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Impact of air pollution on intestinal redox lipidome and microbiome.
Free Radic Biol Med. 2020 05 01; 151:99-110.FR

Abstract

Air pollution is a rising public health issue worldwide. Cumulative epidemiological and experimental studies have shown that exposure to air pollution such as particulate matter (PM) is linked with increased hospital admissions and all-cause mortality. While previous studies on air pollution mostly focused on the respiratory and cardiovascular effects, emerging evidence supports a significant impact of air pollution on the gastrointestinal (GI) system. The gut is exposed to PM as most of the inhaled particles are removed from the lungs to the GI tract via mucociliary clearance. Ingestion of contaminated food and water is another common source of GI tract exposure to pollutants. Recent studies have associated air pollution with intestinal diseases, including appendicitis, colorectal cancer, and inflammatory bowel disease. In addition to the liver and adipose tissue, intestine is an important organ system for lipid metabolism, and the intestinal redox lipids might be tightly associated with the intestinal and systematic inflammation. The gut microbiota modulates lipid metabolism and contributes to the initiation and development of intestinal disease including inflammatory bowel disease. Recent data support microbiome implication in air pollution-mediated intestinal and systematic effects. In this review, the associations between air pollution and intestinal diseases, and the alterations of intestinal lipidome and gut microbiome by air pollution are highlighted. The potential mechanistic aspects underlying air pollution-mediated intestinal pathology will also be discussed.

Authors+Show Affiliations

College of Health Science and Environmental Engineering, Shenzhen Technology University, Shenzhen, Guangdong, China.Department of Medicine, University of California, Los Angeles, CA, USA.Department of Medicine, University of California, Los Angeles, CA, USA; Department of Bioengineering, University of California, Los Angeles, CA, USA; West Los Angeles Healthcare System, USA; Medical Engineering, California Institute of Technology, Pasadena, CA, USA.College of Health Science and Environmental Engineering, Shenzhen Technology University, Shenzhen, Guangdong, China. Electronic address: lirongsong@sztu.edu.cn.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

31904545

Citation

Feng, Juan, et al. "Impact of Air Pollution On Intestinal Redox Lipidome and Microbiome." Free Radical Biology & Medicine, vol. 151, 2020, pp. 99-110.
Feng J, Cavallero S, Hsiai T, et al. Impact of air pollution on intestinal redox lipidome and microbiome. Free Radic Biol Med. 2020;151:99-110.
Feng, J., Cavallero, S., Hsiai, T., & Li, R. (2020). Impact of air pollution on intestinal redox lipidome and microbiome. Free Radical Biology & Medicine, 151, 99-110. https://doi.org/10.1016/j.freeradbiomed.2019.12.044
Feng J, et al. Impact of Air Pollution On Intestinal Redox Lipidome and Microbiome. Free Radic Biol Med. 2020 05 1;151:99-110. PubMed PMID: 31904545.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of air pollution on intestinal redox lipidome and microbiome. AU - Feng,Juan, AU - Cavallero,Susana, AU - Hsiai,Tzung, AU - Li,Rongsong, Y1 - 2020/01/02/ PY - 2019/11/13/received PY - 2019/12/29/revised PY - 2019/12/30/accepted PY - 2020/1/7/pubmed PY - 2020/1/7/medline PY - 2020/1/7/entrez KW - Air pollution KW - Intestinal microbiome KW - Intestinal redox lipidome SP - 99 EP - 110 JF - Free radical biology & medicine JO - Free Radic Biol Med VL - 151 N2 - Air pollution is a rising public health issue worldwide. Cumulative epidemiological and experimental studies have shown that exposure to air pollution such as particulate matter (PM) is linked with increased hospital admissions and all-cause mortality. While previous studies on air pollution mostly focused on the respiratory and cardiovascular effects, emerging evidence supports a significant impact of air pollution on the gastrointestinal (GI) system. The gut is exposed to PM as most of the inhaled particles are removed from the lungs to the GI tract via mucociliary clearance. Ingestion of contaminated food and water is another common source of GI tract exposure to pollutants. Recent studies have associated air pollution with intestinal diseases, including appendicitis, colorectal cancer, and inflammatory bowel disease. In addition to the liver and adipose tissue, intestine is an important organ system for lipid metabolism, and the intestinal redox lipids might be tightly associated with the intestinal and systematic inflammation. The gut microbiota modulates lipid metabolism and contributes to the initiation and development of intestinal disease including inflammatory bowel disease. Recent data support microbiome implication in air pollution-mediated intestinal and systematic effects. In this review, the associations between air pollution and intestinal diseases, and the alterations of intestinal lipidome and gut microbiome by air pollution are highlighted. The potential mechanistic aspects underlying air pollution-mediated intestinal pathology will also be discussed. SN - 1873-4596 UR - https://www.unboundmedicine.com/medline/citation/31904545/Impact_of_air_pollution_on_intestinal_redox_lipidome_and_microbiome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0891-5849(19)32274-9 DB - PRIME DP - Unbound Medicine ER -