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Association between ApoE Polymorphism and Type 2 Diabetes: A Meta-Analysis of 59 Studies.
Biomed Environ Sci. 2019 Nov; 32(11):823-838.BE

Abstract

OBJECTIVE

To identify the important risk factors for type 2 Diabetes Mellitus (T2DM) and develop effective strategies to address the problem of T2DM. Our study aimed to evaluate the association between apolipoprotein E (ApoE) genetic polymorphism and type 2 diabetes, and to provide clues for the etiology of T2DM.

METHODS

Based on the criteria of inclusion and exclusion, we extracted, pooled, analyzed and assessed the case-control studies of ApoE polymorphism and T2DM published in PubMed, Web of Science, Medline, WanFang, VIP, and CNKI databases by R soft-ware (version 3.4.3). We used Random-effect models when heterogeneity was present in between-study, and fixed-effect models otherwise.

RESULTS

We had 59 studies covering 6,872 cases with T2DM and 8,250 controls, and compared the alleles and genotypes of ApoE between cases and controls. When we conducted a comparison between ApoE ε4 and ε3 alleles, we produced a pooled OR of 1.18 (95% CI: 1.09-1.28; P < 0.001). ApoE ε2/ε2 genotype displayed a possible association with T2DM (OR = 1.46; 95% CI: 1.11-1.93; P = 0.007), ε3/ε4 genotype showed a 1.11-fold risk (OR = 1.11; 95% CI: 1.01-1.22; P = 0.039) and ε4/ε4 genotype had a 1.71-fold risk of developing T2DM (OR = 1.71; 95% CI: 1.33-2.19; P < 0.001) when they were compared with ε3/ε3 genotype.

CONCLUSION

There is an association between ApoE polymorphism and T2DM: allele ε4 and genotypes (ε2/ε2, ε3/ε4, and ε4/ε4) are associated with the increased risk for the development of T2DM, and they may be risk factors for T2DM.

Authors+Show Affiliations

Department of Radiation Protection, School of Public Health, Jilin University, Changchun 130021, Jilin, China.Department of Epidemiology and Statistics, School of Public Health, Jilin University, Changchun 130021, Jilin, China.Department of Ophthalmology, China-Japan Union Hospital, Jilin University, Changchun 130033 Jilin, China.Function Experiment Center of College of Basic Medicine, Jilin University, Changchun 130021, Jilin, China.Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun 130021, Jilin, China.

Pub Type(s)

Journal Article
Meta-Analysis

Language

eng

PubMed ID

31910940

Citation

Chen, Da Wei, et al. "Association Between ApoE Polymorphism and Type 2 Diabetes: a Meta-Analysis of 59 Studies." Biomedical and Environmental Sciences : BES, vol. 32, no. 11, 2019, pp. 823-838.
Chen DW, Shi JK, Li Y, et al. Association between ApoE Polymorphism and Type 2 Diabetes: A Meta-Analysis of 59 Studies. Biomed Environ Sci. 2019;32(11):823-838.
Chen, D. W., Shi, J. K., Li, Y., Yang, Y., & Ren, S. P. (2019). Association between ApoE Polymorphism and Type 2 Diabetes: A Meta-Analysis of 59 Studies. Biomedical and Environmental Sciences : BES, 32(11), 823-838. https://doi.org/10.3967/bes2019.104
Chen DW, et al. Association Between ApoE Polymorphism and Type 2 Diabetes: a Meta-Analysis of 59 Studies. Biomed Environ Sci. 2019;32(11):823-838. PubMed PMID: 31910940.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between ApoE Polymorphism and Type 2 Diabetes: A Meta-Analysis of 59 Studies. AU - Chen,Da Wei, AU - Shi,Ji Kang, AU - Li,Yun, AU - Yang,Yu, AU - Ren,Shu Ping, PY - 2019/05/31/received PY - 2019/09/17/accepted PY - 2020/1/9/entrez PY - 2020/1/9/pubmed PY - 2020/5/20/medline KW - Apolipoprotein E KW - Meta-analysis KW - Polymorphism KW - Type 2 diabetes SP - 823 EP - 838 JF - Biomedical and environmental sciences : BES JO - Biomed Environ Sci VL - 32 IS - 11 N2 - OBJECTIVE: To identify the important risk factors for type 2 Diabetes Mellitus (T2DM) and develop effective strategies to address the problem of T2DM. Our study aimed to evaluate the association between apolipoprotein E (ApoE) genetic polymorphism and type 2 diabetes, and to provide clues for the etiology of T2DM. METHODS: Based on the criteria of inclusion and exclusion, we extracted, pooled, analyzed and assessed the case-control studies of ApoE polymorphism and T2DM published in PubMed, Web of Science, Medline, WanFang, VIP, and CNKI databases by R soft-ware (version 3.4.3). We used Random-effect models when heterogeneity was present in between-study, and fixed-effect models otherwise. RESULTS: We had 59 studies covering 6,872 cases with T2DM and 8,250 controls, and compared the alleles and genotypes of ApoE between cases and controls. When we conducted a comparison between ApoE ε4 and ε3 alleles, we produced a pooled OR of 1.18 (95% CI: 1.09-1.28; P < 0.001). ApoE ε2/ε2 genotype displayed a possible association with T2DM (OR = 1.46; 95% CI: 1.11-1.93; P = 0.007), ε3/ε4 genotype showed a 1.11-fold risk (OR = 1.11; 95% CI: 1.01-1.22; P = 0.039) and ε4/ε4 genotype had a 1.71-fold risk of developing T2DM (OR = 1.71; 95% CI: 1.33-2.19; P < 0.001) when they were compared with ε3/ε3 genotype. CONCLUSION: There is an association between ApoE polymorphism and T2DM: allele ε4 and genotypes (ε2/ε2, ε3/ε4, and ε4/ε4) are associated with the increased risk for the development of T2DM, and they may be risk factors for T2DM. SN - 2214-0190 UR - https://www.unboundmedicine.com/medline/citation/31910940/Association_between_ApoE_Polymorphism_and_Type_2_Diabetes:_A_Meta_Analysis_of_59_Studies_ L2 - https://doi.org/10.3967/bes2019.104 DB - PRIME DP - Unbound Medicine ER -