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Exposure to dietary polychlorinated biphenyls and dioxins, and its relationship with subclinical coronary atherosclerosis: The Aragon Workers' Health Study.
Environ Int. 2020 03; 136:105433.EI

Abstract

BACKGROUND

Experimental evidence has revealed that exposure to polychlorinated biphenyls (PCBs) and dioxins directly impairs endothelial function and induces atherosclerosis progression. In the general population, despite a small number of recent studies finding a link between PCBs, and stroke and myocardial infraction, the association with early coronary atherosclerosis has not been examined yet.

OBJECTIVE

To examine whether dietary exposure to PCBs and dioxins is associated with subclinical coronary atherosclerosis in a middle-aged men.

DESIGN

Cross-sectional analysis comprising 1844 men in their 50 s and free of cardiovascular disease, who participated in the Aragon Workers' Health Study (AWHS). Individual dietary exposures to PCBs and dioxins were estimated by the contaminant's concentration in food coupled with the corresponding consumption and then participants were classified into quartiles of consumption. Coronary artery calcium score (CACS) was assessed by computerized tomography. We conducted ordered logistic regressions to estimate the odds ratio (OR) and 95% confidence intervals (CIs) for progression to the categories of more coronary artery calcium, adjusting for potential confounders.

RESULTS

Among the participants, coronary calcium was not shown in 60.1% (n = 1108), 29.8% had a CACS > 0 and <100 (n = 550), and the remaining 10.1% (n = 186) had a CACS ≥ 100. Compared with those in the first quartile of PCBs exposure, those in the fourth one had an increased odds for having coronary calcium (OR 2.02, 95% CI [1.18, 3.47], p trend 0.019) and for having progressed to categories of more intense calcification (OR 2.03, 95% CI [1.21, 3.40], p trend 0.012). However, no association was found between dietary dioxins exposure and prevalent coronary artery calcium.

CONCLUSIONS

In this general male population, dietary exposure to PCBs, but not to dioxins, was associated with a higher prevalence of coronary calcium and to more intense subclinical coronary atherosclerosis. PCBs exposure seems to increase the risk of coronary disease in men from the very early stages.

Authors+Show Affiliations

Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid, CEI UAM+CSIC, Madrid, Spain; Unit of Nutritional and Cardiovascular Epidemiology, Environmental Medicine Institute (IMM), Karolinska Institutet, Stockholm, Sweden; CIBERESP (CIBER of Epidemiology and Public Health) Instituto de Salud Carlos III, Madrid, Spain.IIS Aragón, Hospital Universitario Miguel Servet, Universidad de Zaragoza, Spain; CIBERCV Instituto de Salud Carlos III, Madrid, Spain.IIS Aragón, Hospital Universitario Miguel Servet, Universidad de Zaragoza, Spain; CIBERCV Instituto de Salud Carlos III, Madrid, Spain; Agencia Aragonesa para la Investigación y el Desarrollo (ARAID), Zaragoza, Spain.Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid, CEI UAM+CSIC, Madrid, Spain.IIS Aragón, Hospital Universitario Miguel Servet, Universidad de Zaragoza, Spain; CIBERCV Instituto de Salud Carlos III, Madrid, Spain.Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid, CEI UAM+CSIC, Madrid, Spain; CIBERESP (CIBER of Epidemiology and Public Health) Instituto de Salud Carlos III, Madrid, Spain; Instituto de Investigación IdiPaz, Madrid, Spain; IMDEA-Food Institute, Madrid, Spain. Electronic address: mpilar.guallar@uam.es.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31918334

Citation

Donat-Vargas, Carolina, et al. "Exposure to Dietary Polychlorinated Biphenyls and Dioxins, and Its Relationship With Subclinical Coronary Atherosclerosis: the Aragon Workers' Health Study." Environment International, vol. 136, 2020, p. 105433.
Donat-Vargas C, Moreno-Franco B, Laclaustra M, et al. Exposure to dietary polychlorinated biphenyls and dioxins, and its relationship with subclinical coronary atherosclerosis: The Aragon Workers' Health Study. Environ Int. 2020;136:105433.
Donat-Vargas, C., Moreno-Franco, B., Laclaustra, M., Sandoval-Insausti, H., Jarauta, E., & Guallar-Castillon, P. (2020). Exposure to dietary polychlorinated biphenyls and dioxins, and its relationship with subclinical coronary atherosclerosis: The Aragon Workers' Health Study. Environment International, 136, 105433. https://doi.org/10.1016/j.envint.2019.105433
Donat-Vargas C, et al. Exposure to Dietary Polychlorinated Biphenyls and Dioxins, and Its Relationship With Subclinical Coronary Atherosclerosis: the Aragon Workers' Health Study. Environ Int. 2020;136:105433. PubMed PMID: 31918334.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exposure to dietary polychlorinated biphenyls and dioxins, and its relationship with subclinical coronary atherosclerosis: The Aragon Workers' Health Study. AU - Donat-Vargas,Carolina, AU - Moreno-Franco,Belén, AU - Laclaustra,Martín, AU - Sandoval-Insausti,Helena, AU - Jarauta,Estibaliz, AU - Guallar-Castillon,Pilar, Y1 - 2020/01/06/ PY - 2019/10/02/received PY - 2019/12/17/revised PY - 2019/12/18/accepted PY - 2020/1/10/pubmed PY - 2020/9/12/medline PY - 2020/1/10/entrez KW - Dietary polychlorinated biphenyls (PCBs) KW - Nutritional and environmental epidemiology KW - Subclinical coronary atherosclerosis SP - 105433 EP - 105433 JF - Environment international JO - Environ Int VL - 136 N2 - BACKGROUND: Experimental evidence has revealed that exposure to polychlorinated biphenyls (PCBs) and dioxins directly impairs endothelial function and induces atherosclerosis progression. In the general population, despite a small number of recent studies finding a link between PCBs, and stroke and myocardial infraction, the association with early coronary atherosclerosis has not been examined yet. OBJECTIVE: To examine whether dietary exposure to PCBs and dioxins is associated with subclinical coronary atherosclerosis in a middle-aged men. DESIGN: Cross-sectional analysis comprising 1844 men in their 50 s and free of cardiovascular disease, who participated in the Aragon Workers' Health Study (AWHS). Individual dietary exposures to PCBs and dioxins were estimated by the contaminant's concentration in food coupled with the corresponding consumption and then participants were classified into quartiles of consumption. Coronary artery calcium score (CACS) was assessed by computerized tomography. We conducted ordered logistic regressions to estimate the odds ratio (OR) and 95% confidence intervals (CIs) for progression to the categories of more coronary artery calcium, adjusting for potential confounders. RESULTS: Among the participants, coronary calcium was not shown in 60.1% (n = 1108), 29.8% had a CACS > 0 and <100 (n = 550), and the remaining 10.1% (n = 186) had a CACS ≥ 100. Compared with those in the first quartile of PCBs exposure, those in the fourth one had an increased odds for having coronary calcium (OR 2.02, 95% CI [1.18, 3.47], p trend 0.019) and for having progressed to categories of more intense calcification (OR 2.03, 95% CI [1.21, 3.40], p trend 0.012). However, no association was found between dietary dioxins exposure and prevalent coronary artery calcium. CONCLUSIONS: In this general male population, dietary exposure to PCBs, but not to dioxins, was associated with a higher prevalence of coronary calcium and to more intense subclinical coronary atherosclerosis. PCBs exposure seems to increase the risk of coronary disease in men from the very early stages. SN - 1873-6750 UR - https://www.unboundmedicine.com/medline/citation/31918334/full_citation L2 - https://linkinghub.elsevier.com/retrieve/pii/S0160-4120(19)33660-8 DB - PRIME DP - Unbound Medicine ER -