Tags

Type your tag names separated by a space and hit enter

High trait impulsivity potentiates the effects of chronic pain on impulsive behavior.
Neurobiol Pain. 2020 Jan-Jul; 7:100042.NP

Abstract

Preclinical studies on impulsive decision-making in chronic pain conditions are sparse and often contradictory. Outbred rat populations are heterogeneous regarding trait impulsivity manifestations and therefore we hypothesized that chronic pain-related alterations depend on individual traits. To test this hypothesis, we used male Wistar-Han rats in two independent experiments. Firstly, we tested the impact of spared nerve injury (SNI) in impulsive behavior evaluated by the variable delay-to-signal test (VDS). In the second experiment, SNI impact on impulsivity was again tested, but in groups previously categorized as high (HI) and low (LI) trait impulsivity in the VDS. Results showed that in an heterogenous population SNI-related impact on motor impulsivity and delay intolerance cannot be detected. However, when baseline impulsivity was considered, HI showed a significantly higher delay intolerance than the respective controls more prevalent in left-lesioned animals and appearing to result from a response correction on prematurity from VDS I to VDS II, which was present in Sham and right-lesioned animals. In conclusion, baseline differences should be more often considered when analyzing chronic pain impact. While this study pertained to impulsive behavior, other reports indicate that this can be generalized to other behavioral dimensions and that trait differences can influence not only the manifestation of comorbid behaviors but also pain itself in a complex and not totally understood manner.

Authors+Show Affiliations

Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal. ICVS/3B's - PT Government Associate Laboratory, Braga Guimarães, Portugal.Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal. ICVS/3B's - PT Government Associate Laboratory, Braga Guimarães, Portugal.Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal. ICVS/3B's - PT Government Associate Laboratory, Braga Guimarães, Portugal.Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal. ICVS/3B's - PT Government Associate Laboratory, Braga Guimarães, Portugal.Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal. ICVS/3B's - PT Government Associate Laboratory, Braga Guimarães, Portugal.Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Campus Gualtar, 4710-057 Braga, Portugal. ICVS/3B's - PT Government Associate Laboratory, Braga Guimarães, Portugal.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31890992

Citation

Cunha, Ana Margarida, et al. "High Trait Impulsivity Potentiates the Effects of Chronic Pain On Impulsive Behavior." Neurobiology of Pain (Cambridge, Mass.), vol. 7, 2020, p. 100042.
Cunha AM, Esteves M, Pereira-Mendes J, et al. High trait impulsivity potentiates the effects of chronic pain on impulsive behavior. Neurobiol Pain. 2020;7:100042.
Cunha, A. M., Esteves, M., Pereira-Mendes, J., Guimarães, M. R., Almeida, A., & Leite-Almeida, H. (2020). High trait impulsivity potentiates the effects of chronic pain on impulsive behavior. Neurobiology of Pain (Cambridge, Mass.), 7, 100042. https://doi.org/10.1016/j.ynpai.2019.100042
Cunha AM, et al. High Trait Impulsivity Potentiates the Effects of Chronic Pain On Impulsive Behavior. Neurobiol Pain. 2020 Jan-Jul;7:100042. PubMed PMID: 31890992.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High trait impulsivity potentiates the effects of chronic pain on impulsive behavior. AU - Cunha,Ana Margarida, AU - Esteves,Madalena, AU - Pereira-Mendes,Joana, AU - Guimarães,Marco Rafael, AU - Almeida,Armando, AU - Leite-Almeida,Hugo, Y1 - 2019/12/10/ PY - 2019/11/10/received PY - 2019/12/06/revised PY - 2019/12/07/accepted PY - 2020/1/1/entrez PY - 2020/1/1/pubmed PY - 2020/1/1/medline KW - Decision-making KW - Delay tolerance KW - High impulsivity KW - Low impulsivity KW - Neuropathic pain KW - Variable delay-to-signal SP - 100042 EP - 100042 JF - Neurobiology of pain (Cambridge, Mass.) JO - Neurobiol Pain VL - 7 N2 - Preclinical studies on impulsive decision-making in chronic pain conditions are sparse and often contradictory. Outbred rat populations are heterogeneous regarding trait impulsivity manifestations and therefore we hypothesized that chronic pain-related alterations depend on individual traits. To test this hypothesis, we used male Wistar-Han rats in two independent experiments. Firstly, we tested the impact of spared nerve injury (SNI) in impulsive behavior evaluated by the variable delay-to-signal test (VDS). In the second experiment, SNI impact on impulsivity was again tested, but in groups previously categorized as high (HI) and low (LI) trait impulsivity in the VDS. Results showed that in an heterogenous population SNI-related impact on motor impulsivity and delay intolerance cannot be detected. However, when baseline impulsivity was considered, HI showed a significantly higher delay intolerance than the respective controls more prevalent in left-lesioned animals and appearing to result from a response correction on prematurity from VDS I to VDS II, which was present in Sham and right-lesioned animals. In conclusion, baseline differences should be more often considered when analyzing chronic pain impact. While this study pertained to impulsive behavior, other reports indicate that this can be generalized to other behavioral dimensions and that trait differences can influence not only the manifestation of comorbid behaviors but also pain itself in a complex and not totally understood manner. SN - 2452-073X UR - https://www.unboundmedicine.com/medline/citation/31890992/High_trait_impulsivity_potentiates_the_effects_of_chronic_pain_on_impulsive_behavior_ DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.