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Characteristics of patients with primary Sjögren's syndrome associated interstitial lung disease and relevant features of disease progression.
Clin Rheumatol. 2020 May; 39(5):1561-1568.CR

Abstract

OBJECTIVE

To investigate characteristics of patients with primary Sjögren's syndrome (pSS)-associated interstitial lung disease (ILD) and relevant features of ILD progression.

METHOD

Patients with pSS were retrospectively reviewed, and pSS-ILD and pSS non-ILD were identified. Clinical data, laboratory parameters, pulmonary high-resolution CT (HRCT), and pulmonary function tests (PFTs) were collected. pSS-ILD patients were further categorized into subgroups according to HRCT patterns or PFTs.

RESULTS

Eighty-five pSS-ILD patients and 85 pSS non-ILD patients were included. The average age at disease onset and median disease duration were significantly higher in pSS-ILD patients than those in pSS non-ILD patients (p < 0.001). Fever, xerostomia, xerophthalmia, and numbness were more frequent, and white blood cells, C reactive protein, and immunoglobulin G (IgG) levels were higher in pSS-ILD patients when compared to pSS non-ILD patients (p < 0.01). More male patients, older age at disease onset, and less frequent anti-Ro52 antibody were noted in patients with CT-usual interstitial pneumonia (UIP) pattern. In 49 patients with pSS-ILD, who repeated PFTs 6 months from the baseline, 79.6% were stable while 20.4% progressed, with ESR and CT-UIP pattern related with disease progression.

CONCLUSIONS

Patients with pSS-ILD were characterized by more frequent fever, xerophthalmia, and elevated IgG levels, while male, older age at disease onset, and less frequent anti-Ro52 antibody were related with CT-UIP pattern. ESR and CT-UIP pattern were potential predictors for ILD progression.Key Points• pSS-ILD patients are characterized by more frequent fever, xerophthalmia and elevated IgG.• Anti-Ro52 antibody is less frequent in patients with CT-UIP pattern compared to non-UIP patterns.• ESR and CT-UIP pattern are associated with pSS-ILD progression.

Authors+Show Affiliations

Division of Rheumatology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, 310005, China.Division of Rheumatology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, 310005, China. Division of Rheumatology, Ningbo No.6 Hospital, Ningbo, China.Division of Rheumatology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, 310005, China. Division of Internal Medicine, Jiaxing Maternity and Child Health Care Hospital, Jiaxing, China.Division of Rheumatology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, 310005, China.Division of Rheumatology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, 310005, China.Division of Rheumatology, The Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, 310005, China. jingxue@zju.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31902032

Citation

Zhang, Ting, et al. "Characteristics of Patients With Primary Sjögren's Syndrome Associated Interstitial Lung Disease and Relevant Features of Disease Progression." Clinical Rheumatology, vol. 39, no. 5, 2020, pp. 1561-1568.
Zhang T, Yuan F, Xu L, et al. Characteristics of patients with primary Sjögren's syndrome associated interstitial lung disease and relevant features of disease progression. Clin Rheumatol. 2020;39(5):1561-1568.
Zhang, T., Yuan, F., Xu, L., Sun, W., Liu, L., & Xue, J. (2020). Characteristics of patients with primary Sjögren's syndrome associated interstitial lung disease and relevant features of disease progression. Clinical Rheumatology, 39(5), 1561-1568. https://doi.org/10.1007/s10067-019-04906-6
Zhang T, et al. Characteristics of Patients With Primary Sjögren's Syndrome Associated Interstitial Lung Disease and Relevant Features of Disease Progression. Clin Rheumatol. 2020;39(5):1561-1568. PubMed PMID: 31902032.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristics of patients with primary Sjögren's syndrome associated interstitial lung disease and relevant features of disease progression. AU - Zhang,Ting, AU - Yuan,Fangfang, AU - Xu,Li, AU - Sun,Wenjia, AU - Liu,Lei, AU - Xue,Jing, Y1 - 2020/01/05/ PY - 2019/08/16/received PY - 2019/12/19/accepted PY - 2019/11/30/revised PY - 2020/1/7/pubmed PY - 2021/2/2/medline PY - 2020/1/6/entrez KW - Interstitial lung disease KW - Primary Sjögren’s syndrome KW - Usual interstitial pneumonia SP - 1561 EP - 1568 JF - Clinical rheumatology JO - Clin Rheumatol VL - 39 IS - 5 N2 - OBJECTIVE: To investigate characteristics of patients with primary Sjögren's syndrome (pSS)-associated interstitial lung disease (ILD) and relevant features of ILD progression. METHOD: Patients with pSS were retrospectively reviewed, and pSS-ILD and pSS non-ILD were identified. Clinical data, laboratory parameters, pulmonary high-resolution CT (HRCT), and pulmonary function tests (PFTs) were collected. pSS-ILD patients were further categorized into subgroups according to HRCT patterns or PFTs. RESULTS: Eighty-five pSS-ILD patients and 85 pSS non-ILD patients were included. The average age at disease onset and median disease duration were significantly higher in pSS-ILD patients than those in pSS non-ILD patients (p < 0.001). Fever, xerostomia, xerophthalmia, and numbness were more frequent, and white blood cells, C reactive protein, and immunoglobulin G (IgG) levels were higher in pSS-ILD patients when compared to pSS non-ILD patients (p < 0.01). More male patients, older age at disease onset, and less frequent anti-Ro52 antibody were noted in patients with CT-usual interstitial pneumonia (UIP) pattern. In 49 patients with pSS-ILD, who repeated PFTs 6 months from the baseline, 79.6% were stable while 20.4% progressed, with ESR and CT-UIP pattern related with disease progression. CONCLUSIONS: Patients with pSS-ILD were characterized by more frequent fever, xerophthalmia, and elevated IgG levels, while male, older age at disease onset, and less frequent anti-Ro52 antibody were related with CT-UIP pattern. ESR and CT-UIP pattern were potential predictors for ILD progression.Key Points• pSS-ILD patients are characterized by more frequent fever, xerophthalmia and elevated IgG.• Anti-Ro52 antibody is less frequent in patients with CT-UIP pattern compared to non-UIP patterns.• ESR and CT-UIP pattern are associated with pSS-ILD progression. SN - 1434-9949 UR - https://www.unboundmedicine.com/medline/citation/31902032/Characteristics_of_patients_with_primary_Sj��gren's_syndrome_associated_interstitial_lung_disease_and_relevant_features_of_disease_progression_ L2 - https://dx.doi.org/10.1007/s10067-019-04906-6 DB - PRIME DP - Unbound Medicine ER -