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Preparation of Restricted Access Media-Molecularly Imprinted Polymers for the Detection of Chloramphenicol in Bovine Serum.
J Anal Methods Chem. 2019; 2019:7930102.JA

Abstract

Chloramphenicol- (CAP-) restricted access media-molecularly imprinted polymers (CAP-RAM-MIPs) were prepared by precipitation polymerization using CAP as a template molecule, 2-diethylaminoethyl methacrylate (DEAEM) as a functional monomer, ethylene glycol dimethyl acrylate (EDMA) as a crosslinking agent, glycidyl methacrylate (GMA) as an outer hydrophilic functional monomer, and acetonitrile as a pore former and solvent. The CAP-RAM-MIPs were successfully characterized by Fourier-transform infrared spectroscopy, scanning electron microscopy, and thermogravimetric analysis. The adsorption performance was investigated in detail using static, dynamic, and selective adsorption experiments. Adsorption equilibrium could be reached within 11 min. The CAP-RAM-MIPs had a high adsorption rate and good specific adsorption properties. Scatchard fitting curves indicated there were two binding sites for CAP-RAM-MIPs. Adsorption was Freundlich multilayer adsorption and consistent with the quasi-second kinetic model. Using CAP-RAM-MIPs for selective separation and enrichment CAP in bovine serum in combination with high-performance liquid chromatography (HPLC), CAP recovery ranged from 94.1 to 97.9% with relative standard deviations of 0.7-1.5%. This material has broad application prospects in enrichment and separation.

Authors+Show Affiliations

College of Chemistry and Chemical Engineering, North Minzu University, Yinchuan 750021, China.College of Chemistry and Chemical Engineering, North Minzu University, Yinchuan 750021, China. China Customs Ningxia Entry-Exit Inspection and Quarantine, Yinchuan 750000, China.College of Chemistry and Chemical Engineering, North Minzu University, Yinchuan 750021, China.College of Chemistry and Chemical Engineering, North Minzu University, Yinchuan 750021, China.College of Chemistry and Chemical Engineering, North Minzu University, Yinchuan 750021, China.College of Chemistry and Chemical Engineering, North Minzu University, Yinchuan 750021, China.College of Chemistry and Chemical Engineering, North Minzu University, Yinchuan 750021, China.College of Chemistry and Chemical Engineering, North Minzu University, Yinchuan 750021, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31915565

Citation

Zhao, Shanwen, et al. "Preparation of Restricted Access Media-Molecularly Imprinted Polymers for the Detection of Chloramphenicol in Bovine Serum." Journal of Analytical Methods in Chemistry, vol. 2019, 2019, p. 7930102.
Zhao S, Wei C, Sun Z, et al. Preparation of Restricted Access Media-Molecularly Imprinted Polymers for the Detection of Chloramphenicol in Bovine Serum. J Anal Methods Chem. 2019;2019:7930102.
Zhao, S., Wei, C., Sun, Z., Liu, H., Zhou, Y., Wang, X., Li, J., & Gong, B. (2019). Preparation of Restricted Access Media-Molecularly Imprinted Polymers for the Detection of Chloramphenicol in Bovine Serum. Journal of Analytical Methods in Chemistry, 2019, 7930102. https://doi.org/10.1155/2019/7930102
Zhao S, et al. Preparation of Restricted Access Media-Molecularly Imprinted Polymers for the Detection of Chloramphenicol in Bovine Serum. J Anal Methods Chem. 2019;2019:7930102. PubMed PMID: 31915565.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation of Restricted Access Media-Molecularly Imprinted Polymers for the Detection of Chloramphenicol in Bovine Serum. AU - Zhao,Shanwen, AU - Wei,Chanling, AU - Sun,Zhian, AU - Liu,Huachun, AU - Zhou,Yanqiang, AU - Wang,Xiaoxiao, AU - Li,Jianmin, AU - Gong,Bolin, Y1 - 2019/12/12/ PY - 2019/05/15/received PY - 2019/11/25/accepted PY - 2020/1/10/entrez PY - 2020/1/10/pubmed PY - 2020/1/10/medline SP - 7930102 EP - 7930102 JF - Journal of analytical methods in chemistry JO - J Anal Methods Chem VL - 2019 N2 - Chloramphenicol- (CAP-) restricted access media-molecularly imprinted polymers (CAP-RAM-MIPs) were prepared by precipitation polymerization using CAP as a template molecule, 2-diethylaminoethyl methacrylate (DEAEM) as a functional monomer, ethylene glycol dimethyl acrylate (EDMA) as a crosslinking agent, glycidyl methacrylate (GMA) as an outer hydrophilic functional monomer, and acetonitrile as a pore former and solvent. The CAP-RAM-MIPs were successfully characterized by Fourier-transform infrared spectroscopy, scanning electron microscopy, and thermogravimetric analysis. The adsorption performance was investigated in detail using static, dynamic, and selective adsorption experiments. Adsorption equilibrium could be reached within 11 min. The CAP-RAM-MIPs had a high adsorption rate and good specific adsorption properties. Scatchard fitting curves indicated there were two binding sites for CAP-RAM-MIPs. Adsorption was Freundlich multilayer adsorption and consistent with the quasi-second kinetic model. Using CAP-RAM-MIPs for selective separation and enrichment CAP in bovine serum in combination with high-performance liquid chromatography (HPLC), CAP recovery ranged from 94.1 to 97.9% with relative standard deviations of 0.7-1.5%. This material has broad application prospects in enrichment and separation. SN - 2090-8865 UR - https://www.unboundmedicine.com/medline/citation/31915565/Preparation_of_Restricted_Access_Media-Molecularly_Imprinted_Polymers_for_the_Detection_of_Chloramphenicol_in_Bovine_Serum L2 - https://dx.doi.org/10.1155/2019/7930102 DB - PRIME DP - Unbound Medicine ER -
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