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Self-assembled Angelica sinensis polysaccharide nanoparticles with an instinctive liver-targeting ability as a drug carrier for acute alcoholic liver damage protection.
Int J Pharm. 2020 Mar 15; 577:118996.IJ

Abstract

The present work aimed to study the feasibility of Angelica sinensis polysaccharide (ASP) as an instinctive liver-targeting drug delivery carrier with applications in acute alcoholic liver damage (ALD). Amphipathic cholesteryl hemisuccinate-ASP (ASP-CHEMS) conjugate was synthesized by an esterification reaction and characterized by conventional methods. ASP-CHEMS self-assembled nanoparticles (ACNPs) and Curcumin-loaded ACNPs (Cur/ACNPs) were fabricated with a roughly spherical shape, and their sizes were ranged from 200 to 260 nm in aqueous solution. Compared with free Cur, Cur/ACNPs displayed enhanced solubility, good photostability, and a sustained release of Cur over 72 h. In the in vivo cellular uptake behavior study and in vivo bioimaging experiments, the ACNPs showed excellent liver-targeting capability because of the specific recognition by the asialoglycoprotein receptor (ASGPR) overexpressed on the hepatocyte membrane. The tissue distribution of Cur/ACNPs in mice further demonstrated that ACNPs could distinctly enhance the distribution of Cur into the liver. Furthermore, Cur/ACNPs protected the liver from acute ALD by attenuating oxidative stress and were superior to the protective effects of free Cur and the Cur-loaded CHEMS modified-dextran derivative. According to the results, ACNPs may serve as a promising liver-targeting drug delivery carrier for liver disease prevention.

Authors+Show Affiliations

Hubei Key Laboratory of Nature Medicinal Chemistry and Resource Evaluation, Tongji Medical College of Pharmacy, Huazhong University of Science and Technology, Wuhan, China.Hubei Key Laboratory of Nature Medicinal Chemistry and Resource Evaluation, Tongji Medical College of Pharmacy, Huazhong University of Science and Technology, Wuhan, China.Hubei Key Laboratory of Nature Medicinal Chemistry and Resource Evaluation, Tongji Medical College of Pharmacy, Huazhong University of Science and Technology, Wuhan, China.Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: zhangwkp@163.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31904402

Citation

Wang, Kaiping, et al. "Self-assembled Angelica Sinensis Polysaccharide Nanoparticles With an Instinctive Liver-targeting Ability as a Drug Carrier for Acute Alcoholic Liver Damage Protection." International Journal of Pharmaceutics, vol. 577, 2020, p. 118996.
Wang K, Xu J, Liu Y, et al. Self-assembled Angelica sinensis polysaccharide nanoparticles with an instinctive liver-targeting ability as a drug carrier for acute alcoholic liver damage protection. Int J Pharm. 2020;577:118996.
Wang, K., Xu, J., Liu, Y., Cui, Z., He, Z., Zheng, Z., Huang, X., & Zhang, Y. (2020). Self-assembled Angelica sinensis polysaccharide nanoparticles with an instinctive liver-targeting ability as a drug carrier for acute alcoholic liver damage protection. International Journal of Pharmaceutics, 577, 118996. https://doi.org/10.1016/j.ijpharm.2019.118996
Wang K, et al. Self-assembled Angelica Sinensis Polysaccharide Nanoparticles With an Instinctive Liver-targeting Ability as a Drug Carrier for Acute Alcoholic Liver Damage Protection. Int J Pharm. 2020 Mar 15;577:118996. PubMed PMID: 31904402.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Self-assembled Angelica sinensis polysaccharide nanoparticles with an instinctive liver-targeting ability as a drug carrier for acute alcoholic liver damage protection. AU - Wang,Kaiping, AU - Xu,Jingya, AU - Liu,Yan, AU - Cui,Zheng, AU - He,Zihao, AU - Zheng,Ziming, AU - Huang,Xiao, AU - Zhang,Yu, Y1 - 2020/01/03/ PY - 2019/07/29/received PY - 2019/12/07/revised PY - 2019/12/23/accepted PY - 2020/1/7/pubmed PY - 2021/1/6/medline PY - 2020/1/7/entrez KW - Angelica sinensis polysaccharide KW - Liver protection KW - Liver targeting KW - Self-assembled nanoparticles SP - 118996 EP - 118996 JF - International journal of pharmaceutics JO - Int J Pharm VL - 577 N2 - The present work aimed to study the feasibility of Angelica sinensis polysaccharide (ASP) as an instinctive liver-targeting drug delivery carrier with applications in acute alcoholic liver damage (ALD). Amphipathic cholesteryl hemisuccinate-ASP (ASP-CHEMS) conjugate was synthesized by an esterification reaction and characterized by conventional methods. ASP-CHEMS self-assembled nanoparticles (ACNPs) and Curcumin-loaded ACNPs (Cur/ACNPs) were fabricated with a roughly spherical shape, and their sizes were ranged from 200 to 260 nm in aqueous solution. Compared with free Cur, Cur/ACNPs displayed enhanced solubility, good photostability, and a sustained release of Cur over 72 h. In the in vivo cellular uptake behavior study and in vivo bioimaging experiments, the ACNPs showed excellent liver-targeting capability because of the specific recognition by the asialoglycoprotein receptor (ASGPR) overexpressed on the hepatocyte membrane. The tissue distribution of Cur/ACNPs in mice further demonstrated that ACNPs could distinctly enhance the distribution of Cur into the liver. Furthermore, Cur/ACNPs protected the liver from acute ALD by attenuating oxidative stress and were superior to the protective effects of free Cur and the Cur-loaded CHEMS modified-dextran derivative. According to the results, ACNPs may serve as a promising liver-targeting drug delivery carrier for liver disease prevention. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/31904402/Self-assembled_Angelica_sinensis_polysaccharide_nanoparticles_with_an_instinctive_liver-targeting_ability_as_a_drug_carrier_for_acute_alcoholic_liver_damage_protection. L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(19)31057-9 DB - PRIME DP - Unbound Medicine ER -