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Fifteen new diterpenoid alkaloids from the roots of Aconitum kirinense Nakai.
Fitoterapia. 2020 Mar; 141:104477.F

Abstract

Extensive phytochemical investigation from the roots of Aconitum kirinense Nakai led to the identification of fifteen new compounds, including four ranaconitine type C18-diterpenoid alkaloids (kirisines A-D, 1-4), one lappaconitine type C18-diterpenoid alkaloid (kirisine E, 5), seven denudatine type C20-diterpenoid alkaloids (kirisines F-L, 6-12), and three napelline type C20-diterpenoid alkaloids (kirisines M-O, 13-15), together with 25 known ones. Their structures were elucidated by extensive spectroscopic analyses. Among them, compounds 1 and 2 are rare diterpenoid alkaloid with 9,14-methylenedioxy group, and the latter also has a rare chloro-substituent. The diterpenoid alkaloids isolated were C18, C19 and C20-category, which might provide further clues for understanding the chemotaxonomic significance of this plant. The isolated compounds were tested for neuroprotective activity and acetylcholinesterase inhibitory activity. Compounds 7, 18, 30 and 40 which exhibited moderate activity at 80 μM against acetylcholinesterase.

Authors+Show Affiliations

Laboratory of Chemistry and Biodiversity, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China.Laboratory of Chemistry and Biodiversity, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China.Laboratory of Chemistry and Biodiversity, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China.Laboratory of Chemistry and Biodiversity, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China.Laboratory of Chemistry and Biodiversity, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China. Electronic address: zhouxl@swjtu.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31927015

Citation

Jiang, Guang-You, et al. "Fifteen New Diterpenoid Alkaloids From the Roots of Aconitum Kirinense Nakai." Fitoterapia, vol. 141, 2020, p. 104477.
Jiang GY, Qin LL, Gao F, et al. Fifteen new diterpenoid alkaloids from the roots of Aconitum kirinense Nakai. Fitoterapia. 2020;141:104477.
Jiang, G. Y., Qin, L. L., Gao, F., Huang, S., & Zhou, X. L. (2020). Fifteen new diterpenoid alkaloids from the roots of Aconitum kirinense Nakai. Fitoterapia, 141, 104477. https://doi.org/10.1016/j.fitote.2020.104477
Jiang GY, et al. Fifteen New Diterpenoid Alkaloids From the Roots of Aconitum Kirinense Nakai. Fitoterapia. 2020;141:104477. PubMed PMID: 31927015.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fifteen new diterpenoid alkaloids from the roots of Aconitum kirinense Nakai. AU - Jiang,Guang-You, AU - Qin,Li-Li, AU - Gao,Feng, AU - Huang,Shuai, AU - Zhou,Xian-Li, Y1 - 2020/01/10/ PY - 2019/12/06/received PY - 2020/01/08/revised PY - 2020/01/08/accepted PY - 2020/1/14/pubmed PY - 2020/11/18/medline PY - 2020/1/14/entrez KW - 9,14-methylenedioxy KW - Acetylcholinesterase KW - Aconitum kirinense Nakai KW - Chloro-substituent KW - Diterpenoid alkaloids KW - Ranunculaceae SP - 104477 EP - 104477 JF - Fitoterapia JO - Fitoterapia VL - 141 N2 - Extensive phytochemical investigation from the roots of Aconitum kirinense Nakai led to the identification of fifteen new compounds, including four ranaconitine type C18-diterpenoid alkaloids (kirisines A-D, 1-4), one lappaconitine type C18-diterpenoid alkaloid (kirisine E, 5), seven denudatine type C20-diterpenoid alkaloids (kirisines F-L, 6-12), and three napelline type C20-diterpenoid alkaloids (kirisines M-O, 13-15), together with 25 known ones. Their structures were elucidated by extensive spectroscopic analyses. Among them, compounds 1 and 2 are rare diterpenoid alkaloid with 9,14-methylenedioxy group, and the latter also has a rare chloro-substituent. The diterpenoid alkaloids isolated were C18, C19 and C20-category, which might provide further clues for understanding the chemotaxonomic significance of this plant. The isolated compounds were tested for neuroprotective activity and acetylcholinesterase inhibitory activity. Compounds 7, 18, 30 and 40 which exhibited moderate activity at 80 μM against acetylcholinesterase. SN - 1873-6971 UR - https://www.unboundmedicine.com/medline/citation/31927015/Fifteen_new_diterpenoid_alkaloids_from_the_roots_of_Aconitum_kirinense_Nakai_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0367-326X(19)32387-1 DB - PRIME DP - Unbound Medicine ER -