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Quantile-Specific Heritability may Account for Gene-Environment Interactions Involving Coffee Consumption.
Behav Genet. 2020 03; 50(2):119-126.BG

Abstract

Estimated heritability of coffee intake ranges from 0.36 to 0.58, however, these point estimates assume that inherited effects are the same throughout the distribution of coffee intake, i.e., whether consumption is high or low relative to intake in the population. Quantile regression of 4788 child-parent pairs and 2380 siblings showed that offspring-parent and sibling concordance became progressively greater with increasing quantiles of coffee intake. Each cup/day increase in the parents' coffee intake was associated with an offspring increase of 0.020 ± 0.013 cup/day at the 10th percentile of the offsprings' coffee intake (slope ± SE, NS), 0.137 ± 0.034 cup/day at their 25th percentile (P = 5.2 × 10-5), 0.159 ± 0.029 cup/day at the 50th percentile (P = 5.8 × 10-8), 0.233 ± 0.049 cup/day at the 75th percentile (P = 1.8 × 10-6), and 0.284 ± 0.054 cup/day at the 90th percentile (P = 1.2 × 10-7). This quantile-specific heritability suggests that factors that distinguish heavier vs. lighter drinkers (smoking, male sex) will likely manifest differences in estimated heritability, as reported.

Authors+Show Affiliations

Molecular Biophysics & Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, CA, 94720, USA. ptwilliams@lbl.gov.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31900678

Citation

Williams, Paul T.. "Quantile-Specific Heritability May Account for Gene-Environment Interactions Involving Coffee Consumption." Behavior Genetics, vol. 50, no. 2, 2020, pp. 119-126.
Williams PT. Quantile-Specific Heritability may Account for Gene-Environment Interactions Involving Coffee Consumption. Behav Genet. 2020;50(2):119-126.
Williams, P. T. (2020). Quantile-Specific Heritability may Account for Gene-Environment Interactions Involving Coffee Consumption. Behavior Genetics, 50(2), 119-126. https://doi.org/10.1007/s10519-019-09989-0
Williams PT. Quantile-Specific Heritability May Account for Gene-Environment Interactions Involving Coffee Consumption. Behav Genet. 2020;50(2):119-126. PubMed PMID: 31900678.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Quantile-Specific Heritability may Account for Gene-Environment Interactions Involving Coffee Consumption. A1 - Williams,Paul T, Y1 - 2020/01/03/ PY - 2019/04/24/received PY - 2019/12/09/accepted PY - 2020/1/5/pubmed PY - 2020/9/29/medline PY - 2020/1/5/entrez KW - Coffee KW - Gene–environment interactions KW - Heritability KW - Quantile-dependent penetrance KW - Quantile-specific heritability KW - Sex differences KW - Smoking SP - 119 EP - 126 JF - Behavior genetics JO - Behav. Genet. VL - 50 IS - 2 N2 - Estimated heritability of coffee intake ranges from 0.36 to 0.58, however, these point estimates assume that inherited effects are the same throughout the distribution of coffee intake, i.e., whether consumption is high or low relative to intake in the population. Quantile regression of 4788 child-parent pairs and 2380 siblings showed that offspring-parent and sibling concordance became progressively greater with increasing quantiles of coffee intake. Each cup/day increase in the parents' coffee intake was associated with an offspring increase of 0.020 ± 0.013 cup/day at the 10th percentile of the offsprings' coffee intake (slope ± SE, NS), 0.137 ± 0.034 cup/day at their 25th percentile (P = 5.2 × 10-5), 0.159 ± 0.029 cup/day at the 50th percentile (P = 5.8 × 10-8), 0.233 ± 0.049 cup/day at the 75th percentile (P = 1.8 × 10-6), and 0.284 ± 0.054 cup/day at the 90th percentile (P = 1.2 × 10-7). This quantile-specific heritability suggests that factors that distinguish heavier vs. lighter drinkers (smoking, male sex) will likely manifest differences in estimated heritability, as reported. SN - 1573-3297 UR - https://www.unboundmedicine.com/medline/citation/31900678/Quantile_Specific_Heritability_may_Account_for_Gene_Environment_Interactions_Involving_Coffee_Consumption_ L2 - https://doi.org/10.1007/s10519-019-09989-0 DB - PRIME DP - Unbound Medicine ER -