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Effects of acute cannabidiol administration on anxiety and tremors induced by a Simulated Public Speaking Test in patients with Parkinson's disease.
J Psychopharmacol. 2020 02; 34(2):189-196.JP

Abstract

BACKGROUND

Cannabidiol (CBD) is one of the main components of Cannabis sativa and has anxiolytic properties, but no study has been conducted to evaluate the effects of CBD on anxiety signs and symptoms in patients with Parkinson's disease (PD). This study aimed to evaluate the impacts of acute CBD administration at a dose of 300 mg on anxiety measures and tremors induced by a Simulated Public Speaking Test (SPST) in individuals with PD.

METHODS

A randomised, double-blinded, placebo-controlled, crossover clinical trial was conducted. A total of 24 individuals with PD were included and underwent two experimental sessions within a 15-day interval. After taking CBD or a placebo, participants underwent the SPST. During the test, the following data were collected: heart rate, systemic blood pressure and tremor frequency and amplitude. In addition, the Visual Analog Mood Scales (VAMS) and Self-Statements during Public Speaking Scale were applied. Statistical analysis was performed by repeated-measures analysis of variance (ANOVA) while considering the drug, SPST phase and interactions between these variables.

RESULTS

There were statistically significant differences in the VAMS anxiety factor for the drug; CBD attenuated the anxiety experimentally induced by the SPST. Repeated-measures ANOVA showed significant differences in the drug for the variable related to tremor amplitude as recorded by the accelerometer.

CONCLUSION

Acute CBD administration at a dose of 300 mg decreased anxiety in patients with PD, and there was also decreased tremor amplitude in an anxiogenic situation.

Authors+Show Affiliations

Department of Gerontology, Federal University of São Carlos, São Carlos, Brazil.Department of Psychology, Federal University of São Carlos, São Carlos, Brazil.Department of Neuroscience and Behavior, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.Department of Gerontology, Federal University of São Carlos, São Carlos, Brazil.Institute of Mathematical and Computer Sciences, University of São Paulo, São Carlos, Brazil.Department of Neuroscience and Behavior, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.Department of Neuroscience and Behavior, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.Department of Neuroscience and Behavior, Faculty of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil.Department of Gerontology, Federal University of São Carlos, São Carlos, Brazil.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31909680

Citation

de Faria, Stephanie Martins, et al. "Effects of Acute Cannabidiol Administration On Anxiety and Tremors Induced By a Simulated Public Speaking Test in Patients With Parkinson's Disease." Journal of Psychopharmacology (Oxford, England), vol. 34, no. 2, 2020, pp. 189-196.
de Faria SM, de Morais Fabrício D, Tumas V, et al. Effects of acute cannabidiol administration on anxiety and tremors induced by a Simulated Public Speaking Test in patients with Parkinson's disease. J Psychopharmacol. 2020;34(2):189-196.
de Faria, S. M., de Morais Fabrício, D., Tumas, V., Castro, P. C., Ponti, M. A., Hallak, J. E., Zuardi, A. W., Crippa, J. A. S., & Chagas, M. H. N. (2020). Effects of acute cannabidiol administration on anxiety and tremors induced by a Simulated Public Speaking Test in patients with Parkinson's disease. Journal of Psychopharmacology (Oxford, England), 34(2), 189-196. https://doi.org/10.1177/0269881119895536
de Faria SM, et al. Effects of Acute Cannabidiol Administration On Anxiety and Tremors Induced By a Simulated Public Speaking Test in Patients With Parkinson's Disease. J Psychopharmacol. 2020;34(2):189-196. PubMed PMID: 31909680.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of acute cannabidiol administration on anxiety and tremors induced by a Simulated Public Speaking Test in patients with Parkinson's disease. AU - de Faria,Stephanie Martins, AU - de Morais Fabrício,Daiene, AU - Tumas,Vitor, AU - Castro,Paula Costa, AU - Ponti,Moacir Antonelli, AU - Hallak,Jaime Ec, AU - Zuardi,Antonio W, AU - Crippa,José Alexandre S, AU - Chagas,Marcos Hortes Nisihara, Y1 - 2020/01/07/ PY - 2020/1/8/pubmed PY - 2021/1/12/medline PY - 2020/1/8/entrez KW - Cannabidiol KW - Parkinson’s disease KW - anxiety KW - tremor SP - 189 EP - 196 JF - Journal of psychopharmacology (Oxford, England) JO - J Psychopharmacol VL - 34 IS - 2 N2 - BACKGROUND: Cannabidiol (CBD) is one of the main components of Cannabis sativa and has anxiolytic properties, but no study has been conducted to evaluate the effects of CBD on anxiety signs and symptoms in patients with Parkinson's disease (PD). This study aimed to evaluate the impacts of acute CBD administration at a dose of 300 mg on anxiety measures and tremors induced by a Simulated Public Speaking Test (SPST) in individuals with PD. METHODS: A randomised, double-blinded, placebo-controlled, crossover clinical trial was conducted. A total of 24 individuals with PD were included and underwent two experimental sessions within a 15-day interval. After taking CBD or a placebo, participants underwent the SPST. During the test, the following data were collected: heart rate, systemic blood pressure and tremor frequency and amplitude. In addition, the Visual Analog Mood Scales (VAMS) and Self-Statements during Public Speaking Scale were applied. Statistical analysis was performed by repeated-measures analysis of variance (ANOVA) while considering the drug, SPST phase and interactions between these variables. RESULTS: There were statistically significant differences in the VAMS anxiety factor for the drug; CBD attenuated the anxiety experimentally induced by the SPST. Repeated-measures ANOVA showed significant differences in the drug for the variable related to tremor amplitude as recorded by the accelerometer. CONCLUSION: Acute CBD administration at a dose of 300 mg decreased anxiety in patients with PD, and there was also decreased tremor amplitude in an anxiogenic situation. SN - 1461-7285 UR - https://www.unboundmedicine.com/medline/citation/31909680/Effects_of_acute_cannabidiol_administration_on_anxiety_and_tremors_induced_by_a_Simulated_Public_Speaking_Test_in_patients_with_Parkinson's_disease_ L2 - https://journals.sagepub.com/doi/10.1177/0269881119895536?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -