU - Kalam,Faiza, AU - Gabel,Kelsey, AU - Cienfuegos,Sofia, AU - Wiseman,Eric, AU - Ezpeleta,Mark, AU - Steward,Malik, AU - Pavlou,Vasiliki, AU - Varady,Krista A, Y1 - 2019/09/13/ PY - 2019/08/08/received PY - 2019/08/26/revised PY - 2019/08/27/accepted PY - 2020/1/1/entrez PY - 2020/1/1/pubmed PY - 2020/1/1/medline KW - alternate day fasting KW - body weight KW - low‐carbohydrate diet KW - obesity SP - 531 EP - 539 JF - Obesity science & practice JO - Obes Sci Pract VL - 5 IS - 6 N2 - Objective: Alternate day fasting (ADF) is a popular weight loss regimen. Whether carbohydrate restriction can enhance the weight loss achieved with ADF remains unclear. Accordingly, this study examined the effect of ADF combined with a low-carbohydrate diet on body weight and metabolic disease risk factors. Methods: Adults with obesity (n = 31) participated in ADF (600 kcal "fast day" alternated with an ad libitum "feast day") with a low-carbohydrate background diet (30% carbohydrates, 35% protein, and 35% fat). The 6-month trial consisted of a 3-month weight loss period followed by a 3-month weight maintenance period. Results: Body weight decreased (-5.5 ± 0.5%; P < .001) during the weight loss period (month 0-3) but remained stable (P = .57) during the weight maintenance period (month 4-6). Net weight loss by month 6 was -6.3 ± 1.0%. Fat mass was reduced (P < .01) by month 6, while lean mass and visceral fat mass remained unchanged. Total cholesterol and low-density lipoprotein (LDL) cholesterol levels decreased (P < .05) by -6 ± 2% and - 8 ± 3%, respectively, by month 6. Systolic blood pressure was also reduced (P = .03) by -7 ± 3 mm Hg. Fasting insulin decreased (P = .03) by -24 ± 8% by month 6 relative to baseline. High-density lipoprotein (HDL) cholesterol, triglycerides, diastolic blood pressure, heart rate, fasting glucose, homeostatic model assessment of insulin resistance (HOMA-IR), and haemoglobin A1C (HbA1c) remained unchanged. Conclusions: These findings suggest that ADF combined with a low-carbohydrate diet is effective for weight loss, weight maintenance, and improving certain metabolic disease risk factors such as LDL cholesterol, blood pressure, and fasting insulin. While these preliminary findings are promising, they still require confirmation by a randomized control trial. SN - 2055-2238 UR - https://www.unboundmedicine.com/medline/citation/31890243/Alternate_day_fasting_combined_with_a_low_carbohydrate_diet_for_weight_loss_weight_maintenance_and_metabolic_disease_risk_reduction_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31890243/ DB - PRIME DP - Unbound Medicine ER -
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