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The epidemiology of headaches among patients with epilepsy: a systematic review and meta-analysis.
J Headache Pain 2020; 21(1):3JH

Abstract

BACKGROUND

Headache is the symptom of pain in the face, head or neck that causes disability in most people with medical and neurological disorders. It frequently co-occurs with most chronic diseases such as epilepsy and significantly impacts the quality of life. However, epidemiologic data from different studies showed different rates of prevalence. Therefore, we conducted this review to summarize the available epidemiologic evidence on the topic and formulate recommendations for future research and clinical practice.

METHODS

We followed the preferred reporting items for systematic review and meta-analysis (PRISMA) guidelines. We systematically searched the literature using popular databases such as PubMed, EMBASE, Psych-INFO, and SCOPUS. We further scanned the reference lists of the eligible studies to supplement our electronic search. The Comprehensive Meta-Analysis software version 3.0 (CMA 3.0) was used to conduct a meta-analysis. Subgroup and sensitivity analysis were performed and Cochran's Q- and the I2- test were used to assess the source of heterogeneity. The funnel plot and Egger's regression tests were used to assess potential publication bias.

RESULTS

A total of 17 studies conducted both in developed and developing countries including 5564 study participants were combined in this meta-analysis. The pooled estimated prevalence of headache among patients with epilepsy was 48.4%. The pooled estimated prevalence of Inter-Ictal headache (IIH) (42.2%) and Postictal headache (PIH) (43.1%) were higher when compared to tension-type headache (TTH) (26.2%), migraine with aura (26.0%) and migraine without aura (10.4%). The pooled prevalence of headache was 50.6% and 49.5% for developed and developing countries respectively. The pooled prevalence of headache among patients with epilepsy was considerably higher among females (63.0%) when compared to males (33.3%). Moreover, the pooled estimated prevalence of headache among patients with epilepsy was ranging from 46.0% to 52.2% in a leave-one-out sensitivity analysis.

CONCLUSION

The pooled estimated prevalence of headache among patients with epilepsy was considerably high (48.4%). Screening and appropriate management of headaches among patients with epilepsy are warranted.

Authors+Show Affiliations

College of Medicine and Health Sciences, Hawassa University, Hawassa, Ethiopia. berkole.dad@gmail.com.College of Medicine and Health Sciences, Hawassa University, Hawassa, Ethiopia.College of Medicine and Health Sciences, Hawassa University, Hawassa, Ethiopia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31924166

Citation

Duko, Bereket, et al. "The Epidemiology of Headaches Among Patients With Epilepsy: a Systematic Review and Meta-analysis." The Journal of Headache and Pain, vol. 21, no. 1, 2020, p. 3.
Duko B, Ayalew M, Toma A. The epidemiology of headaches among patients with epilepsy: a systematic review and meta-analysis. J Headache Pain. 2020;21(1):3.
Duko, B., Ayalew, M., & Toma, A. (2020). The epidemiology of headaches among patients with epilepsy: a systematic review and meta-analysis. The Journal of Headache and Pain, 21(1), p. 3. doi:10.1186/s10194-020-1074-0.
Duko B, Ayalew M, Toma A. The Epidemiology of Headaches Among Patients With Epilepsy: a Systematic Review and Meta-analysis. J Headache Pain. 2020 Jan 10;21(1):3. PubMed PMID: 31924166.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The epidemiology of headaches among patients with epilepsy: a systematic review and meta-analysis. AU - Duko,Bereket, AU - Ayalew,Mohammed, AU - Toma,Alemayehu, Y1 - 2020/01/10/ PY - 2019/12/09/received PY - 2020/01/05/accepted PY - 2020/1/12/entrez PY - 2020/1/12/pubmed PY - 2020/1/12/medline KW - Epilepsy KW - Headaches KW - Meta-analysis KW - Prevalence KW - Seizure KW - Systematic review SP - 3 EP - 3 JF - The journal of headache and pain JO - J Headache Pain VL - 21 IS - 1 N2 - BACKGROUND: Headache is the symptom of pain in the face, head or neck that causes disability in most people with medical and neurological disorders. It frequently co-occurs with most chronic diseases such as epilepsy and significantly impacts the quality of life. However, epidemiologic data from different studies showed different rates of prevalence. Therefore, we conducted this review to summarize the available epidemiologic evidence on the topic and formulate recommendations for future research and clinical practice. METHODS: We followed the preferred reporting items for systematic review and meta-analysis (PRISMA) guidelines. We systematically searched the literature using popular databases such as PubMed, EMBASE, Psych-INFO, and SCOPUS. We further scanned the reference lists of the eligible studies to supplement our electronic search. The Comprehensive Meta-Analysis software version 3.0 (CMA 3.0) was used to conduct a meta-analysis. Subgroup and sensitivity analysis were performed and Cochran's Q- and the I2- test were used to assess the source of heterogeneity. The funnel plot and Egger's regression tests were used to assess potential publication bias. RESULTS: A total of 17 studies conducted both in developed and developing countries including 5564 study participants were combined in this meta-analysis. The pooled estimated prevalence of headache among patients with epilepsy was 48.4%. The pooled estimated prevalence of Inter-Ictal headache (IIH) (42.2%) and Postictal headache (PIH) (43.1%) were higher when compared to tension-type headache (TTH) (26.2%), migraine with aura (26.0%) and migraine without aura (10.4%). The pooled prevalence of headache was 50.6% and 49.5% for developed and developing countries respectively. The pooled prevalence of headache among patients with epilepsy was considerably higher among females (63.0%) when compared to males (33.3%). Moreover, the pooled estimated prevalence of headache among patients with epilepsy was ranging from 46.0% to 52.2% in a leave-one-out sensitivity analysis. CONCLUSION: The pooled estimated prevalence of headache among patients with epilepsy was considerably high (48.4%). Screening and appropriate management of headaches among patients with epilepsy are warranted. SN - 1129-2377 UR - https://www.unboundmedicine.com/medline/citation/31924166/The_epidemiology_of_headaches_among_patients_with_epilepsy L2 - https://thejournalofheadacheandpain.biomedcentral.com/articles/10.1186/s10194-020-1074-0 DB - PRIME DP - Unbound Medicine ER -