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Calcific Aortic Valve Stenosis and Atherosclerotic Calcification.
Curr Atheroscler Rep. 2020 01 07; 22(2):2.CA

Abstract

PURPOSE OF REVIEW

This review summarizes the pathophysiology of calcific aortic valve stenosis (CAVS) and surveys relevant clinical data and basic research that explain how CAVS arises.

RECENT FINDINGS

Lipoprotein(a) [Lp(a)], lipoprotein-associated phospholipase A2 (Lp-PLA2), oxidized phospholipids (OxPL), autotaxin, and genetic driving forces such as mutations in LPA gene and NOTCH gene seem to play a major role in the development of CAVS. These factors might well become targets of medical therapy in the coming years. CVAS seems to be a multifactorial disease that has much in common with coronary artery disease, mainly regarding lipidic accumulation and calcium deposition. No clinical trials conducted to date have managed to answer the key question of whether Lp(a) lowering and anti-calcific therapies confer a benefit in terms of reducing incidence or progression of CAVS, although additional outcome trials are ongoing.

Authors+Show Affiliations

Division of Cardiovascular Surgery of Pronto Socorro Cardiológico de Pernambuco, PROCAPE, Av. Eng. Domingos Ferreira n°4172. Edf. Paquetá, apt° 405, Recife, Pernambuco, 51021-040, Brazil. michel_pompeu@yahoo.com.br. University of Pernambuco, UPE, Recife, Brazil. michel_pompeu@yahoo.com.br. Nucleus of Postgraduate and Research in Health Sciences of Faculty of Medical Sciences and Biological Sciences Instituite, FCM/ICB, Recife, Brazil. michel_pompeu@yahoo.com.br.Division of Cardiovascular Surgery of Pronto Socorro Cardiológico de Pernambuco, PROCAPE, Av. Eng. Domingos Ferreira n°4172. Edf. Paquetá, apt° 405, Recife, Pernambuco, 51021-040, Brazil. University of Pernambuco, UPE, Recife, Brazil.Division of Cardiovascular Surgery of Pronto Socorro Cardiológico de Pernambuco, PROCAPE, Av. Eng. Domingos Ferreira n°4172. Edf. Paquetá, apt° 405, Recife, Pernambuco, 51021-040, Brazil. University of Pernambuco, UPE, Recife, Brazil.Division of Cardiovascular Surgery of Pronto Socorro Cardiológico de Pernambuco, PROCAPE, Av. Eng. Domingos Ferreira n°4172. Edf. Paquetá, apt° 405, Recife, Pernambuco, 51021-040, Brazil. University of Pernambuco, UPE, Recife, Brazil. Nucleus of Postgraduate and Research in Health Sciences of Faculty of Medical Sciences and Biological Sciences Instituite, FCM/ICB, Recife, Brazil.Québec Heart and Lung Institute/Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, 2725 Chemin Sainte Foy, #A-2075, Quebec, QC, G1V4G5, Canada.Québec Heart and Lung Institute/Institut Universitaire de Cardiologie et de Pneumologie de Québec, Université Laval, 2725 Chemin Sainte Foy, #A-2075, Quebec, QC, G1V4G5, Canada.Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy. Mediterranea Cardiocentro, Naples, Italy.Department of Thoracic and Cardiovascular Surgery, West German Heart and Vascular Center Essen, University Hospital of Essen, University Duisburg-Essen, Essen, Germany.Department of Thoracic and Cardiovascular Surgery, West German Heart and Vascular Center Essen, University Hospital of Essen, University Duisburg-Essen, Essen, Germany.Department of Thoracic and Cardiovascular Surgery, West German Heart and Vascular Center Essen, University Hospital of Essen, University Duisburg-Essen, Essen, Germany.Division of Cardiovascular Surgery of Pronto Socorro Cardiológico de Pernambuco, PROCAPE, Av. Eng. Domingos Ferreira n°4172. Edf. Paquetá, apt° 405, Recife, Pernambuco, 51021-040, Brazil. University of Pernambuco, UPE, Recife, Brazil. Nucleus of Postgraduate and Research in Health Sciences of Faculty of Medical Sciences and Biological Sciences Instituite, FCM/ICB, Recife, Brazil.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31912380

Citation

de Oliveira Sá, Michel Pompeu Barros, et al. "Calcific Aortic Valve Stenosis and Atherosclerotic Calcification." Current Atherosclerosis Reports, vol. 22, no. 2, 2020, p. 2.
de Oliveira Sá MPB, Cavalcanti LRP, Perazzo ÁM, et al. Calcific Aortic Valve Stenosis and Atherosclerotic Calcification. Curr Atheroscler Rep. 2020;22(2):2.
de Oliveira Sá, M. P. B., Cavalcanti, L. R. P., Perazzo, Á. M., Gomes, R. A. F., Clavel, M. A., Pibarot, P., Biondi-Zoccai, G., Zhigalov, K., Weymann, A., Ruhparwar, A., & Lima, R. C. (2020). Calcific Aortic Valve Stenosis and Atherosclerotic Calcification. Current Atherosclerosis Reports, 22(2), 2. https://doi.org/10.1007/s11883-020-0821-7
de Oliveira Sá MPB, et al. Calcific Aortic Valve Stenosis and Atherosclerotic Calcification. Curr Atheroscler Rep. 2020 01 7;22(2):2. PubMed PMID: 31912380.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Calcific Aortic Valve Stenosis and Atherosclerotic Calcification. AU - de Oliveira Sá,Michel Pompeu Barros, AU - Cavalcanti,Luiz Rafael P, AU - Perazzo,Álvaro M, AU - Gomes,Rafael A F, AU - Clavel,Marie-Annick, AU - Pibarot,Philippe, AU - Biondi-Zoccai,Giuseppe, AU - Zhigalov,Konstantin, AU - Weymann,Alexander, AU - Ruhparwar,Arjang, AU - Lima,Ricardo Carvalho, Y1 - 2020/01/07/ PY - 2020/1/9/entrez PY - 2020/1/9/pubmed PY - 2020/10/21/medline KW - Aortic valve stenosis KW - Atherosclerosis KW - Calcific aortic stenosis KW - Vascular calcification SP - 2 EP - 2 JF - Current atherosclerosis reports JO - Curr Atheroscler Rep VL - 22 IS - 2 N2 - PURPOSE OF REVIEW: This review summarizes the pathophysiology of calcific aortic valve stenosis (CAVS) and surveys relevant clinical data and basic research that explain how CAVS arises. RECENT FINDINGS: Lipoprotein(a) [Lp(a)], lipoprotein-associated phospholipase A2 (Lp-PLA2), oxidized phospholipids (OxPL), autotaxin, and genetic driving forces such as mutations in LPA gene and NOTCH gene seem to play a major role in the development of CAVS. These factors might well become targets of medical therapy in the coming years. CVAS seems to be a multifactorial disease that has much in common with coronary artery disease, mainly regarding lipidic accumulation and calcium deposition. No clinical trials conducted to date have managed to answer the key question of whether Lp(a) lowering and anti-calcific therapies confer a benefit in terms of reducing incidence or progression of CAVS, although additional outcome trials are ongoing. SN - 1534-6242 UR - https://www.unboundmedicine.com/medline/citation/31912380/Calcific_Aortic_Valve_Stenosis_and_Atherosclerotic_Calcification_ L2 - https://dx.doi.org/10.1007/s11883-020-0821-7 DB - PRIME DP - Unbound Medicine ER -